Detailed information for compound 1610172

Basic information

Technical information
  • TDR Targets ID: 1610172
  • Name: [3,5-diacetyloxy-2-(acetyloxymethyl)-6-[(4-ox o-1,3-thiazol-2-yl)sulfanyl]oxan-4-yl] acetat e
  • MW: 463.479 | Formula: C17H21NO10S2
  • H donors: 0 H acceptors: 5 LogP: 0.88 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCC1OC(SC2=NC(=O)CS2)C(C(C1OC(=O)C)OC(=O)C)OC(=O)C
  • InChi: 1S/C17H21NO10S2/c1-7(19)24-5-11-13(25-8(2)20)14(26-9(3)21)15(27-10(4)22)16(28-11)30-17-18-12(23)6-29-17/h11,13-16H,5-6H2,1-4H3
  • InChiKey: VBCOZGGZAXMRCW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [3,5-diacetoxy-2-(acetoxymethyl)-6-(4-oxothiazol-2-yl)sulfanyl-tetrahydropyran-4-yl] acetate
  • acetic acid [3,5-diacetoxy-2-(acetoxymethyl)-6-[(4-oxo-2-thiazolyl)thio]-4-tetrahydropyranyl] ester
  • acetic acid [3,5-diacetoxy-2-(acetoxymethyl)-6-[(4-ketothiazol-2-yl)thio]tetrahydropyran-4-yl] ester
  • [3,5-diacetyloxy-2-(acetyloxymethyl)-6-[(4-oxo-1,3-thiazol-2-yl)sulfanyl]oxan-4-yl] ethanoate
  • NCI60_027953
  • NCI60_027954
  • NSC678082
  • NSC678083
  • 4-Oxo-4,5-dihydro-1,3-thiazol-2-yl 2,3,4,6-tetra-O-acetyl-1-thiohexopyranoside
  • AIDS-161215
  • AIDS161215

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.5836 0.5836
Brugia malayi Trypsin family protein 0.0155 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0531 0.254 0.254
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0246 0.1075 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.1284 0.6423 0.6423
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0403 0.1882 0.1882
Echinococcus granulosus glycoprotein Antigen 5 0.0155 0.0602 0.0146
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0128 0.0462 0.0462
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0462 0.0462
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0155 0.0602 0.0146
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0663 0.3224 0.3224
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0128 0.0462 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.3224 0.3224
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0374 0.1733 0.1733
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1978 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1978 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0663 0.3224 0.2895
Loa Loa (eye worm) phosphatidylinositol 3 0.1978 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Brugia malayi Trypsin family protein 0.0155 0.0602 0.0602
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.8509 0.8509
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1573 0.7914 0.7914
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0935 0.4626 0.4626
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0462 0.0462
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0374 0.1733 0.1332
Entamoeba histolytica protein kinase rad3, putative 0.0374 0.1733 0.1733
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0462 0.0462
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0462 0.0462
Schistosoma mansoni hypothetical protein 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1978 1 1
Plasmodium vivax hypothetical protein, conserved 0.0128 0.0462 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Onchocerca volvulus 0.0155 0.0602 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1068 0.531 0.531
Entamoeba histolytica hypothetical protein 0.0128 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0374 0.1733 0.1733
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0663 0.3224 0.2895
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1068 0.531 0.531
Trichomonas vaginalis PIKK family atypical protein kinase 0.1573 0.7914 0.7914
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0155 0.0602 0.0146
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0289 0.1295 0.0873
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0128 0.0462 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0128 0.0462 0.5
Toxoplasma gondii FATC domain-containing protein 0.0374 0.1733 0.1835
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0128 0.0462 0.0462
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1573 0.7914 0.7914
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0374 0.1733 0.1733
Trichomonas vaginalis PIKK family atypical protein kinase 0.1068 0.531 0.531
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0128 0.0462 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0374 0.1733 0.1733
Giardia lamblia GTOR 0.1978 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0128 0.0462 0.0462
Echinococcus multilocularis enteropeptidase 0.0155 0.0602 0.0146
Brugia malayi hypothetical protein 0.0155 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.5836 0.5836
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0462 0.0462
Entamoeba histolytica hypothetical protein 0.0128 0.0462 0.0462
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0155 0.0602 0.0146
Echinococcus multilocularis Mastin 0.0155 0.0602 0.0146
Onchocerca volvulus 0.0155 0.0602 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.5301 0.5301
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0246 0.1075 0.1075
Trichomonas vaginalis PIKK family atypical protein kinase 0.1182 0.5897 0.5897
Brugia malayi FAT domain containing protein 0.0289 0.1295 0.1295
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0155 0.0602 0.0146
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1575 0.7922 0.7822
Onchocerca volvulus 0.0155 0.0602 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0462 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Mycobacterium ulcerans hypothetical protein 0.0155 0.0602 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1978 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.1953 0.1953
Leishmania major phosphatidylinositol 3-kinase, putative 0.0663 0.3224 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.3224 0.3224
Trichomonas vaginalis PIKK family atypical protein kinase 0.1182 0.5897 0.5897
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0663 0.3224 0.3224
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1978 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Entamoeba histolytica hypothetical protein 0.0374 0.1733 0.1733
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1573 0.7914 0.7914
Echinococcus granulosus serine protein kinase ATM 0.0374 0.1733 0.1332
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0128 0.0462 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0663 0.3224 0.3224
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1978 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0374 0.1733 0.1332
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.0462
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0663 0.3224 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.3224 0.3224
Mycobacterium leprae conserved hypothetical protein 0.0128 0.0462 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Echinococcus granulosus Mastin 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.3224 0.3224
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0289 0.1295 0.0873
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.5301 0.5301
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Trichomonas vaginalis PIKK family atypical protein kinase 0.1182 0.5897 0.5897
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0128 0.0462 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0128 0.0462 0.0462
Brugia malayi Trypsin-like protease protein 5 0.0155 0.0602 0.0602
Echinococcus granulosus enteropeptidase 0.0155 0.0602 0.0146
Schistosoma mansoni hypothetical protein 0.0155 0.0602 0.0146
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0663 0.3224 0.2895
Toxoplasma gondii target of rapamycin (TOR), putative 0.1471 0.7387 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0462 0.0462
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0374 0.1733 0.1332
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0128 0.0462 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1978 1 1
Plasmodium vivax hypothetical protein 0.0128 0.0462 0.5
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.1733 0.1733
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1075 0.1075
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0462 0.0462
Echinococcus granulosus transmembrane protease serine 3 0.0155 0.0602 0.0146
Loa Loa (eye worm) hypothetical protein 0.0417 0.1953 0.1953
Trypanosoma cruzi target of rapamycin kinase 3 0.1575 0.7922 0.7822
Trichomonas vaginalis PIKK family atypical protein kinase 0.1978 1 1
Loa Loa (eye worm) hypothetical protein 0.0289 0.1295 0.1295
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0128 0.0462 0.0462
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1978 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0417 0.1953 0.2153
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0374 0.1733 0.1332
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0128 0.0462 0.0462
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0462 0.0462
Onchocerca volvulus 0.0155 0.0602 1
Loa Loa (eye worm) trypsin family protein 0.0155 0.0602 0.0602
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0128 0.0462 0.5
Loa Loa (eye worm) phosphatidylinositol kinase 0.0128 0.0462 0.0462
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1978 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1978 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0128 0.0462 0.0462
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.0462
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1575 0.7922 0.7922
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.1295 0.1295
Schistosoma mansoni fkbp-rapamycin associated protein 0.0374 0.1733 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Trichomonas vaginalis PIKK family atypical protein kinase 0.1326 0.6643 0.6643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0462 0.0462
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0374 0.1733 0.1332
Onchocerca volvulus 0.0155 0.0602 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0128 0.0462 0.0462
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.0462
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Echinococcus multilocularis glycoprotein Antigen 5 0.0155 0.0602 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1471 0.7387 0.7387
Echinococcus multilocularis serine protein kinase ATM 0.0374 0.1733 0.1332
Onchocerca volvulus 0.0155 0.0602 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0155 0.0602 0.0146
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.3224 0.3224
Entamoeba histolytica hypothetical protein 0.0128 0.0462 0.0462
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0663 0.3224 0.2895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0374 0.1733 0.1733
Entamoeba histolytica hypothetical protein 0.0128 0.0462 0.0462
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.1733 0.1733
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.5301 0.5301
Mycobacterium tuberculosis Conserved hypothetical protein 0.0128 0.0462 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1978 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0128 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1573 0.7914 0.7914
Trichomonas vaginalis PIKK family atypical protein kinase 0.1068 0.531 0.531
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0128 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0155 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0128 0.0462 0.0462
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0821 0.4039 0.4039
Echinococcus multilocularis transmembrane protease serine 3 0.0155 0.0602 0.0146
Brugia malayi Trypsin family protein 0.0155 0.0602 0.0602
Schistosoma mansoni hypothetical protein 0.0289 0.1295 0.0873
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0663 0.3224 0.3224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.1733 0.1733
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0155 0.0602 0.0602
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.0462 0.0462
Brugia malayi Trypsin family protein 0.0155 0.0602 0.0602
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1978 1 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.1075 0.1075
Schistosoma mansoni cercarial elastase (S01 family) 0.0155 0.0602 0.0146
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0128 0.0462 0.0462
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1978 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0663 0.3224 0.2895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0462 0.0462

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.631 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.574 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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