Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline O-acetyltransferase | 0.0337 | 0.0983 | 0.0758 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0422 | 0.1258 | 0.1258 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0337 | 0.0983 | 0.0983 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1721 | 0.5482 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0337 | 0.0983 | 0.0983 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0337 | 0.0983 | 0.1738 |
Schistosoma mansoni | choline o-acyltransferase | 0.0337 | 0.0983 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0422 | 0.1258 | 0.104 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0337 | 0.0983 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.3111 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0422 | 0.1258 | 0.0612 |
Echinococcus granulosus | choline O acetyltransferase | 0.0337 | 0.0983 | 0.1738 |
Schistosoma mansoni | choline o-acyltransferase | 0.0337 | 0.0983 | 1 |
Onchocerca volvulus | 0.0337 | 0.0983 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1721 | 0.5482 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0337 | 0.0983 | 0.0758 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1721 | 0.5482 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1721 | 0.5482 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0422 | 0.1258 | 0.2244 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1721 | 0.5482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.0983 | 0.0983 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0422 | 0.1258 | 0.0612 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0422 | 0.1258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0243 | 0.0243 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0422 | 0.1258 | 0.2244 |
Onchocerca volvulus | 0.0337 | 0.0983 | 1 | |
Onchocerca volvulus | 0.0337 | 0.0983 | 1 | |
Onchocerca volvulus | 0.0337 | 0.0983 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.6 uM | Inhibition of aggrecanase-1 | ChEMBL. | 21982494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.