Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0769 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.247 | 0.247 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0163 | 0.0255 | 0.0255 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0769 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0301 | 0.247 | 0.247 |
Echinococcus granulosus | cathepsin b | 0.0769 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0301 | 0.247 | 0.247 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0208 | 0.0986 | 0.0986 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0301 | 0.247 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0301 | 0.247 | 0.2242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0165 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0301 | 0.247 | 0.247 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0769 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.247 | 0.247 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0769 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0288 | 0.2271 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0288 | 0.2271 | 0.2271 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0301 | 0.247 | 0.2242 |
Giardia lamblia | Cathepsin B precursor | 0.0288 | 0.2271 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0163 | 0.0255 | 0.0255 |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0301 | 0.247 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0301 | 0.247 | 0.2242 |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0301 | 0.247 | 0.2242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0288 | 0.2271 | 0.9083 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0288 | 0.2271 | 0.9083 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0165 | 0.0294 | 0.0294 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1069 | 0.1069 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0301 | 0.247 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.247 | 0.247 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0165 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | ctsf protein | 0.0301 | 0.247 | 0.247 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0208 | 0.0986 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0301 | 0.247 | 0.2242 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0769 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0301 | 0.247 | 0.2242 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.247 | 0.247 |
Plasmodium vivax | vivapain-2 | 0.0301 | 0.247 | 1 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0301 | 0.247 | 0.247 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0242 | 0.1535 | 0.1535 |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0275 | 0.2058 | 0.833 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0301 | 0.247 | 0.2242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0208 | 0.0986 | 0.3182 |
Onchocerca volvulus | Cathepsin F homolog | 0.0301 | 0.247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0769 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0301 | 0.247 | 1 |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0301 | 0.247 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0165 | 0.0294 | 0.0294 |
Echinococcus multilocularis | cysteine protease | 0.0301 | 0.247 | 0.2242 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0208 | 0.0986 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0288 | 0.2271 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0208 | 0.0986 | 0.0986 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0769 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0301 | 0.247 | 0.2242 |
Echinococcus granulosus | cathepsin b | 0.0769 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0288 | 0.2271 | 0.2271 |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0301 | 0.247 | 0.2242 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0301 | 0.247 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0301 | 0.247 | 0.247 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0986 | 0.0986 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0208 | 0.0986 | 0.0986 |
Leishmania major | cysteine peptidase A (CPA) | 0.0301 | 0.247 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0208 | 0.0986 | 0.0986 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.247 | 0.247 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.247 | 0.247 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0301 | 0.247 | 0.2242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0301 | 0.247 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0301 | 0.247 | 0.2242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0301 | 0.247 | 0.2242 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.247 | 0.247 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0208 | 0.0986 | 0.0714 |
Entamoeba histolytica | cysteine protease, putative | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0301 | 0.247 | 0.247 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0208 | 0.0986 | 0.0986 |
Onchocerca volvulus | 0.0208 | 0.0986 | 0.3993 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0288 | 0.2271 | 0.2037 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0301 | 0.247 | 0.2242 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0301 | 0.247 | 0.247 |
Onchocerca volvulus | 0.0301 | 0.247 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0242 | 0.1535 | 0.1535 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0165 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0986 | 0.0986 |
Echinococcus granulosus | cathepsin l1 | 0.0208 | 0.0986 | 0.0714 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.247 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0301 | 0.247 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.522 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.423 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.41 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.398 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.296 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.185 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.