Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0136 | 0.3258 | 0.4427 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0086 | 0.0947 | 0.1287 |
Echinococcus multilocularis | zinc finger protein | 0.0074 | 0.0435 | 0.0592 |
Echinococcus granulosus | zinc finger protein | 0.0074 | 0.0435 | 0.0592 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0136 | 0.3258 | 0.4427 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0108 | 0.1955 | 0.2111 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0067 | 0.0106 | 0.0114 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0086 | 0.0947 | 0.1287 |
Schistosoma mansoni | bromodomain containing protein | 0.024 | 0.7978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4087 | 0.4413 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0227 | 0.736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.9262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.4417 | 0.4769 |
Brugia malayi | Bromodomain containing protein | 0.0145 | 0.3667 | 0.2673 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0618 | 0.0774 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0227 | 0.736 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0074 | 0.0435 | 0.0546 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0086 | 0.0947 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3679 | 0.3972 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.