Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.003 | 0.003 |
Brugia malayi | Choline O-acetyltransferase | 0.0688 | 0.1018 | 0.1018 |
Schistosoma mansoni | choline o-acyltransferase | 0.0688 | 0.1018 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1091 | 0.1651 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0688 | 0.1018 | 0.1018 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0162 | 0.0162 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1091 | 0.1651 | 0.1603 |
Onchocerca volvulus | 0.0688 | 0.1018 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.003 | 0.003 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0162 | 0.0162 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1091 | 0.1651 | 0.1603 |
Onchocerca volvulus | 0.0688 | 0.1018 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3201 | 0.497 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0688 | 0.1018 | 0.1018 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1091 | 0.1651 | 0.1603 |
Onchocerca volvulus | 0.0688 | 0.1018 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.6398 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3201 | 0.497 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0688 | 0.1018 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0688 | 0.1018 | 0.1018 |
Onchocerca volvulus | 0.0688 | 0.1018 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1091 | 0.1651 | 0.1651 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3201 | 0.497 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3201 | 0.497 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3201 | 0.497 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1091 | 0.1651 | 0.1651 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1091 | 0.1651 | 0.1603 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0688 | 0.1018 | 0.1018 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0688 | 0.1018 | 0.1018 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.003 | 0.003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.