Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0179 | 0.5437 | 0.5437 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.5437 | 0.5437 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4223 | 1 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.031 | 1 | 1 |
Trypanosoma brucei | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Plasmodium falciparum | guanylate kinase | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | discs large, putative | 0.0023 | 0 | 0.5 |
Plasmodium vivax | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4223 | 1 |
Mycobacterium leprae | Probable guanylate kinase Gmk (GMP kinase). | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable guanylate kinase Gmk | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4223 | 1 |
Trichomonas vaginalis | sap-102, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0179 | 0.5437 | 0.5437 |
Giardia lamblia | Guanylate kinase | 0.0023 | 0 | 0.5 |
Leishmania major | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | guanylate kinase | 0.0023 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | guanylate kinase | 0.0023 | 0 | 0.5 |
Chlamydia trachomatis | guanylate kinase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 1 | 0.031 | 1 | 1 |
Trypanosoma brucei | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Leishmania major | guanylate kinase-like protein | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | guanylate kinase family protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.5437 | 0.5437 |
Trypanosoma cruzi | guanylate kinase, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.