Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0023 | 0.0023 | 0.0042 |
Onchocerca volvulus | 0.0445 | 0.0988 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0023 | 0.0023 | 0.0042 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2426 | 0.5525 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0023 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0017 | 0.0017 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0023 | 0.0023 | 0.0042 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0021 | 0.0017 | 0.0167 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0023 | 0.0023 | 0.0042 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0023 | 0.0235 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2426 | 0.5525 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0023 | 0.0023 | 0.0042 |
Onchocerca volvulus | 0.0445 | 0.0988 | 1 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0445 | 0.0988 | 0.1789 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0445 | 0.0988 | 0.1789 |
Onchocerca volvulus | 0.0445 | 0.0988 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0023 | 0.0023 | 0.0042 |
Schistosoma mansoni | adapter molecule crk | 0.0021 | 0.0017 | 0.0167 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0021 | 0.0017 | 0.0017 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2426 | 0.5525 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2426 | 0.5525 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0445 | 0.0988 | 0.0988 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0023 | 0.0023 | 0.0023 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0023 | 0.0023 | 0.0042 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0021 | 0.0017 | 0.003 |
Echinococcus granulosus | c src tyrosine kinase | 0.0023 | 0.0023 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0023 | 0.0023 | 0.0042 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0023 | 0.0023 | 0.0042 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0445 | 0.0988 | 0.1789 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0445 | 0.0988 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0023 | 0.0235 |
Onchocerca volvulus | 0.0445 | 0.0988 | 1 | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0445 | 0.0988 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0445 | 0.0988 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0445 | 0.0988 | 0.0988 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0023 | 0.0023 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0023 | 0.0023 | 0.0042 |
Schistosoma mansoni | choline o-acyltransferase | 0.0445 | 0.0988 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.0021 | 0.0017 | 0.003 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0023 | 0.0023 | 0.0042 |
Brugia malayi | Choline O-acetyltransferase | 0.0445 | 0.0988 | 0.0988 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0445 | 0.0988 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0445 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0021 | 0.0017 | 0.0017 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0023 | 0.0235 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0023 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.438 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0023 | 0.0023 | 0.0042 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0023 | 0.0023 | 0.0042 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0445 | 0.0988 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0023 | 0.0023 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0021 | 0.0017 | 0.0017 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0445 | 0.0988 | 0.0988 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0023 | 0.0023 | 0.0042 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0021 | 0.0017 | 0.003 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0023 | 0.0023 | 0.0042 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0023 | 0.0235 |
Schistosoma mansoni | nck2/grb4 | 0.0021 | 0.0017 | 0.0167 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0021 | 0.0017 | 0.0167 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0445 | 0.0988 | 0.0988 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0021 | 0.0017 | 0.0167 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2426 | 0.5525 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0021 | 0.0017 | 0.0017 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0023 | 0.0023 | 0.0042 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0445 | 0.0988 | 0.1789 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0445 | 0.0988 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0445 | 0.0988 | 0.0988 |
Echinococcus granulosus | NCK adaptor protein | 0.0021 | 0.0017 | 0.003 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0023 | 0.0023 | 0.0042 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0013 | 0 | 0.5 |
Brugia malayi | SRC-1 | 0.0023 | 0.0023 | 0.0023 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0023 | 0.0023 | 0.0042 |
Brugia malayi | Variant SH3 domain containing protein | 0.0021 | 0.0017 | 0.0017 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0023 | 0.0023 | 0.0042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Antagonist activity at human muscarinic acetylcholine receptor 4 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC20 acetylcholine-induced calcium mobilization | ChEMBL. | 22030026 | |
Inhibition (functional) | = -3.1 % | Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobilization after 2.5 mins | ChEMBL. | 22030026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.