Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0898 | 0.1256 | 0.1256 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1556 | 0.2199 | 0.2199 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1556 | 0.2199 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3996 | 0.5699 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3996 | 0.5699 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3996 | 0.5699 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1556 | 0.2199 | 0.3859 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.0125 | 0.0125 |
Brugia malayi | Choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Brugia malayi | Choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.0125 | 0.0125 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3996 | 0.5699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.0125 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.6994 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.0125 | 0.0125 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.0125 | 0.5 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1556 | 0.2199 | 0.2124 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3996 | 0.5699 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.0125 | 0.0219 |
Echinococcus granulosus | choline O acetyltransferase | 0.0898 | 0.1256 | 0.2203 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.0125 | 0.0125 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1556 | 0.2199 | 0.2199 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.038 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0267 | 0.0351 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0898 | 0.1256 | 0.1256 |
Onchocerca volvulus | 0.0109 | 0.0125 | 0.0993 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1556 | 0.2199 | 0.2124 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.0125 | 0.0993 |
Schistosoma mansoni | choline o-acyltransferase | 0.0898 | 0.1256 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0898 | 0.1256 | 0.1256 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1556 | 0.2199 | 0.3859 |
Schistosoma mansoni | choline o-acyltransferase | 0.0898 | 0.1256 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0898 | 0.1256 | 0.2203 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.0125 | 0.0993 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.12 nM | Concentration required to inhibit 50% of radioligand binding ([3H]-WIN 35428) to the dopamine (DA) transporter in rat | ChEMBL. | 8071935 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.