Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.015 | 0.4363 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.015 | 0.4363 | 0.4363 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.4363 | 0.4363 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.015 | 0.4363 | 0.2201 |
Plasmodium vivax | polyprenol reductase, putative | 0.015 | 0.4363 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.015 | 0.4363 | 0.2201 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0281 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.015 | 0.4363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.015 | 0.4363 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0113 | 0.2772 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.015 | 0.4363 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.2772 | 0.6355 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.015 | 0.4363 | 1 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.015 | 0.4363 | 0.4363 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.015 | 0.4363 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.2772 | 0.2772 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.015 | 0.4363 | 1 |
Onchocerca volvulus | 0.015 | 0.4363 | 1 | |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.015 | 0.4363 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0281 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.2772 | 0.2772 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.015 | 0.4363 | 0.2201 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.2772 | 0.6355 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.015 | 0.4363 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0281 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.015 | 0.4363 | 0.2201 |
Trichomonas vaginalis | conserved hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.015 | 0.4363 | 0.2201 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.015 | 0.4363 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0281 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0281 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.