Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.159 | 0.4835 | 0.4588 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1858 | 0.5658 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1858 | 0.5658 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1858 | 0.5658 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0855 | 0.2577 | 0.533 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0855 | 0.2577 | 0.3387 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.159 | 0.4835 | 0.4588 |
Schistosoma mansoni | tyrosine kinase | 0.0855 | 0.2577 | 0.533 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0341 | 0.0999 | 0.0568 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0341 | 0.0999 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0341 | 0.0999 | 0.0568 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1858 | 0.5658 | 1 |
Onchocerca volvulus | 0.0341 | 0.0999 | 1 | |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0509 | 0.1515 | 0.1107 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.159 | 0.4835 | 0.8234 |
Onchocerca volvulus | 0.0341 | 0.0999 | 1 | |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0341 | 0.0999 | 0.0568 |
Schistosoma mansoni | tyrosine kinase | 0.0845 | 0.2547 | 0.5267 |
Schistosoma mansoni | choline o-acyltransferase | 0.0341 | 0.0999 | 0.2066 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0341 | 0.0999 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0341 | 0.0999 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.3272 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0341 | 0.0999 | 0.2066 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1858 | 0.5658 | 1 |
Onchocerca volvulus | 0.0341 | 0.0999 | 1 | |
Echinococcus multilocularis | insulin receptor | 0.0509 | 0.1515 | 0.1107 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0509 | 0.1515 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.0999 | 0.0568 |
Brugia malayi | Choline O-acetyltransferase | 0.0341 | 0.0999 | 0.0568 |
Brugia malayi | Protein kinase domain containing protein | 0.0509 | 0.1515 | 0.1108 |
Echinococcus granulosus | insulin receptor | 0.0509 | 0.1515 | 0.1107 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0509 | 0.1515 | 0.1107 |
Brugia malayi | Choline O-acetyltransferase | 0.0341 | 0.0999 | 0.0568 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0341 | 0.0999 | 0.5 |
Echinococcus multilocularis | 0.0492 | 0.1463 | 0.0996 | |
Schistosoma mansoni | tyrosine kinase | 0.159 | 0.4835 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0341 | 0.0999 | 0.0568 |
Schistosoma mansoni | tyrosine kinase | 0.0845 | 0.2547 | 0.5267 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0341 | 0.0999 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0845 | 0.2547 | 0.5267 |
Schistosoma mansoni | tyrosine kinase | 0.0509 | 0.1515 | 0.3133 |
Echinococcus granulosus | epidermal growth factor receptor | 0.159 | 0.4835 | 0.8234 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0855 | 0.2577 | 0.3387 |
Schistosoma mansoni | tyrosine kinase | 0.0509 | 0.1515 | 0.3133 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0341 | 0.0999 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0855 | 0.2577 | 0.3387 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0154 | 0.0426 | 0.0619 |
Onchocerca volvulus | 0.0341 | 0.0999 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.