Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0193 | 0.001 | 0.0017 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0671 | 0.0762 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.0762 | 0.0753 |
Onchocerca volvulus | 0.0671 | 0.0762 | 0.5 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0671 | 0.0762 | 0.0753 |
Schistosoma mansoni | tyrosine kinase | 0.0321 | 0.0211 | 0.2676 |
Schistosoma mansoni | tyrosine kinase | 0.0604 | 0.0656 | 0.8585 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0604 | 0.0656 | 0.0647 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0671 | 0.0762 | 0.0753 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0604 | 0.0656 | 0.1185 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0604 | 0.0656 | 0.0647 |
Onchocerca volvulus | 0.0671 | 0.0762 | 0.5 | |
Onchocerca volvulus | 0.0671 | 0.0762 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0671 | 0.0762 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0671 | 0.0762 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0671 | 0.0762 | 0.1395 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0671 | 0.0762 | 0.1395 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0671 | 0.0762 | 0.0753 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0671 | 0.0762 | 0.0753 |
Onchocerca volvulus | 0.0671 | 0.0762 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0321 | 0.0211 | 0.2676 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0671 | 0.0762 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3661 | 0.5463 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0671 | 0.0762 | 0.138 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3661 | 0.5463 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3661 | 0.5463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6546 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0324 | 0.0216 | 0.0379 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0604 | 0.0656 | 0.12 |
Schistosoma mansoni | tyrosine kinase | 0.0324 | 0.0216 | 0.2747 |
Brugia malayi | Choline O-acetyltransferase | 0.0671 | 0.0762 | 0.0753 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0324 | 0.0216 | 0.0396 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3661 | 0.5463 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0671 | 0.0762 | 0.0753 |
Schistosoma mansoni | tyrosine kinase | 0.0321 | 0.0211 | 0.2676 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0671 | 0.0762 | 0.0753 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0671 | 0.0762 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0193 | 0.001 | 0.0017 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3661 | 0.5463 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0324 | 0.0216 | 0.2747 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0671 | 0.0762 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0671 | 0.0762 | 0.138 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0324 | 0.0216 | 0.0379 |
Schistosoma mansoni | choline o-acyltransferase | 0.0671 | 0.0762 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | <= 10 mm | Antimicrobial activity against Escherichia coli DC0 after 24 hrs by Kirby-Bauer agar diffusion assay | ChEMBL. | 21859126 |
IZ (functional) | <= 10 mm | Antimicrobial activity against Escherichia coli DC2 after 24 hrs by Kirby-Bauer agar diffusion assay | ChEMBL. | 21859126 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.