Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0511 | 0.2889 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0031 | 0.0511 | 0.0511 |
Schistosoma mansoni | protein kinase | 0.0053 | 0.1768 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0511 | 0.2889 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0511 | 0.2889 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0053 | 0.1768 | 0.1628 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0031 | 0.0511 | 0.0511 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0031 | 0.0511 | 0.0511 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0053 | 0.1768 | 0.1628 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0031 | 0.0511 | 0.2889 |
Entamoeba histolytica | p21-activated kinase | 0.0053 | 0.1768 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.0546 | 0.0277 |
Brugia malayi | Protein kinase domain | 0.0053 | 0.1768 | 0.1768 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1733 | 0.1733 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0053 | 0.1768 | 0.1628 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0032 | 0.0546 | 0.0045 |
Schistosoma mansoni | protein kinase | 0.0053 | 0.1768 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0053 | 0.1768 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0053 | 0.1768 | 0.1628 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0168 | 0.8232 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.1733 | 0.9803 |
Schistosoma mansoni | tyrosine kinase | 0.0031 | 0.0511 | 0.2889 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.0546 | 0.0277 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0053 | 0.1768 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0022 | 0 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.0053 | 0.1768 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0053 | 0.1768 | 1 |
Brugia malayi | WH1 domain containing protein | 0.0031 | 0.0511 | 0.0511 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0053 | 0.1768 | 0.1628 |
Schistosoma mansoni | protein kinase | 0.0032 | 0.0546 | 0.3086 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0031 | 0.0511 | 0.2889 |
Trichomonas vaginalis | STE family protein kinase | 0.0032 | 0.0546 | 0.3086 |
Schistosoma mansoni | protein kinase | 0.0031 | 0.0511 | 0.2889 |
Trichomonas vaginalis | STE family protein kinase | 0.0053 | 0.1768 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0199 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0053 | 0.1768 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.0546 | 0.0277 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0053 | 0.1768 | 0.1628 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0168 | 0.8232 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 36.5 uM | Cytotoxic activity against human PBMC assessed as reduction in cell viability | ChEMBL. | 22033460 |
IC50 (functional) | = 0.05 uM | Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 22033460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.