Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe | 0.013 | 0.0392 | 0.0355 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0085 | 0.2156 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0009 | 0.0238 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0009 | 0.0088 |
Entamoeba histolytica | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0038 | 0.0359 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0009 | 0.0088 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0009 | 0.0088 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0061 | 0.0201 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0144 | 0.1357 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.0394 | 1 |
Trypanosoma cruzi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0009 | 0.0088 |
Echinococcus multilocularis | UDP N acetylglucosamine dolichyl phosphate | 0.013 | 0.0392 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0038 | 0.0359 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0147 | 0.3087 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.118 | 0.3783 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0144 | 0.1357 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0061 | 0.0023 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0009 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0038 | 0.0359 |
Brugia malayi | RNA, U transporter 1 | 0.009 | 0.0262 | 0.6639 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0061 | 0.0023 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0144 | 0.1357 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.0147 | 0.3087 |
Echinococcus granulosus | UDP N acetylglucosamine dolichyl phosphate | 0.013 | 0.0392 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0038 | 0.0359 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.3103 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0061 | 0.0201 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.118 | 0.3783 | 1 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.3103 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.1062 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0009 | 0.0088 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0009 | 0.0088 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0337 | 0.1062 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0009 | 0.0088 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.013 | 0.0392 | 0.995 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0009 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0061 | 0.0573 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0061 | 0.0023 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0009 | 0.0238 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0009 | 0.0238 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0147 | 0.1389 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0009 | 0.0088 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.005 | 0.0473 |
Trypanosoma cruzi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0009 | 0.0238 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0144 | 0.1357 |
Onchocerca volvulus | 0.0028 | 0.0061 | 0.1343 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0061 | 0.0573 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0009 | 0.0088 |
Leishmania major | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0144 | 0.1357 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0061 | 0.0201 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0144 | 0.1357 |
Trypanosoma brucei | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.3103 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0009 | 0.0088 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0073 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Plasmodium falciparum | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0144 | 0.1357 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0392 | 0.3694 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0061 | 0.0023 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0147 | 0.2762 |
Echinococcus granulosus | snurportin 1 | 0.0337 | 0.1062 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0009 | 0.0238 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0009 | 0.0088 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0061 | 0.0201 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0009 | 0.0238 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0073 | 0.0691 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0061 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0061 | 0.0573 |
Echinococcus multilocularis | snurportin 1 | 0.0337 | 0.1062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Giardia lamblia | UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase | 0.013 | 0.0392 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0073 | 0.0691 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0009 | 0.0088 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.005 | 0.0473 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.0147 | 0.2324 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.0144 | 0.3656 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0073 | 0.0691 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0061 | 0.0201 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0147 | 0.374 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0061 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0009 | 0.0088 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0061 | 0.0023 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0009 | 0.0088 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.0147 | 0.2324 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0009 | 0.0238 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0009 | 0.0088 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0061 | 0.0023 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0009 | 0.0088 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0061 | 0.0023 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0073 | 0.0691 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0061 | 0.1543 |
Onchocerca volvulus | 0.013 | 0.0392 | 1 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0009 | 0.0238 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0144 | 0.1357 |
Schistosoma mansoni | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.013 | 0.0392 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0147 | 0.2762 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0009 | 0.0238 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0009 | 0.0238 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0009 | 0.0088 |
Schistosoma mansoni | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.013 | 0.0392 | 0.3694 |
Toxoplasma gondii | glycosyl transferase, group 4 family protein | 0.013 | 0.0392 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.0394 | 0.3712 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0009 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0038 | 0.0359 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0061 | 0.1543 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0061 | 0.0026 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0009 | 0.0238 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0061 | 0.1543 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0073 | 0.1861 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0009 | 0.0238 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0009 | 0.0238 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0009 | 0.0088 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0009 | 0.0088 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0009 | 0.0238 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.0394 | 0.3712 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0009 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0088 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0147 | 0.2762 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0009 | 0.0238 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0009 | 0.0088 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0061 | 0.0201 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0009 | 0.0088 |
Trichomonas vaginalis | glucosaminephosphotransferase, putative | 0.013 | 0.0392 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0073 | 0.0994 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0038 | 0.0004 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.005 | 0.0473 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0009 | 0.0238 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0009 | 0.0238 |
Plasmodium vivax | N-acetylglucosamine-1-phosphate transferase, putative | 0.013 | 0.0392 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0009 | 0.0088 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0147 | 0.3087 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.123 umol/ml | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by EUCAST broth dilution method | ChEMBL. | 21982337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.