Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Synaptic glycoprotein SC2 | 0.015 | 0.4363 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.2772 | 0.6355 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.2772 | 0.2772 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.015 | 0.4363 | 0.2201 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.4363 | 0.4363 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.015 | 0.4363 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0281 | 1 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.015 | 0.4363 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.015 | 0.4363 | 1 |
Onchocerca volvulus | 0.015 | 0.4363 | 1 | |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0281 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.015 | 0.4363 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.015 | 0.4363 | 0.2201 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0113 | 0.2772 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.015 | 0.4363 | 0.2201 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.015 | 0.4363 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.2772 | 0.6355 |
Plasmodium vivax | polyprenol reductase, putative | 0.015 | 0.4363 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.015 | 0.4363 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0281 | 1 | 1 |
Plasmodium falciparum | polyprenol reductase, putative | 0.015 | 0.4363 | 0.5 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.015 | 0.4363 | 0.4363 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0281 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.2772 | 0.2772 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.015 | 0.4363 | 0.2201 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.015 | 0.4363 | 0.2201 |
Trichomonas vaginalis | conserved hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.015 | 0.4363 | 1 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.015 | 0.4363 | 0.4363 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0049 | 0 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.015 | 0.4363 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4363 | 0.2201 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.