Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 2 (subtype EP2) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 1 (subtype EP1) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0453 | 0.221 | 0.2958 |
Brugia malayi | AMP-binding enzyme family protein | 0.0644 | 0.3957 | 0.3957 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.073 | 0.474 | 0.6325 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.073 | 0.474 | 0.6345 |
Mycobacterium ulcerans | thioesterase TesA | 0.0575 | 0.3319 | 0.4444 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0575 | 0.3319 | 0.4444 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.073 | 0.474 | 0.6345 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0495 | 0.2594 | 0.3472 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0687 | 0.4348 | 0.582 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0453 | 0.221 | 0.2918 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.073 | 0.474 | 0.6345 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.073 | 0.474 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0561 | 0.3197 | 0.4281 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0392 | 0.1648 | 0.2206 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0491 | 0.2553 | 0.3734 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.073 | 0.474 | 0.6325 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1243 | 0.9438 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1028 | 0.747 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0687 | 0.4348 | 0.5797 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1028 | 0.747 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0644 | 0.3957 | 0.3901 |
Loa Loa (eye worm) | hypothetical protein | 0.1156 | 0.864 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0687 | 0.4348 | 0.582 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0575 | 0.3319 | 0.4412 |
Mycobacterium ulcerans | polyketide synthase | 0.0687 | 0.4348 | 0.582 |
Mycobacterium ulcerans | thioesterase | 0.0575 | 0.3319 | 0.4444 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0279 | 0.0612 | 0.0819 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0552 | 0.3114 | 0.4169 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1028 | 0.747 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0669 | 0.4178 | 0.5594 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1572 | 0.0795 |
Onchocerca volvulus | 0.12 | 0.9046 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0687 | 0.4348 | 0.5797 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0669 | 0.4178 | 0.5594 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.073 | 0.474 | 0.6345 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0687 | 0.4348 | 0.582 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0687 | 0.4348 | 0.582 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0217 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0687 | 0.4348 | 0.582 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0447 | 0.2154 | 0.2592 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0687 | 0.4348 | 0.4348 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0552 | 0.3114 | 0.4136 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1028 | 0.747 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0453 | 0.221 | 0.2958 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.073 | 0.474 | 0.6345 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0217 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0644 | 0.3957 | 0.5297 |
Loa Loa (eye worm) | fatty acid synthase | 0.068 | 0.4288 | 0.4332 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0687 | 0.4348 | 0.582 |
Mycobacterium ulcerans | polyketide synthase | 0.073 | 0.474 | 0.6345 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0687 | 0.4348 | 0.582 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.073 | 0.474 | 0.6325 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0552 | 0.3114 | 0.4169 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0234 | 0.0205 | 0.0275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 1 10'4nM | Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 0.77 nM | Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 42 nM | Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Ki (binding) | = 49 nM | Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22119471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.