Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0018 | 0.0019 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0515 | 0.2856 | 0.2839 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0515 | 0.2857 | 0.284 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0515 | 0.2856 | 0.5074 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.1304 | 0.9596 | 1 |
Brugia malayi | hypothetical protein | 0.0182 | 0.0018 | 0.0019 |
Echinococcus granulosus | geminin | 0.0205 | 0.0207 | 0.0207 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0231 | 0.0428 | 0.5 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1352 | 1 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1352 | 1 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0515 | 0.2857 | 0.284 |
Leishmania major | carboxylase, putative | 0.0515 | 0.2856 | 0.2839 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0207 | 0.0184 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0515 | 0.2856 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0515 | 0.2856 | 0.2839 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0978 | 0.6811 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0515 | 0.2856 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0515 | 0.2856 | 1 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0515 | 0.2856 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0515 | 0.2856 | 0.2839 |
Onchocerca volvulus | 0.0182 | 0.0018 | 0.5 | |
Trypanosoma brucei | unspecified product | 0.0338 | 0.135 | 0.1329 |
Schistosoma mansoni | pyruvate carboxylase | 0.0515 | 0.2856 | 0.2839 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.1304 | 0.9596 | 1 |
Toxoplasma gondii | pyruvate carboxylase | 0.0515 | 0.2856 | 0.2839 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0183 | 0.0024 | 0.0024 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1352 | 1 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0515 | 0.2856 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0207 | 0.0184 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0515 | 0.2856 | 0.2856 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0837 | 0.5604 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0515 | 0.2856 | 0.2856 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1352 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0515 | 0.2856 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1352 | 1 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0515 | 0.2856 | 0.5074 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0515 | 0.2856 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.0468 | 0.2451 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1352 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0207 | 0.0207 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0978 | 0.6811 | 0.5 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0183 | 0.0024 | 0.0024 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0515 | 0.2856 | 1 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0231 | 0.0428 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6513 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 7.3078 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | 7.9433 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.