Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.452 | 0.1027 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0203 | 0.5672 | 0.5264 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0203 | 0.5672 | 0.5264 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.7624 | 0.7574 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0311 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0203 | 0.5672 | 0.5264 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.679 |
Echinococcus granulosus | beta galactosidase | 0.016 | 0.3963 | 0.3394 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.3963 | 0.3836 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.016 | 0.3963 | 0.3394 |
Schistosoma mansoni | alpha-glucosidase | 0.0311 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0311 | 1 | 1 |
Onchocerca volvulus | 0.0311 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.854 | 0.8509 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0061 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.452 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.7624 | 0.2443 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0861 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0232 | 0.6856 | 0.4612 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0203 | 0.5672 | 0.5264 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0105 | 0.1776 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0311 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0203 | 0.5672 | 0.5264 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3037 | 0.289 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0203 | 0.5672 | 0.5264 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0861 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0311 | 1 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0861 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0311 | 1 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.016 | 0.3963 | 0.3394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibitory concentration of the compound against Xanthine oxidase; Not active at 50 ug/mL concentration | ChEMBL. | 12873513 |
IC50 (binding) | NA 0 uM | Inhibitory concentration of the compound against Xanthine oxidase; Not active at 50 ug/mL concentration | ChEMBL. | 12873513 |
IC50 (binding) | = 77.76 uM | Inhibition of yeast Alpha-glucosidase | ChEMBL. | 12873513 |
SC50 (binding) | = 11.53 uM | Free radical scavenging assessed as DPPH colour reduction | ChEMBL. | 12873513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.