Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0234 | 0.2336 | 0.2336 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0234 | 0.2336 | 0.2939 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0204 | 0.1997 | 0.8874 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0234 | 0.2336 | 0.2318 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0031 | 0.0073 | 0.0011 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0428 | 0.4502 | 0.4502 |
Brugia malayi | Thioredoxin reductase | 0.0089 | 0.0723 | 0.0702 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0194 | 0.1894 | 0.1876 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0031 | 0.0073 | 0.6126 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0194 | 0.1894 | 0.1831 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0428 | 0.4502 | 0.5756 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0194 | 0.1894 | 0.1894 |
Plasmodium falciparum | thioredoxin reductase | 0.0089 | 0.0723 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0428 | 0.4502 | 0.4489 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.099 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0724 | 0.7794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0087 | 0.07 | 0.0812 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0263 | 0.0246 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.0118 | 0.1616 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0428 | 0.4502 | 0.5736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0428 | 0.4502 | 0.4502 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0428 | 0.4502 | 0.4502 |
Echinococcus multilocularis | geminin | 0.0178 | 0.1709 | 0.2156 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0194 | 0.1894 | 0.2367 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2336 | 0.2336 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0118 | 0.0106 |
Onchocerca volvulus | 0.0194 | 0.1894 | 0.1831 | |
Treponema pallidum | NADH oxidase | 0.0031 | 0.0073 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0194 | 0.1894 | 0.2359 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0077 | 0.0005 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0077 | 0.0053 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Brugia malayi | nuclear receptor NHR-88 | 0.0428 | 0.4502 | 0.4489 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0428 | 0.4502 | 0.4489 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0428 | 0.4502 | 0.5741 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0194 | 0.1894 | 0.1894 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0428 | 0.4502 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0023 | 0.0295 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0428 | 0.4502 | 0.4489 |
Brugia malayi | nuclear hormone receptor | 0.0428 | 0.4502 | 0.4489 |
Brugia malayi | steroid hormone receptor | 0.0889 | 0.9637 | 0.9636 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0428 | 0.4502 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2336 | 0.2336 |
Brugia malayi | nuclear receptor RXR | 0.0234 | 0.2336 | 0.2318 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0031 | 0.0073 | 0.099 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0724 | 0.7794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0428 | 0.4502 | 0.5736 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0428 | 0.4502 | 0.5756 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.0118 | 0.0186 |
Onchocerca volvulus | 0.0248 | 0.2497 | 0.2438 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0428 | 0.4502 | 0.5741 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0194 | 0.1894 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1474 | 0.1474 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0031 | 0.0073 | 0.0716 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0118 | 0.0106 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0035 | 0.0118 | 0.0518 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0428 | 0.4502 | 0.4502 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0428 | 0.4502 | 0.4502 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0194 | 0.1894 | 0.2395 |
Onchocerca volvulus | 0.0428 | 0.4502 | 0.4459 | |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0031 | 0.0073 | 0.099 |
Brugia malayi | hypothetical protein | 0.0234 | 0.2336 | 0.2318 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0428 | 0.4502 | 0.5756 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0023 | 0.0295 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0263 | 0.0241 |
Schistosoma mansoni | nuclear hormone receptor | 0.0428 | 0.4502 | 0.5736 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0428 | 0.4502 | 0.5741 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Schistosoma mansoni | nuclear receptor | 0.0194 | 0.1894 | 0.2359 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0194 | 0.1894 | 0.2395 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.1123 | 0.1103 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0194 | 0.1894 | 0.1876 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0031 | 0.0073 | 0.099 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0234 | 0.2336 | 0.2318 |
Schistosoma mansoni | thyroid hormone receptor | 0.0428 | 0.4502 | 0.5736 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0023 | 0.0295 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0118 | 0.0041 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0031 | 0.0073 | 0.0318 |
Brugia malayi | conserved hypotetical protein | 0.0194 | 0.1894 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0023 | 0.0023 |
Leishmania major | pyruvate kinase | 0.0035 | 0.0118 | 0.1616 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0077 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0428 | 0.4502 | 0.4489 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0263 | 0.0292 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0194 | 0.1894 | 0.1876 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0194 | 0.1894 | 0.2367 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0655 | 0.7029 | 0.9011 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.1474 | 0.1854 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0428 | 0.4502 | 0.4459 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0031 | 0.0073 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0194 | 0.1894 | 0.2359 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0204 | 0.1997 | 0.8874 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0204 | 0.1997 | 0.8874 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0194 | 0.1894 | 0.2395 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0226 | 0.225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2336 | 0.2336 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.099 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0428 | 0.4502 | 0.4489 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0031 | 0.0073 | 0.6126 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1709 | 0.2119 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0031 | 0.0073 | 0.099 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0428 | 0.4502 | 0.5741 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2336 | 0.2336 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0031 | 0.0073 | 0.005 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0234 | 0.2336 | 0.2931 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.009 | 0.0729 | 0.0893 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 0.2497 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0204 | 0.1997 | 0.8874 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Echinococcus granulosus | FTZ F1 alpha | 0.0428 | 0.4502 | 0.5741 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Brugia malayi | hypothetical protein | 0.0234 | 0.2336 | 0.2318 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0023 | 0.0295 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0194 | 0.1894 | 0.2395 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.009 | 0.0729 | 0.086 |
Plasmodium falciparum | glutathione reductase | 0.0089 | 0.0723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0922 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0089 | 0.0723 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0035 | 0.0118 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0428 | 0.4502 | 0.5736 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0194 | 0.1894 | 0.1876 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0087 | 0.07 | 0.0856 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1709 | 0.2119 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0428 | 0.4502 | 0.4489 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0194 | 0.1894 | 0.1894 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0077 | 0.1048 |
Brugia malayi | hypothetical protein | 0.0194 | 0.1894 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Brugia malayi | tailless protein | 0.0194 | 0.1894 | 0.1876 |
Trypanosoma brucei | trypanothione reductase | 0.0089 | 0.0723 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0031 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0077 | 0.0005 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0077 | 0.0017 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0118 | 0.0059 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0428 | 0.4502 | 0.5736 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0226 | 0.225 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0077 | 0.1048 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0031 | 0.0073 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Schistosoma mansoni | zinc finger protein | 0.0194 | 0.1894 | 0.2359 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0263 | 0.0292 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0889 | 0.9637 | 0.9637 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0724 | 0.7794 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0035 | 0.0118 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1474 | 0.1474 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0263 | 0.0246 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.0118 | 0.1361 |
Leishmania major | pyruvate kinase | 0.0035 | 0.0118 | 0.1616 |
Loa Loa (eye worm) | glutathione reductase | 0.0089 | 0.0723 | 0.0723 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.0118 | 0.1616 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0428 | 0.4502 | 0.4489 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0077 | 0.0054 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0031 | 0.0073 | 0.099 |
Brugia malayi | nuclear receptor RXR | 0.0194 | 0.1894 | 0.1876 |
Brugia malayi | hypothetical protein | 0.0194 | 0.1894 | 0.1876 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0428 | 0.4502 | 0.5756 |
Schistosoma mansoni | nuclear hormone receptor | 0.0194 | 0.1894 | 0.2359 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0077 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0031 | 0.0073 | 0.6126 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0263 | 0.0257 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0035 | 0.0118 | 0.1616 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0194 | 0.1894 | 0.1876 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0031 | 0.0073 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Brugia malayi | nuclear hormone receptor | 0.0194 | 0.1894 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0428 | 0.4502 | 0.5756 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0077 | 0.0053 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0428 | 0.4502 | 0.4502 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0031 | 0.0073 | 0.0716 |
Schistosoma mansoni | thyroid hormone receptor | 0.0428 | 0.4502 | 0.5736 |
Plasmodium falciparum | thioredoxin reductase | 0.0031 | 0.0073 | 0.099 |
Echinococcus granulosus | geminin | 0.0178 | 0.1709 | 0.2128 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0428 | 0.4502 | 0.5736 |
Loa Loa (eye worm) | DR-78 | 0.0194 | 0.1894 | 0.1894 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0194 | 0.1894 | 0.2395 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0226 | 0.225 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0194 | 0.1894 | 0.1876 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0118 | 0.0118 |
Plasmodium falciparum | glutathione reductase | 0.0031 | 0.0073 | 0.099 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0118 | 0.007 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.1474 | 0.1824 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0087 | 0.07 | 0.0679 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0428 | 0.4502 | 0.5741 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0428 | 0.4502 | 0.4502 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0428 | 0.4502 | 0.4459 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0234 | 0.2336 | 0.2931 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0089 | 0.0723 | 0.3208 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0428 | 0.4502 | 0.5756 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0089 | 0.0723 | 0.0723 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0035 | 0.0118 | 0.0095 |
Schistosoma mansoni | nuclear receptor | 0.0194 | 0.1894 | 0.2359 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.1123 | 0.1123 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0428 | 0.4502 | 0.4489 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0428 | 0.4502 | 0.4489 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0234 | 0.2336 | 0.2965 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0194 | 0.1894 | 0.1831 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0118 | 0.0059 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0263 | 0.0257 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0031 | 0.0073 | 0.099 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0204 | 0.1997 | 0.8874 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0428 | 0.4502 | 0.5736 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0001 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0087 | 0.07 | 0.0822 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0118 | 0.0041 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.1123 | 0.1123 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0089 | 0.0723 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.0118 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0194 | 0.1894 | 0.2367 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.1474 | 0.1455 |
Mycobacterium tuberculosis | Probable reductase | 0.0204 | 0.1997 | 0.8874 |
Brugia malayi | ecdysone receptor | 0.0194 | 0.1894 | 0.1876 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0035 | 0.0118 | 0.0518 |
Leishmania major | trypanothione reductase | 0.0089 | 0.0723 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0031 | 0.0073 | 0.099 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0194 | 0.1894 | 0.2395 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0226 | 0.225 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0035 | 0.0118 | 0.1616 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0428 | 0.4502 | 0.5756 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0428 | 0.4502 | 0.5756 |
Brugia malayi | glutathione reductase | 0.0089 | 0.0723 | 0.0702 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0428 | 0.4502 | 0.5736 |
Onchocerca volvulus | 0.0194 | 0.1894 | 0.1831 | |
Onchocerca volvulus | 0.0087 | 0.07 | 0.0628 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0922 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0194 | 0.1894 | 0.2367 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0031 | 0.0073 | 0.099 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0428 | 0.4502 | 0.5736 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.4502 | 0.4502 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0194 | 0.1894 | 0.2359 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.0118 | 0.1616 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0031 | 0.0073 | 0.099 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0023 | 0.0295 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0428 | 0.4502 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0204 | 0.1997 | 0.8874 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0428 | 0.4502 | 0.5741 |
Plasmodium vivax | glutathione reductase, putative | 0.0089 | 0.0723 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0031 | 0.0073 | 0.6126 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.0118 | 0.1361 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.0118 | 0.0186 |
Toxoplasma gondii | thioredoxin reductase | 0.0089 | 0.0723 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.2161 | 0.2161 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0428 | 0.4502 | 0.5741 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0194 | 0.1894 | 0.2367 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.1474 | 0.1854 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0031 | 0.0073 | 0.099 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0428 | 0.4502 | 0.5741 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.0118 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0428 | 0.4502 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0118 | 0.0118 |
Brugia malayi | nuclear receptor NHR-67 | 0.0194 | 0.1894 | 0.1876 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0118 | 0.0041 |
Brugia malayi | nuclear receptor NHR-88 | 0.0194 | 0.1894 | 0.1876 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0428 | 0.4502 | 0.4489 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0428 | 0.4502 | 0.5736 |
Schistosoma mansoni | coup transcription factor | 0.0428 | 0.4502 | 0.5736 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0118 | 0.0118 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0428 | 0.4502 | 0.4489 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.2161 | 0.2143 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0263 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.07 | 0.07 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0428 | 0.4502 | 0.4489 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0031 | 0.0073 | 0.099 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0023 | 0.0295 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0118 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2336 | 0.2336 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1894 | 0.1894 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0263 | 0.0263 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0428 | 0.4502 | 0.5756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.448 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.