Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.4851 | 1 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0149 | 1 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0097 | 0.4851 | 0.2902 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0149 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0097 | 0.4851 | 0.2902 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0097 | 0.4851 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.4851 | 0.2902 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2746 | 0.5661 |
Echinococcus granulosus | death domain containing protein | 0.0097 | 0.4851 | 0.2902 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2746 | 0.5661 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0097 | 0.4851 | 0.2902 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.4851 | 1 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0097 | 0.4851 | 0.2902 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0097 | 0.4851 | 0.2902 |
Echinococcus multilocularis | Ankyrin | 0.0097 | 0.4851 | 0.2902 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.4851 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2746 | 0.5661 |
Brugia malayi | Uncoordinated protein 44 | 0.0097 | 0.4851 | 1 |
Brugia malayi | Death domain containing protein | 0.0097 | 0.4851 | 1 |
Onchocerca volvulus | Netrin receptor homolog | 0.0097 | 0.4851 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2746 | 0.5661 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0097 | 0.4851 | 1 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0149 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2746 | 0.5661 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0097 | 0.4851 | 0.2902 |
Schistosoma mansoni | netrin receptor unc5 | 0.0097 | 0.4851 | 0.2902 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2746 | 0.5661 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0149 | 1 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0097 | 0.4851 | 0.2902 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.