Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0696 | 0.1113 | 0.6718 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0031 | 0.0031 |
Brugia malayi | Choline O-acetyltransferase | 0.0696 | 0.1113 | 0.1113 |
Brugia malayi | Choline O-acetyltransferase | 0.0696 | 0.1113 | 0.1113 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0927 | 0.1504 | 0.2671 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0041 | 0.0004 | 0.5 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0696 | 0.1113 | 0.1974 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0696 | 0.1113 | 0.1974 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0041 | 0.0004 | 0.0004 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1015 | 0.1655 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3356 | 0.5621 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0696 | 0.1113 | 0.1974 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0031 | 0.0031 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0041 | 0.0004 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0041 | 0.0004 | 0.0004 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1015 | 0.1655 | 0.2939 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0696 | 0.1113 | 0.1113 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.0262 | 0.2355 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1015 | 0.1655 | 0.2939 |
Echinococcus multilocularis | geminin | 0.0194 | 0.0262 | 0.046 |
Onchocerca volvulus | 0.0696 | 0.1113 | 1 | |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0041 | 0.0004 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0041 | 0.0004 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0696 | 0.1113 | 0.1113 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0696 | 0.1113 | 0.1974 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0696 | 0.1113 | 0.6718 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0696 | 0.1113 | 0.1974 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0.0004 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.016 | 0.0206 | 0.1847 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0696 | 0.1113 | 0.1974 |
Loa Loa (eye worm) | hypothetical protein | 0.5941 | 1 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0696 | 0.1113 | 0.1974 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0186 | 0.0249 | 0.0249 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0696 | 0.1113 | 0.1974 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0696 | 0.1113 | 0.1113 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0041 | 0.0004 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0696 | 0.1113 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1015 | 0.1655 | 0.2939 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0696 | 0.1113 | 0.6718 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0186 | 0.0249 | 0.0437 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1015 | 0.1655 | 0.1655 |
Onchocerca volvulus | 0.0696 | 0.1113 | 1 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0696 | 0.1113 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0186 | 0.0249 | 0.0437 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0186 | 0.0249 | 0.0437 |
Schistosoma mansoni | alpha-glucosidase | 0.016 | 0.0206 | 0.1847 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0.0004 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0696 | 0.1113 | 0.1974 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0.0004 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0041 | 0.0004 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3356 | 0.5621 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3356 | 0.5621 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0031 | 0.0031 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1015 | 0.1655 | 0.2939 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0696 | 0.1113 | 0.1974 |
Echinococcus granulosus | choline O acetyltransferase | 0.0696 | 0.1113 | 0.1974 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1015 | 0.1655 | 0.1655 |
Onchocerca volvulus | 0.0696 | 0.1113 | 1 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0186 | 0.0249 | 0.0249 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0041 | 0.0004 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0696 | 0.1113 | 0.1113 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.0262 | 0.2355 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3356 | 0.5621 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0696 | 0.1113 | 0.1974 |
Echinococcus granulosus | geminin | 0.0194 | 0.0262 | 0.046 |
Onchocerca volvulus | 0.0696 | 0.1113 | 1 | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0696 | 0.1113 | 0.6718 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3356 | 0.5621 | 1 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0696 | 0.1113 | 0.1974 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0041 | 0.0004 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0041 | 0.0004 | 0.0036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.