Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline o-acyltransferase | 0.0423 | 0.0969 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0577 | 0.1375 | 1 |
Onchocerca volvulus | 0.0423 | 0.0969 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2096 | 0.5373 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0423 | 0.0969 | 0.0969 |
Brugia malayi | Choline O-acetyltransferase | 0.0423 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0423 | 0.0969 | 0.0969 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0577 | 0.1375 | 0.0922 |
Echinococcus granulosus | choline O acetyltransferase | 0.0423 | 0.0969 | 0.1803 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0577 | 0.1375 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.3853 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0423 | 0.0969 | 0.0969 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0423 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.0969 | 0.0969 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2096 | 0.5373 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0423 | 0.0969 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2096 | 0.5373 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2096 | 0.5373 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0577 | 0.1375 | 0.2558 |
Onchocerca volvulus | 0.0423 | 0.0969 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2096 | 0.5373 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0234 | 0.0234 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0577 | 0.1375 | 0.1375 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0577 | 0.1375 | 0.2558 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0577 | 0.1375 | 0.1375 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0423 | 0.0969 | 0.1803 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0234 | 0.0234 |
Onchocerca volvulus | 0.0423 | 0.0969 | 0.5 | |
Onchocerca volvulus | 0.0423 | 0.0969 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0294 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.