Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0122 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0122 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0463 | 0.7358 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0122 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0463 | 0.7358 | 0.7358 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0122 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0122 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0463 | 0.7358 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0585 | 1 | 1 |
Onchocerca volvulus | 0.0585 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0122 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0463 | 0.7358 | 1 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0122 | 0 | 0.5 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0122 | 0 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0122 | 0 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0122 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0585 | 1 | 1 |
Onchocerca volvulus | 0.0585 | 1 | 1 | |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0122 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0122 | 0 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0122 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0122 | 0 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0122 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0463 | 0.7358 | 0.7358 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0463 | 0.7358 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0122 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0585 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0122 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 uM | In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determined | ChEMBL. | 10956194 |
IC50 (binding) | = 4 uM | In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determined | ChEMBL. | 10956194 |
IC50 (binding) | > 66 uM | In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]-AA (50 uM) was determined | ChEMBL. | 10956194 |
IC50 (binding) | > 66 uM | In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]-AA (50 uM) was determined | ChEMBL. | 10956194 |
Selectivity (binding) | > 17 | Selectivity ratio of IC50s from COX-1 and COX-2 | ChEMBL. | 10956194 |
Selectivity (binding) | > 17 | Selectivity ratio of IC50s from COX-1 and COX-2 | ChEMBL. | 10956194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.