Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RAB, member of RAS oncogene family-like 5 | 0.008 | 0.0375 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0375 | 0.0348 |
Schistosoma mansoni | protein phosphatases pp1 regulatory subunit | 0.0015 | 0.0031 | 0.0669 |
Schistosoma mansoni | calpain 4 6 7 invertebrate | 0.0015 | 0.0031 | 0.0669 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0375 | 0.8199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.008 | 0.0375 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.008 | 0.0375 | 1 |
Onchocerca volvulus | 0.0018 | 0.0044 | 0.04 | |
Echinococcus granulosus | rab protein 3 | 0.008 | 0.0375 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0375 | 0.0348 |
Echinococcus granulosus | GTP binding protein Parf | 0.008 | 0.0375 | 0.036 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.1885 | 0.9932 | 1 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0018 | 0.0044 | 0.04 |
Echinococcus multilocularis | cell polarity protein leucine rich repeat | 0.0018 | 0.0044 | 0.0014 |
Onchocerca volvulus | Peroxidasin homolog | 0.0018 | 0.0044 | 0.04 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 0.0039 | 0.0832 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0031 | 0.0669 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.008 | 0.0375 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.1885 | 0.9932 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0044 | 0.04 |
Brugia malayi | hypothetical protein | 0.008 | 0.0375 | 0.0348 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0375 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.0375 | 1 |
Echinococcus multilocularis | ras-related protein rab-5 | 0.008 | 0.0375 | 0.0348 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.0458 | 1 |
Schistosoma mansoni | protein phosphatases pp1 regulatory subunit | 0.0015 | 0.0031 | 0.0669 |
Brugia malayi | Ras-related protein ypt4 | 0.008 | 0.0375 | 0.0348 |
Echinococcus multilocularis | leucine rich repeat containing protein 23 | 0.0018 | 0.0044 | 0.0014 |
Echinococcus multilocularis | GTP binding protein Parf | 0.008 | 0.0375 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0031 | 0.0669 |
Echinococcus granulosus | nischarin | 0.0015 | 0.0031 | 0.0015 |
Brugia malayi | Leucine Rich Repeat family protein | 0.0018 | 0.0044 | 0.0014 |
Trichomonas vaginalis | leucine-rich repeat-containing protein, putative | 0.0018 | 0.0044 | 0.04 |
Onchocerca volvulus | 0.008 | 0.0375 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.008 | 0.0375 | 1 |
Echinococcus granulosus | leucine rich repeat containing protein 23 | 0.0018 | 0.0044 | 0.0029 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.008 | 0.0375 | 1 |
Trichomonas vaginalis | leucine-rich repeat-containing protein, putative | 0.0018 | 0.0044 | 0.04 |
Onchocerca volvulus | 0.0018 | 0.0044 | 0.04 | |
Trichomonas vaginalis | toll, putative | 0.0018 | 0.0044 | 0.04 |
Trypanosoma cruzi | protein phosphatase 1, regulatory subunit, putative | 0.0018 | 0.0044 | 0.04 |
Echinococcus multilocularis | rab protein 3 | 0.008 | 0.0375 | 0.0348 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.0375 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.008 | 0.0375 | 1 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0442 | 0.2291 | 0.2282 |
Entamoeba histolytica | leucine rich repeat and phosphatase domain containing protein | 0.0015 | 0.0031 | 0.0617 |
Onchocerca volvulus | 0.0018 | 0.0044 | 0.04 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.008 | 0.0375 | 1 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.008 | 0.0375 | 1 |
Echinococcus multilocularis | leucine rich repeat containing protein 57 | 0.0018 | 0.0044 | 0.0014 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0099 | 0.0472 | 0.0446 |
Plasmodium vivax | protein phosphatases PP1 regulatory subunit sds22, putative | 0.0018 | 0.0044 | 0.04 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0375 | 1 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.008 | 0.0375 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1885 | 0.9932 | 1 |
Trichomonas vaginalis | TKL family protein kinase | 0.0017 | 0.0039 | 0.0229 |
Trichomonas vaginalis | protein phosphatases pp1 regulatory subunit, putative | 0.0018 | 0.0044 | 0.04 |
Brugia malayi | Protein kinase domain containing protein | 0.0442 | 0.2291 | 0.2282 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.008 | 0.0375 | 1 |
Echinococcus granulosus | mitogen-activated protein kinase kinase kinase 9 | 0.0099 | 0.0472 | 0.0457 |
Brugia malayi | Leucine Rich Repeat family protein | 0.0018 | 0.0044 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0375 | 0.0348 |
Entamoeba histolytica | leucine-rich repeat containing protein | 0.0015 | 0.0031 | 0.0617 |
Giardia lamblia | Leucine-rich repeat protein | 0.0018 | 0.0044 | 1 |
Toxoplasma gondii | leucine-rich repeat protein LRR1 | 0.0018 | 0.0044 | 1 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.008 | 0.0375 | 1 |
Schistosoma mansoni | dynein light chain | 0.0015 | 0.0031 | 0.0669 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.