TDR Targets

Basic information

Technical information

TDR Targets ID: 1606399
Name: N-(1-pyrimidin-4-ylethylideneamino)-1,3-benzo thiazol-2-amine
MW: 269.325 | Formula: C13H11N5S
H donors: 1 H acceptors: 3 LogP: 3.16 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=N\Nc1nc2c(s1)cccc2)/c1ccncn1
InChi: 1S/C13H11N5S/c1-9(10-6-7-14-8-15-10)17-18-13-16-11-4-2-3-5-12(11)19-13/h2-8H,1H3,(H,16,18)/b17-9+
InChiKey: ZMEIUSLAHMLILY-RQZCQDPDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[1-(4-pyrimidinyl)ethylideneamino]-1,3-benzothiazol-2-amine
1,3-benzothiazol-2-yl-(1-pyrimidin-4-ylethylideneamino)amine
NSC693632
NCI60_033528
NCIChal_000042
NCIMech_000097

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0043	0.0658	0.0658
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Brugia malayi	putative neuropeptide receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	SWI:SNF matrix associated	0.0389	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.0189	0.0189
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0026	0.0189	0.0189
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.0189	0.0189
Schistosoma mansoni	fusion	0.0138	0.3225	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	amine GPCR	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0658	0.0658
Entamoeba histolytica	hypothetical protein	0.0043	0.0658	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0389	1	1
Brugia malayi	neuropeptide F receptor	0.0026	0.0189	0.0189
Brugia malayi	G protein-coupled receptor F59B2.13	0.0026	0.0189	0.0189
Brugia malayi	Serotonin receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus granulosus	serotonin receptor	0.0026	0.0189	0.0189
Trypanosoma cruzi	hypothetical protein, conserved	0.0138	0.3225	1
Leishmania major	hypothetical protein, conserved	0.0138	0.3225	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.003	0.0307	0.0307
Schistosoma mansoni	hypothetical protein	0.0205	0.5014	0.5014
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0307	0.0307
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	TRABID protein (C64 family)	0.0138	0.3225	0.3225
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0026	0.0189	0.0189
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0307	0.0307
Onchocerca volvulus		0.0138	0.3225	0.3095
Echinococcus multilocularis	neuropeptide receptor A26	0.0026	0.0189	0.0189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Echinococcus granulosus	geminin	0.0205	0.5014	0.5014
Schistosoma mansoni	neuropeptide f receptor 76f	0.0026	0.0189	0.0189
Echinococcus granulosus	fmrfamide receptor	0.0026	0.0189	0.0189
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0138	0.3225	0.3095
Echinococcus granulosus	sex peptide receptor	0.0026	0.0189	0.0189
Leishmania major	hypothetical protein, conserved	0.0138	0.3225	1
Schistosoma mansoni	opsin-like receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0026	0.0189	0.0189
Brugia malayi	brahma associated protein 60 kDa	0.0389	1	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0389	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.338	0.338
Brugia malayi	follicle stimulating hormone receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	allatostatin A receptor	0.0026	0.0189	0.0189
Leishmania major	hypothetical protein, conserved	0.0138	0.3225	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0389	1	1
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0389	1	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.3225	0.3225
Echinococcus granulosus	g-protein coupled receptor	0.0026	0.0189	0.0189
Leishmania major	hypothetical protein, conserved	0.0138	0.3225	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0138	0.3225	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.0189	0.0189
Leishmania major	hypothetical protein, conserved	0.0138	0.3225	1
Schistosoma mansoni	histamine h1 receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	dro:myosuppressin receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0389	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0026	0.0189	0.0189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0138	0.3225	0.3225
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0026	0.0189	0.0189
Plasmodium vivax	hypothetical protein, conserved	0.0389	1	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.0389	1	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	opsin-like receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	G protein-coupled receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	allatostatin A receptor	0.0026	0.0189	0.0189
Brugia malayi	Melatonin receptor type 1A	0.0026	0.0189	0.0189
Echinococcus multilocularis	somatostatin receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	zinc finger protein Ran binding	0.0138	0.3225	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0026	0.0189	0.0189
Brugia malayi	AKH receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptide receptor	0.0026	0.0189	0.0189
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0138	0.3225	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0658	0.0658
Trypanosoma cruzi	hypothetical protein, conserved	0.0138	0.3225	1
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.0189	0.0189
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0138	0.3225	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Leishmania major	hypothetical protein, conserved	0.003	0.0307	0.0952
Schistosoma mansoni	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0658	0.0658
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0043	0.0658	0.0658
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0138	0.3225	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Trypanosoma cruzi	hypothetical protein, conserved	0.0138	0.3225	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.338	0.338
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0189	0.0189
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Trypanosoma brucei	hypothetical protein, conserved	0.0138	0.3225	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0026	0.0189	0.0189
Entamoeba histolytica	hypothetical protein	0.0043	0.0658	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	zinc finger protein Ran binding	0.0138	0.3225	0.3225
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	7tm_1 domain containing protein	0.0026	0.0189	0.0189
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0138	0.3225	0.3225
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0189	0.0189
Entamoeba histolytica	hypothetical protein	0.0043	0.0658	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0307	0.0307
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Brugia malayi	RE15519p	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.002	0.0015	0.0015
Chlamydia trachomatis	SWIB complex protein	0.0389	1	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0138	0.3225	0.3225
Schistosoma mansoni	growth hormone secretagogue receptor	0.0026	0.0189	0.0189
Trypanosoma cruzi	WLM domain containing protein, putative	0.0138	0.3225	1
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0389	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0189	0.0189
Onchocerca volvulus		0.0138	0.3225	0.3095
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Brugia malayi	GnHR receptor homolog	0.0026	0.0189	0.0189
Echinococcus granulosus	7TM GPCR rhodopsin	0.0026	0.0189	0.0189
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.0189	0.0189
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0026	0.0189	0.0189
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0189	0.0189
Brugia malayi	Serotonin receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus granulosus	orexin receptor type 2	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptide receptor A26	0.0026	0.0189	0.0189
Brugia malayi	Dopamine receptor protein 2	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	brahma associated protein	0.0389	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	somatostatin receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	Zinc finger RanBP2 type	0.0138	0.3225	0.3225
Echinococcus multilocularis	g-protein coupled receptor	0.0026	0.0189	0.0189
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0307	0.0952
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0138	0.3225	0.3225
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	Dopamine receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0026	0.0189	0.0189
Brugia malayi	neuropeptide F receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.0189	0.0189
Schistosoma mansoni	myosin xvIII	0.0026	0.0189	0.0189
Entamoeba histolytica	hypothetical protein	0.0043	0.0658	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	brg-1 associated factor	0.0389	1	1
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0138	0.3225	0.3225
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	serotonin receptor	0.0026	0.0189	0.0189
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0138	0.3225	0.3225
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0026	0.0189	0.0189
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0389	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptide receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0138	0.3225	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0138	0.3225	0.3225
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0138	0.3225	0.3225
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0138	0.3225	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptide s receptor	0.0026	0.0189	0.0189
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0026	0.0189	0.0189
Brugia malayi	YY1-associated factor 2	0.0138	0.3225	0.3225
Loa Loa (eye worm)	hypothetical protein	0.003	0.0307	0.0307
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0026	0.0189	0.0189
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0138	0.3225	0.3225
Schistosoma mansoni	opsin-like receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0026	0.0189	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0389	1	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Chlamydia trachomatis	DNA topoisomerase I	0.0389	1	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0189	0.0189
Brugia malayi	larval opioid receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	SWI:SNF matrix associated	0.0389	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0138	0.3225	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0026	0.0189	0.0189
Brugia malayi	Dopamine receptor protein 1	0.0026	0.0189	0.0189
Onchocerca volvulus		0.0138	0.3225	0.3095
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0138	0.3225	0.3225
Schistosoma mansoni	hypothetical protein	0.0205	0.5014	0.5014
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0189	0.0189
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0026	0.0189	0.0189
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0026	0.0189	0.0189
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0189	0.0189
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0026	0.0189	0.0189
Echinococcus granulosus	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	ring and YY1 binding protein	0.0138	0.3225	0.3225
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0189	0.0189
Onchocerca volvulus		0.0138	0.3225	0.3095
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Toxoplasma gondii	ran binding protein	0.0138	0.3225	0.3225
Echinococcus multilocularis	neuropeptide s receptor	0.0026	0.0189	0.0189
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0389	1	1
Schistosoma mansoni	amine GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0026	0.0189	0.0189
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0307	0.0952
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0138	0.3225	0.3225
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0307	0.0307
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0138	0.3225	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	amine GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0026	0.0189	0.0189
Brugia malayi	sulfakinin receptor protein	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	adenoreceptor	0.0026	0.0189	0.0189
Echinococcus granulosus	ring and YY1 binding protein	0.0138	0.3225	0.3225
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	G protein coupled receptor 139	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	RNA binding protein	0.0138	0.3225	0.3225
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.0189	0.0189
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0026	0.0189	0.0189
Brugia malayi	MH2 domain containing protein	0.0144	0.338	0.338
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.0189	0.0189
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0307	0.0952
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0389	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0026	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0026	0.0189	0.0189
Echinococcus multilocularis	serotonin receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0389	1	1
Echinococcus multilocularis	sex peptide receptor	0.0026	0.0189	0.0189
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0138	0.3225	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0138	0.3225	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0026	0.0189	0.0189
Schistosoma mansoni	amine GPCR	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0026	0.0189	0.0189
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0389	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0026	0.0189	0.0189
Echinococcus multilocularis	SWI:SNF matrix associated	0.0389	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	amine GPCR	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0026	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Schistosoma mansoni	zinc finger protein	0.0138	0.3225	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0189
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0138	0.3225	0.3225
Echinococcus multilocularis	SWI:SNF matrix associated	0.0389	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0189	0.0189
Echinococcus multilocularis	geminin	0.0205	0.5014	0.5014
Brugia malayi	ORL1-like opioid receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0026	0.0189	0.0189
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.0189	0.0189
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.0189	0.0189
Brugia malayi	G-protein coupled receptor	0.0026	0.0189	0.0189
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.0189	0.0189
Brugia malayi	G-protein coupled receptor	0.0026	0.0189	0.0189
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0026	0.0189	0.0189
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0138	0.3225	1
Onchocerca volvulus		0.0389	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-7.172	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.421	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.412	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.252	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.207	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.152	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.088	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.857	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.451	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.025	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1988351

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1606399