TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.447 | Formula: C26H27FNNa2O6P
H donors: 1 H acceptors: 6 LogP: 3.72 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: O[C@@H](CP(=O)(OCc1c(nc(c(c1c1ccc(cc1)F)C)c1ccccc1)C(C)C)[O-])CC(=O)[O-].[Na+].[Na+]
InChi: 1S/C26H29FNO6P.2Na/c1-16(2)25-22(14-34-35(32,33)15-21(29)13-23(30)31)24(18-9-11-20(27)12-10-18)17(3)26(28-25)19-7-5-4-6-8-19;;/h4-12,16,21,29H,13-15H2,1-3H3,(H,30,31)(H,32,33);;/q;2*+1/p-2/t21-;;/m1../s1
InChiKey: HGJBFCALPNDBIW-GHVWMZMZSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	HMG-CoA reductase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	Get druggable targets OG5_127955	All targets in OG5_127955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania donovani	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma congolense	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Candida albicans	hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)	Get druggable targets OG5_127955	All targets in OG5_127955
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania braziliensis	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Candida albicans	hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania infantum	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma brucei gambiense	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Schistosoma japonicum	ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania mexicana	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	carboxylesterase	0.0081	0.0361	0.0361
Onchocerca volvulus		0.0042	0.0149	0.3339
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0097	0.0097
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0044	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0044	0.0158	0.012
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0009	0.0009
Entamoeba histolytica	protein kinase, putative	0.0186	0.0943	0.1455
Brugia malayi	nuclear receptor RXR	0.0017	0.001	0.001
Echinococcus granulosus	carbonic anhydrase	0.086	0.4684	0.4684
Brugia malayi	Carboxylesterase family protein	0.0081	0.0361	0.0361
Schistosoma mansoni	carbonic anhydrase-related	0.086	0.4684	0.4684
Mycobacterium ulcerans	carbonic anhydrase	0.1512	0.8293	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.001	0.001
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Brugia malayi	Matrixin family protein	0.0042	0.0149	0.0149
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0044	0.0158	0.0158
Trichomonas vaginalis	conserved hypothetical protein	0.1512	0.8293	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0186	0.0943	0.089
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0097	0.0097
Echinococcus granulosus	carboxylesterase 5A	0.0081	0.0361	0.0361
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0017	0.001	0.001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0159	0.0159
Echinococcus multilocularis	protein dispatched 1	0.0068	0.0291	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.1512	0.8293	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0044	0.0158	0.01
Echinococcus multilocularis	carbonic anhydrase	0.086	0.4684	0.4684
Echinococcus granulosus	acetylcholinesterase	0.0081	0.0361	0.0361
Echinococcus multilocularis	ubiquitin specific protease 41	0.0044	0.0158	0.0158
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0097	0.0097
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0068	0.0291	0.0291
Trypanosoma brucei	carbonic anhydrase-like protein	0.1819	1	1
Schistosoma mansoni	kinase	0.0049	0.0187	0.0187
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0097	0.0097
Echinococcus granulosus	acetylcholinesterase	0.0081	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.086	0.4684	0.4684
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0291	0.0282
Brugia malayi	hypothetical protein	0.0017	0.001	0.001
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0254	0.0254
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0159	0.0159
Brugia malayi	Matrixin family protein	0.0042	0.0149	0.0149
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0165	0.0829	0.0775
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0254	0.0254
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0159	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0097	0.0097
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Echinococcus granulosus	lamin	0.0032	0.0092	0.0092
Giardia lamblia	Kinase, PLK	0.0096	0.0446	1
Brugia malayi	RNA binding protein	0.0061	0.0254	0.0254
Brugia malayi	Matrixin family protein	0.0103	0.0483	0.0483
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0033	0.0097	0.2176
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0097	0.0097
Brugia malayi	Hemopexin family protein	0.006	0.0247	0.0247
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0352	0.1867	0.2715
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0097	0.0097
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0097	0.0097
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0186	0.0943	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0159	0.0159
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0165	0.0829	0.0775
Echinococcus multilocularis	dual specificity	0.0186	0.0943	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0361	0.0361
Echinococcus multilocularis	acetylcholinesterase	0.0081	0.0361	0.0361
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.086	0.4684	0.4684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0159	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0097	0.0097
Echinococcus multilocularis	lamin	0.0032	0.0092	0.0092
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0044	0.0158	0.0158
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0044	0.0158	0.01
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0254	0.0254
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0097	0.0097
Loa Loa (eye worm)	acetylcholinesterase 1	0.0081	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0165	0.0829	0.0829
Brugia malayi	Carboxylesterase family protein	0.0081	0.0361	0.0361
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0097	0.0097
Echinococcus multilocularis	acetylcholinesterase	0.0081	0.0361	0.0361
Loa Loa (eye worm)	matrixin family protein	0.0103	0.0483	0.0483
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0771	0.4187	0.6494
Brugia malayi	hypothetical protein	0.0017	0.001	0.001
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0042	0.0149	0.0149
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.001	0.001
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0165	0.0829	0.0775
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0097	0.0097
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0165	0.0829	0.0829
Brugia malayi	ecdysteroid receptor	0.0033	0.0097	0.0097
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0154	0.0769	0.0769
Echinococcus granulosus	ubiquitin specific protease 41	0.0044	0.0158	0.0158
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.0343	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0291	0.0291
Brugia malayi	steroid hormone receptor	0.0033	0.0097	0.0097
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0097	0.0097
Brugia malayi	Flap endonuclease-1	0.0026	0.0059	0.0059
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0078	0.0343	0.7351
Echinococcus multilocularis	protein patched	0.0068	0.0291	0.0291
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0068	0.0291	0.0291
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.018	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0158	0.0158
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0059	0.0059
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0059	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0183	0.0929	0.0929
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0097	0.0097
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0097	0.0097
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.086	0.4684	0.4684
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0165	0.0829	0.0829
Schistosoma mansoni	hypothetical protein	0.0372	0.1978	0.1978
Schistosoma mansoni	coup transcription factor	0.0033	0.0097	0.0097
Echinococcus granulosus	carbonic anhydrase II	0.1819	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.018	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0088	0.0088
Onchocerca volvulus	Protein ultraspiracle homolog	0.0033	0.0097	0.2176
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.086	0.4684	0.4684
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.1123	0.6141	1
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0092	0.0092
Schistosoma mansoni	patched 1	0.0068	0.0291	0.0291
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0186	0.0943	0.089
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0097	0.0097
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0254	0.0254
Echinococcus multilocularis	carbonic anhydrase II	0.1819	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0097	0.0097
Entamoeba histolytica	carbonic anhydrase, putative	0.1123	0.6141	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0159	0.0159
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0044	0.0158	0.012
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0097	0.0097
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0186	0.0943	0.089
Echinococcus multilocularis	carbonic anhydrase	0.086	0.4684	0.4684
Brugia malayi	Matrixin family protein	0.0042	0.0149	0.0149
Trypanosoma brucei	polo-like protein kinase	0.0096	0.0446	0.0389
Echinococcus granulosus	lamin dm0	0.0032	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0097	0.0097
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0044	0.0158	0.0158
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.001	0.001
Echinococcus multilocularis	carboxylesterase 5A	0.0081	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0052	0.02	0.02
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.0343	0.0345
Echinococcus multilocularis	lamin dm0	0.0032	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0092	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0097	0.0097
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0936	0.0936
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0446	0.0446
Entamoeba histolytica	hypothetical protein	0.0186	0.0943	0.1455
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.0446	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0044	0.0158	0.0158
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.0446	0.0446
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0097	0.0097
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0254	0.0254
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0097	0.0097
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0159	0.0159
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0097	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0097	0.0097
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0165	0.0829	0.0775
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0254	0.0254
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0097	0.0097
Echinococcus granulosus	sterol regulatory element binding protein	0.0068	0.0291	0.0291
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.015	0.0745	0.0745
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.0446	0.0446
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0097	0.0097
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.0446	0.0389
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.0446	0.0389
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0097	0.0097
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0097	0.0097
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0094	0.0436	0.9772
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.001	0.001
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.0343	0.0345
Onchocerca volvulus		0.006	0.0247	0.5546
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0254	0.0254
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.0446	0.0446
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0186	0.0943	0.089
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0097	0.0097
Echinococcus granulosus	carbonic anhydrase	0.086	0.4684	0.4684
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0154	0.0769	0.0769
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0097	0.0097
Schistosoma mansoni	hypothetical protein	0.086	0.4684	0.4684
Loa Loa (eye worm)	hypothetical protein	0.0017	0.001	0.001
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.015	0.0745	0.0745
Onchocerca volvulus	Matrilysin homolog	0.0094	0.0436	0.9772
Schistosoma mansoni	hypothetical protein	0.006	0.0247	0.0247
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0097	0.0097
Mycobacterium ulcerans	carbonic anhydrase	0.1123	0.6141	0.734
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.1819	1	1
Onchocerca volvulus		0.0033	0.0097	0.2176
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0097	0.0097
Onchocerca volvulus	Bile acid receptor homolog	0.0033	0.0097	0.2176
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0044	0.0158	0.0158
Entamoeba histolytica	protein kinase domain containing protein	0.0186	0.0943	0.1455
Loa Loa (eye worm)	hypothetical protein	0.086	0.4684	0.4684
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0361	0.0361
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0254	0.0254
Onchocerca volvulus		0.0032	0.0092	0.2054
Brugia malayi	Protein kinase domain containing protein	0.0186	0.0943	0.0943
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0165	0.0829	0.0829
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0097	0.0097
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0254	0.0254
Brugia malayi	intermediate filament protein	0.0032	0.0092	0.0092
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.1159	0.634	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0068	0.0291	0.0291
Loa Loa (eye worm)	matrix metalloproteinase	0.0042	0.0149	0.0149
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.0446	0.0389
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.086	0.4684	0.4684
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0829	0.0829
Echinococcus multilocularis	sterol regulatory element binding protein	0.0068	0.0291	0.0291
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0097	0.0097
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0254	0.0254
Onchocerca volvulus	Matrilysin homolog	0.0042	0.0149	0.3339
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0097	0.0097
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0044	0.0158	0.01
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.086	0.4684	0.4684
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0149	0.0149
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Loa Loa (eye worm)	matrixin family protein	0.0094	0.0436	0.0436
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0059	0.0059
Toxoplasma gondii	hypothetical protein	0.086	0.4684	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0097	0.0097
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0045	0.0045
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.1819	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0097	0.0097
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0097	0.0097
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0254	0.0254
Echinococcus granulosus	Niemann Pick C1 protein	0.0068	0.0291	0.0291
Schistosoma mansoni	thyroid hormone receptor	0.0183	0.0929	0.0929
Echinococcus granulosus	dual specificity	0.0186	0.0943	0.0943
Entamoeba histolytica	protein kinase, putative	0.0186	0.0943	0.1455
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0183	0.0929	0.0929
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0052	0.02	0.02
Leishmania major	carbonic anhydrase family protein, putative	0.1123	0.6141	0.6118
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0097	0.0097
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0044	0.0158	0.0158
Echinococcus granulosus	geminin	0.0372	0.1978	0.1978
Echinococcus granulosus	intermediate filament protein	0.0032	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0186	0.0943	0.0943
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0092	0.0092
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0165	0.0829	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0017	0.001	0.001
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.086	0.4684	0.4684
Schistosoma mansoni	carbonic anhydrase	0.086	0.4684	0.4684
Brugia malayi	TAR-binding protein	0.0061	0.0254	0.0254
Plasmodium falciparum	carbonic anhydrase	0.086	0.4684	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0097	0.0097
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0044	0.0158	0.2558
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Schistosoma mansoni	hypothetical protein	0.015	0.0745	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0097	0.0097
Schistosoma mansoni	carbonic anhydrase-related	0.086	0.4684	0.4684
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0044	0.0158	0.01
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0097	0.0097
Brugia malayi	nuclear hormone receptor	0.0033	0.0097	0.0097
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0097	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0097	0.0097
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0097	0.0097
Brugia malayi	Matrixin family protein	0.0042	0.0149	0.0149
Echinococcus multilocularis	musashi	0.0032	0.0092	0.0092
Schistosoma mansoni	lamin	0.0032	0.0092	0.0092
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0059	0.0059
Echinococcus granulosus	Protein patched homolog 1	0.0068	0.0291	0.0291
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0159	0.0159
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0081	0.0361	0.0361
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0097	0.0097
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0017	0.001	0.001
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.1819	1	1
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.1819	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0097	0.0097
Loa Loa (eye worm)	carbonic anhydrase 3	0.1819	1	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0936	0.0936
Schistosoma mansoni	lamin	0.0032	0.0092	0.0092
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0097	0.0097
Onchocerca volvulus		0.0032	0.0092	0.2054
Brugia malayi	CHE-14 protein	0.0068	0.0291	0.0291
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0017	0.001	0.001
Leishmania major	carbonic anhydrase-like protein	0.1819	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0446	0.047
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0097	0.0097
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0097	0.0097
Schistosoma mansoni	carbonic anhydrase	0.1123	0.6141	0.6141
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0158	0.012
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.1819	1	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.086	0.4684	0.4684
Echinococcus multilocularis	geminin	0.0372	0.1978	0.1978
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.0446	0.0636
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0097	0.0097
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0044	0.0158	0.0163
Echinococcus granulosus	carbonic anhydrase	0.086	0.4684	0.4684
Schistosoma mansoni	carbonic anhydrase-related	0.086	0.4684	0.4684
Echinococcus multilocularis	carbonic anhydrase	0.086	0.4684	0.4684
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.1819	1	1
Schistosoma mansoni	hypothetical protein	0.0372	0.1978	0.1978

Activities

Activity type	Activity value	Assay description	Source	Reference
I50 (functional)	= 5.1 nM	The compound was tested in vitro for inhibition of rat hepatic HMG-CoA reductase.	ChEMBL.	1895299
IC50 (functional)	= 5.1 nM	The compound was tested in vitro for inhibition of rat hepatic HMG-CoA reductase.	ChEMBL.	1895299

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 157619