Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2424 | 0.513 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2424 | 0.513 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1257 | 0.2432 | 0.1655 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2424 | 0.513 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0607 | 0.0931 | 0.1815 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0607 | 0.0931 | 0.1815 |
Onchocerca volvulus | 0.0607 | 0.0931 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1257 | 0.2432 | 0.474 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1257 | 0.2432 | 0.3574 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1257 | 0.2432 | 1 |
Onchocerca volvulus | 0.0607 | 0.0931 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0607 | 0.0931 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1257 | 0.2432 | 0.1655 |
Schistosoma mansoni | choline o-acyltransferase | 0.0607 | 0.0931 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1257 | 0.2432 | 0.474 |
Onchocerca volvulus | 0.0607 | 0.0931 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2424 | 0.513 | 1 |
Onchocerca volvulus | 0.0607 | 0.0931 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2424 | 0.513 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1257 | 0.2432 | 0.3574 |
Loa Loa (eye worm) | hypothetical protein | 0.4531 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3078 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.