Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0804 | 0.0572 | 0.1076 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0126 | 0.0022 | 0.0113 |
Schistosoma mansoni | tyrosine kinase | 0.1318 | 0.0989 | 0.5098 |
Schistosoma mansoni | tyrosine kinase | 0.1318 | 0.0989 | 0.5098 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.3906 | 0.3089 | 0.6001 |
Echinococcus multilocularis | roundabout 2 | 0.0199 | 0.0081 | 0.0116 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.1726 | 0.132 | 0.1301 |
Echinococcus multilocularis | 0.0767 | 0.0543 | 0.1019 | |
Schistosoma mansoni | choline o-acyltransferase | 0.1726 | 0.132 | 0.6803 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.192 | 0.1478 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.1726 | 0.132 | 0.254 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.3906 | 0.3089 | 0.4639 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.3906 | 0.3089 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1726 | 0.132 | 0.1301 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1343 | 0.101 | 0.1933 |
Schistosoma mansoni | cell adhesion molecule | 0.0167 | 0.0055 | 0.0284 |
Echinococcus granulosus | epidermal growth factor receptor | 0.249 | 0.1941 | 0.3754 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1343 | 0.101 | 0.1933 |
Schistosoma mansoni | tyrosine kinase | 0.1343 | 0.101 | 0.5204 |
Echinococcus multilocularis | insulin receptor | 0.0804 | 0.0572 | 0.1076 |
Echinococcus multilocularis | neuroglian | 0.0158 | 0.0048 | 0.0051 |
Schistosoma mansoni | nephrin | 0.0158 | 0.0048 | 0.0247 |
Schistosoma mansoni | tyrosine kinase | 0.0804 | 0.0572 | 0.2948 |
Brugia malayi | Protein kinase domain containing protein | 0.0804 | 0.0572 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0081 | 0.0059 |
Schistosoma mansoni | tyrosine kinase | 0.249 | 0.1941 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0199 | 0.0081 | 0.0116 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.3906 | 0.3089 | 0.4639 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.1726 | 0.132 | 0.1301 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.249 | 0.1941 | 0.3754 |
Loa Loa (eye worm) | hypothetical protein | 0.1726 | 0.132 | 0.1301 |
Schistosoma mansoni | vesicular amine transporter | 0.0126 | 0.0022 | 0.0113 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6425 | 0.5133 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6425 | 0.5133 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.3906 | 0.3089 | 0.3074 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.6425 | 0.5133 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.3906 | 0.3089 | 0.6001 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.2055 | 0.1587 | 0.1569 |
Schistosoma mansoni | tyrosine kinase | 0.1318 | 0.0989 | 0.5098 |
Schistosoma mansoni | choline o-acyltransferase | 0.1726 | 0.132 | 0.6803 |
Echinococcus granulosus | insulin receptor | 0.0804 | 0.0572 | 0.1076 |
Echinococcus granulosus | neuroglian | 0.0158 | 0.0048 | 0.0051 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0126 | 0.0022 | 0.0113 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1343 | 0.101 | 0.1933 |
Onchocerca volvulus | 0.1863 | 0.1431 | 0.7044 | |
Brugia malayi | Furin-like cysteine rich region family protein | 0.249 | 0.1941 | 0.1923 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.3906 | 0.3089 | 0.3074 |
Echinococcus granulosus | choline O acetyltransferase | 0.1726 | 0.132 | 0.254 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.6425 | 0.5133 | 1 |
Echinococcus granulosus | twitchin | 0.0158 | 0.0048 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 1.2424 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.1726 | 0.132 | 0.1301 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0167 | 0.0055 | 0.0065 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.6425 | 0.5133 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1343 | 0.101 | 0.5204 |
Brugia malayi | Choline O-acetyltransferase | 0.1726 | 0.132 | 0.1301 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0055 | 0.0033 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.249 | 0.1941 | 0.1923 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0035 | 0.0013 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0804 | 0.0572 | 0.0551 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0804 | 0.0572 | 0.1076 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.2055 | 0.1587 | 0.1569 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0081 | 0.0059 |
Schistosoma mansoni | tyrosine kinase | 0.0804 | 0.0572 | 0.2948 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
2PT (functional) | = 17 uM | Anticoagulant activity in human plasma assessed as concentration required to double prothrombin-based clotting time after 30 secs using mechanical fibrometer relative to control | ChEMBL. | 22041058 |
IC50 (binding) | = 209 nM | Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry | ChEMBL. | 22041058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.