Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.1437 | 0.683 | 0.6829 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.0963 | 0.2061 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0034 | 0.0029 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0843 | 0.3947 | 0.3943 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2091 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0034 | 0.0022 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.0863 | 0.0858 |
Echinococcus granulosus | carbonic anhydrase | 0.0843 | 0.3947 | 0.3947 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0034 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0034 | 0.0034 |
Onchocerca volvulus | Putative sulfate transporter | 0.0203 | 0.0845 | 0.8424 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0056 | 0.0038 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0234 | 0.0997 | 0.2135 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0034 | 0.0034 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0056 | 0.0038 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1437 | 0.683 | 0.9547 |
Toxoplasma gondii | hypothetical protein | 0.0843 | 0.3947 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.023 | 0.0976 | 0.0972 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0034 | 0.0022 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0843 | 0.3947 | 0.3943 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0034 | 0.0029 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1437 | 0.683 | 1 |
Onchocerca volvulus | 0.0036 | 0.0034 | 0.0289 | |
Onchocerca volvulus | 0.0036 | 0.0034 | 0.0289 | |
Echinococcus granulosus | carbonic anhydrase II | 0.2091 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 0.1002 | 0.1359 |
Schistosoma mansoni | hypothetical protein | 0.0843 | 0.3947 | 0.3943 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0034 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Entamoeba histolytica | ankyrin, putative | 0.007 | 0.02 | 0.0244 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0843 | 0.3947 | 0.3943 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0673 | 0.0668 |
Mycobacterium leprae | PROBABLE TRANSFERASE | 0.0067 | 0.0187 | 0.0225 |
Echinococcus granulosus | carbonic anhydrase | 0.0843 | 0.3947 | 0.3947 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0034 | 0.0029 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0843 | 0.3947 | 0.3943 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0034 | 0.0073 |
Echinococcus multilocularis | carbonic anhydrase | 0.0843 | 0.3947 | 0.3943 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0056 | 0.0053 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0773 | 0.3607 | 0.7922 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0034 | 0.0022 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2091 | 1 | 1 |
Onchocerca volvulus | 0.0203 | 0.0845 | 0.8424 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2091 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.2091 | 1 | 1 |
Echinococcus granulosus | dynactin 5 p25 | 0.007 | 0.02 | 0.02 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0056 | 0.0038 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.023 | 0.0976 | 0.0972 |
Toxoplasma gondii | inorganic anion transporter, sulfate permease (SulP) family protein | 0.0032 | 0.0018 | 0.0033 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0034 | 0.0029 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2091 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1504 | 0.7153 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1437 | 0.683 | 0.682 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0034 | 0.0016 |
Schistosoma mansoni | carbonic anhydrase | 0.0843 | 0.3947 | 0.3943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.0187 | 0.0215 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.004 | 0.0056 | 0.0032 |
Echinococcus multilocularis | carbonic anhydrase | 0.0843 | 0.3947 | 0.3943 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0034 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1504 | 0.7153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0843 | 0.3947 | 0.3943 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0034 | 0.0029 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0034 | 0.0029 |
Onchocerca volvulus | 0.0036 | 0.0034 | 0.0289 | |
Loa Loa (eye worm) | hypothetical protein | 0.2017 | 0.964 | 0.964 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0034 | 0.0029 |
Entamoeba histolytica | acetyltransferase, putative | 0.007 | 0.02 | 0.0244 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0843 | 0.3947 | 0.3943 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0034 | 0.0016 |
Echinococcus granulosus | carbonic anhydrase | 0.0843 | 0.3947 | 0.3947 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0005 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0843 | 0.3947 | 0.3943 |
Mycobacterium tuberculosis | Possible siderophore-binding protein | 0.004 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0673 | 0.0668 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0056 | 0.0022 |
Chlamydia trachomatis | sulfate transporter | 0.0032 | 0.0018 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.007 | 0.02 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0843 | 0.3947 | 0.3943 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2091 | 1 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0234 | 0.0997 | 0.1417 |
Mycobacterium ulcerans | transferase | 0.0067 | 0.0187 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0034 | 0.0029 |
Onchocerca volvulus | 0.0235 | 0.1002 | 1 | |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1437 | 0.683 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0673 | 0.0668 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2091 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0843 | 0.3947 | 0.3943 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0034 | 0.0029 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0843 | 0.3947 | 0.3943 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.0863 | 0.0858 |
Onchocerca volvulus | 0.0067 | 0.0187 | 0.1825 | |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0034 | 0.0029 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0843 | 0.3947 | 0.3943 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0899 | 0.4221 | 0.9284 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0966 | 0.4544 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0034 | 0.0022 |
Echinococcus multilocularis | carbonic anhydrase | 0.0843 | 0.3947 | 0.3943 |
Plasmodium vivax | sulfate transporter, putative | 0.0032 | 0.0018 | 0.4487 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2091 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0034 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1504 | 0.7153 | 1 |
Trichomonas vaginalis | maltose O-acetyltransferase, putative | 0.0067 | 0.0187 | 0.0215 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.007 | 0.02 | 0.0368 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.007 | 0.02 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.0673 | 0.0673 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0034 | 0.0022 |
Plasmodium falciparum | carbonic anhydrase | 0.0843 | 0.3947 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.