Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.079 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.079 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.079 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0041 | 0.079 | 0.079 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.026 | 1 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0041 | 0.079 | 0.079 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.079 | 0.5 |
Brugia malayi | nicalin | 0.0041 | 0.079 | 0.079 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.026 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0041 | 0.079 | 0.079 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0041 | 0.079 | 0.079 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0041 | 0.079 | 0.079 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0041 | 0.079 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0041 | 0.079 | 0.079 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0041 | 0.079 | 0.079 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0041 | 0.079 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0041 | 0.079 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.079 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0041 | 0.079 | 0.079 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.079 | 0.079 |
Onchocerca volvulus | 0.0041 | 0.079 | 0.079 | |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.079 | 0.079 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.079 | 0.079 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.026 | 1 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0041 | 0.079 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0041 | 0.079 | 0.079 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0.079 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0041 | 0.079 | 0.079 |
Leishmania major | glutaminyl cyclase, putative | 0.0041 | 0.079 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0041 | 0.079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.079 | 0.079 |
Brugia malayi | leucyl aminopeptidase | 0.0041 | 0.079 | 0.079 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0041 | 0.079 | 0.079 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0041 | 0.079 | 0.079 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0041 | 0.079 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.079 | 0.5 |
Brugia malayi | FXNA | 0.0041 | 0.079 | 0.079 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0041 | 0.079 | 0.079 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0041 | 0.079 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 30 uM | Partial agonist activity at human nAChR alpha4beta2 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay | ChEMBL. | 21962147 |
Emax (functional) | = 9 % | Partial agonist activity at human nAChR alpha4beta2 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay relative to nicotine | ChEMBL. | 21962147 |
Ki (binding) | = 8.96 | Displacement of [3H]cytisine from nAChR alpha4beta2 in rat brain membrane | ChEMBL. | 21962147 |
Ki (binding) | = 1.1 nM | Displacement of [3H]cytisine from nAChR alpha4beta2 in rat brain membrane | ChEMBL. | 21962147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.