TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 336.471 | Formula: C22H28N2O
H donors: 1 H acceptors: 1 LogP: 3.64 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N[C@H](c1ccccc1)C)CCN1CCC(CC1)c1ccccc1
InChi: 1S/C22H28N2O/c1-18(19-8-4-2-5-9-19)23-22(25)14-17-24-15-12-21(13-16-24)20-10-6-3-7-11-20/h2-11,18,21H,12-17H2,1H3,(H,23,25)/t18-/m0/s1
InChiKey: ZCFATTWFYKFQGO-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prolylcarboxypeptidase (angiotensinase C)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Brugia malayi	Serine carboxypeptidase S28 family protein	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	ko:K01285 lysosomal Pro-X carboxypeptidase [EC3.4.16.2], putative	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	serine carboxypeptidase S28, putative	prolylcarboxypeptidase (angiotensinase C)	496 aa	414 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0597	0.0903
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.8651
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Plasmodium vivax	sugar transporter, putative	0.0015	0.0201	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Leishmania major	protein kinase, putative	0.0032	0.0597	0.8517
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0201	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Giardia lamblia	Thymus-specific serine protease precursor	0.0025	0.0427	0.7335
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.245
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0597	0.245
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0582	1
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0112	0.2436	1
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0827
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0701	0.106
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0827
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0597	0.0903
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2436	1
Schistosoma mansoni	glucose transport protein	0.0104	0.2253	0.9249
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Toxoplasma gondii	protein kinase, putative	0.0295	0.6612	1
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0112	0.2436	1
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0597	0.2648
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0597	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0201	0.5052
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0201	0.2874
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0597	0.0597
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.2583
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0597	0.245
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0552	0.2264
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2253	1
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.0427	0.7153
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0201	0.0305
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0827
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	General substrate transporter	0.009	0.1918	0.7871
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0201	0.6328
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0597	0.0597
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.8651
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.245
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0104	0.2253	0.9249
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0201	0.6328
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0201	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.2389
Onchocerca volvulus		0.0025	0.0427	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.027	0.386
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0827
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0827
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0112	0.2436	1
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.8651
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0656
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0201	0.0305
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0025	0.0427	0.1894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.1636
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Brugia malayi	Serine protease Z688.6 precursor	0.0025	0.0427	0.1752
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.2389
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0597	0.0597
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.8651
Plasmodium falciparum	hexose transporter	0.0104	0.2253	0.2253
Schistosoma mansoni	glucose transporter	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.1837
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0201	0.5052
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.8651
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0552	0.2264
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.0427	0.7153
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0827
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0827
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.6679
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.1636
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0025	0.0427	0.6092
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0827
Brugia malayi	Serine protease Z688.6 precursor	0.0025	0.0427	0.1752
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.9752
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.6849
Schistosoma mansoni	glucose transport protein	0.0104	0.2253	0.9249
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0427	0.1894
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.2389
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.245
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0025	0.0427	0.7153
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.2389
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Plasmodium falciparum	protein kinase 7	0.0295	0.6612	0.6612
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0025	0.0427	0.1752
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0827
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.5469
Loa Loa (eye worm)	sugar transporter	0.0015	0.0201	0.0827
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.0025	0.0427	0.6092
Schistosoma mansoni	glucose transport protein	0.0104	0.2253	0.9249
Mycobacterium ulcerans	sugar transporter	0.0015	0.0201	0.5052
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0427	0.1752
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1636
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0112	0.2436	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Brugia malayi	Sugar transporter family protein	0.0104	0.2253	0.9249
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0827
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.2253	0.9249
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0169	0.3724	0.3724
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0597	0.0597
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0701	0.0701
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0701	0.0701
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0597	0.245
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0025	0.0427	0.1894
Giardia lamblia	Serine peptidase, putative	0.0025	0.0427	0.7335
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0827
Echinococcus granulosus	General substrate transporter	0.009	0.1918	0.7871
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0827
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0597	0.0903
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0827
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.1769
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0827
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0169	0.3724	0.5632
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0427	0.1894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0201	0.0827
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0025	0.0427	0.1752
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium vivax	hexose transporter	0.0104	0.2253	0.2253
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0169	0.3724	0.3724
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0025	0.0427	0.6092
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0827
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.1636
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.1636
Leishmania major	hypothetical protein, conserved	0.0015	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.245
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0597	0.8517
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0827
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0201	0.5052
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.2253	0.3408
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2978
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0201	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2436	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0827
Schistosoma mansoni	hypothetical protein	0.0104	0.2253	0.9249
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0827
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0201	0.2874
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0318	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0443	1	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0582	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2436	1
Giardia lamblia	Sugar-proton symporter	0.0015	0.0201	0.346
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0201	0.2874
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0827
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.2389
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0025	0.0427	0.1894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1636
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	1
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.245
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0597	0.0597
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0025	0.0427	0.0646
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0201	0.2874
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0201	0.0201
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0025	0.0427	0.1752
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0201	0.0827
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Brugia malayi	Cam kinase protein 1	0.0032	0.0597	0.245
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.2389
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.2389
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0597	0.245
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0827
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0025	0.0427	0.1894
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0597	0.0597
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0827
Giardia lamblia	Hexose transporter	0.0015	0.0201	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.9249
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0827
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0827
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0597	0.245
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0827

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 80 nM	Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay	ChEMBL.	22079761

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1938513

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1597279