Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SET domain containing protein | 0.0363 | 0.3931 | 0.511 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0767 | 0.1016 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0767 | 0.083 |
Brugia malayi | glutathione reductase | 0.0049 | 0.014 | 0.0182 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.0148 | 0.0692 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.2136 | 0.3265 |
Mycobacterium ulcerans | putative regulatory protein | 0.0037 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.0767 | 0.0997 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.2136 | 0.3265 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0199 | 0.1949 | 0.2957 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.2136 | 0.2643 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0767 | 0.0997 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.014 | 0.0182 |
Plasmodium vivax | SET domain protein, putative | 0.0199 | 0.1949 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0199 | 0.1949 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1949 | 0.2395 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0767 | 0.3589 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.0767 | 0.0997 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0767 | 0.1016 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0767 | 0.083 |
Trichomonas vaginalis | set domain proteins, putative | 0.0867 | 1 | 0.5 |
Schistosoma mansoni | single-minded | 0.005 | 0.0157 | 0.0015 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0199 | 0.1949 | 0.9123 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.0767 | 0.1016 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.0767 | 0.083 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.2136 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0199 | 0.1949 | 0.2957 |
Brugia malayi | hypothetical protein | 0.0168 | 0.1578 | 0.2052 |
Brugia malayi | PAS domain containing protein | 0.005 | 0.0157 | 0.0204 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0155 | 0.1421 | 0.1697 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.2136 | 0.2777 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.014 | 0.5 |
Onchocerca volvulus | 0.0555 | 0.6238 | 0.6238 | |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.3718 | 0.4738 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0767 | 0.3589 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0675 | 0.7693 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0199 | 0.1949 | 0.2533 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.2136 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.0767 | 0.3464 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.2136 | 0.2777 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.2136 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.0148 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0767 | 0.083 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0767 | 0.3589 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0555 | 0.6238 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.0767 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0767 | 0.3589 |
Brugia malayi | Pre-SET motif family protein | 0.0675 | 0.7693 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0199 | 0.1949 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0155 | 0.1421 | 0.1848 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0191 | 0.1861 | 0.871 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.005 | 0.0157 | 0.0015 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0767 | 0.0997 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0767 | 0.3589 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.2136 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.2136 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.2136 | 0.2643 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0199 | 0.1949 | 0.9123 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0767 | 0.1016 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0199 | 0.1949 | 0.9123 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.3842 | 0.4902 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0767 | 0.1016 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.2136 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0767 | 0.3589 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0767 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1578 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15 nM | In vitro inhibitory activity against human carbonic anhydrase II (hCAII) | ChEMBL. | 15139757 |
Ki (binding) | = 15 nM | In vitro inhibitory activity against human carbonic anhydrase II (hCAII) | ChEMBL. | 15139757 |
Ki (binding) | = 41 nM | In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV) | ChEMBL. | 15139757 |
Ki (binding) | = 41 nM | In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV) | ChEMBL. | 15139757 |
Ki (binding) | = 940 nM | In vitro inhibitory activity against human carbonic anhydrase I (hCAI) | ChEMBL. | 15139757 |
Ki (binding) | = 940 nM | In vitro inhibitory activity against human carbonic anhydrase I (hCAI) | ChEMBL. | 15139757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.