Detailed information for compound 1617405

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.56 | Formula: C19H31N7O2S
  • H donors: 2 H acceptors: 4 LogP: 1.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCCNc1ccc(cn1)S(=O)(=O)Nc1c(C)nn(c1C)C
  • InChi: 1S/C19H31N7O2S/c1-15-19(16(2)25(4)22-15)23-29(27,28)17-6-7-18(21-14-17)20-8-5-9-26-12-10-24(3)11-13-26/h6-7,14,23H,5,8-13H2,1-4H3,(H,20,21)
  • InChiKey: VCBSTZQLEZNXPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens N-myristoyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania major N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Trichomonas vaginalis N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma cruzi N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Neospora caninum hypothetical protein Get druggable targets OG5_127597 All targets in OG5_127597
Theileria parva N-myristoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium berghei glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Giardia lamblia CDC72 Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma congolense N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium knowlesi glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Get druggable targets OG5_127597 All targets in OG5_127597
Schistosoma mansoni N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium yoelii N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma cruzi N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Babesia bovis myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain containing protein Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania braziliensis N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Schistosoma japonicum ko:K00671 glycylpeptide N-tetradecanoyltransferase [EC2.3.1.97], putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Cryptosporidium hominis N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Loa Loa (eye worm) N-myristoyltransferase 2 Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei gambiense N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania infantum N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania mexicana N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Brugia malayi N-myristoyltransferase 2 Get druggable targets OG5_127597 All targets in OG5_127597
Cryptosporidium parvum N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Get druggable targets OG5_127597 All targets in OG5_127597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.0846 0.1421
Brugia malayi N-myristoyltransferase 2 0.0216 0.5956 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0846 0.1046
Brugia malayi Protein kinase domain containing protein 0.0009 0.0005 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0846 0.1046
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Plasmodium falciparum thioredoxin reductase 0.005 0.1182 0.1635
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 1
Onchocerca volvulus 0.0038 0.0846 0.6734
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0249 0.0418
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0846 0.0921
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.3011 0.4262
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0216 0.5956 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0846 0.0921
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0846 0.3199
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.1182 0.1182
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0009 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0009 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0009 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0846 0.1046
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Onchocerca volvulus 0.0038 0.0846 0.6734
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.2116 0.327
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0009 0.0005 0.0005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0249 0.0249
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0846 0.1046
Schistosoma mansoni tyrosine kinase 0.0009 0.0005 0.0008
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0009 0.0005 0.0005
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.3011 0.4262
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0846 0.1046
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.1254 0.2105
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Loa Loa (eye worm) SRC-1 0.0009 0.0005 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0846 0.0991
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0568 0.0558
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0009 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0038 0.0846 0.0921
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0216 0.5956 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0008
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0216 0.5956 0.5956
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0118 0.0198
Echinococcus granulosus tyrosine protein kinase Lyn 0.0009 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0038 0.0846 0.1046
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.2116 0.2116
Brugia malayi SRC-1 0.0009 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0846 0.1421
Toxoplasma gondii ABC1 family protein 0.0038 0.0846 0.3199
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0846 0.1421
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0009 0.0005 0.0005
Loa Loa (eye worm) beta-lactamase 0.0038 0.0846 0.1421
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.2116 0.5514
Brugia malayi Protein kinase domain containing protein 0.0009 0.0005 0.0008
Loa Loa (eye worm) TK/ABL protein kinase 0.0009 0.0005 0.0008
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.1302 0.1302
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0846 0.1421
Onchocerca volvulus 0.0052 0.1254 1
Trypanosoma cruzi N-myristoyl transferase, putative 0.0216 0.5956 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0846 0.0921
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0846 0.0921
Trichomonas vaginalis N-myristoyl transferase, putative 0.0142 0.3829 0.6273
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0009 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0009 0.0005 0.0008
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.1302 0.1625
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0009 0.0005 0.0008
Mycobacterium ulcerans hypothetical protein 0.0038 0.0846 0.3199
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0846 0.1046
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0846 0.0921
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.2116 1
Brugia malayi SH2 domain containing protein 0.0009 0.0005 0.0008
Brugia malayi beta-lactamase 0.0038 0.0846 0.1421
Echinococcus multilocularis tyrosine protein kinase Srms 0.0009 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Echinococcus multilocularis tyrosine kinase 0.0009 0.0005 0.0005
Trypanosoma brucei trypanothione reductase 0.005 0.1182 0.1635
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0846 0.0921
Echinococcus multilocularis tyrosine protein kinase Abl 0.0009 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Trichomonas vaginalis esterase, putative 0.0038 0.0846 0.1046
Mycobacterium ulcerans beta-lactamase 0.0038 0.0846 0.3199
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 0.327
Brugia malayi Tyrosine-protein kinase abl-1 0.0009 0.0005 0.0008
Echinococcus granulosus tyrosine protein kinase ABL1 0.0009 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Trypanosoma brucei N-myristoyl transferase, putative 0.0216 0.5956 1
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.1302 0.1302
Brugia malayi beta-lactamase family protein 0.0038 0.0846 0.1421
Mycobacterium tuberculosis Probable reductase 0.0113 0.3011 0.4262
Schistosoma mansoni tyrosine kinase 0.0009 0.0005 0.0008
Onchocerca volvulus 0.0038 0.0846 0.6734
Brugia malayi Protein kinase domain containing protein 0.0009 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.1254 0.2105
Echinococcus multilocularis c src tyrosine kinase 0.0009 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0038 0.0846 0.0921
Echinococcus granulosus tyrosine kinase 0.0009 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.0028 0.0568 0.1708
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0846 0.1421
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.2116 0.2116
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0005 0.0005
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0568 0.0558
Brugia malayi glutathione reductase 0.005 0.1182 0.1985
Brugia malayi beta-lactamase family protein 0.0038 0.0846 0.1421
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0009 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 1
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Brugia malayi protein-tyrosine kinase 0.0009 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0846 0.1421
Mycobacterium leprae Probable lipase LipE 0.0038 0.0846 0.0991
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0846 0.0846
Loa Loa (eye worm) hypothetical protein 0.0038 0.0846 0.1421
Loa Loa (eye worm) TK protein kinase 0.0009 0.0005 0.0008
Mycobacterium tuberculosis Conserved protein 0.0038 0.0846 0.0921
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.3011 0.4262
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.6729 1
Echinococcus granulosus tyrosine kinase 0.0009 0.0005 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.1182 0.1182
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.3374 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0009 0.0005 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.3374 0.4823
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.1182 0.1635
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.2116 0.3552
Plasmodium vivax glutathione reductase, putative 0.005 0.1182 0.1635
Echinococcus granulosus tyrosine protein kinase shark 0.0009 0.0005 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.3359 0.5639
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 1
Schistosoma mansoni tyrosine kinase 0.0009 0.0005 0.0008
Toxoplasma gondii thioredoxin reductase 0.005 0.1182 0.4999
Brugia malayi MH2 domain containing protein 0.0126 0.3359 0.5639
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 1
Leishmania major trypanothione reductase 0.005 0.1182 0.1635
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0249 0.0249
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.1182 0.144
Plasmodium vivax thioredoxin reductase, putative 0.005 0.1182 0.1635
Plasmodium falciparum glutathione reductase 0.005 0.1182 0.1635
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0216 0.5956 0.5956
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0118 0.0198
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0009 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Src64B 0.0009 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0009 0.0005 0.0008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0249 0.0418
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0846 0.1046
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0009 0.0005 0.0008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.3011 0.8705
Echinococcus granulosus tyrosine protein kinase Srms 0.0009 0.0005 0.0005
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.1302 0.2616
Brugia malayi hypothetical protein 0.0009 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0846 0.1421
Trypanosoma cruzi N-myristoyl transferase, putative 0.0216 0.5956 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.3011 0.4262
Echinococcus multilocularis tyrosine protein kinase shark 0.0009 0.0005 0.0005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.3374 0.4823
Schistosoma mansoni tyrosine kinase 0.0009 0.0005 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.3359 0.5639
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0846 0.3199
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0009 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0005 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.1302 0.1625
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0846 0.1046
Mycobacterium ulcerans lipase LipD 0.0038 0.0846 0.3199
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.3011 0.4262
Schistosoma mansoni tyrosine kinase 0.0009 0.0005 0.0008
Brugia malayi Thioredoxin reductase 0.005 0.1182 0.1985
Echinococcus granulosus tyrosine protein kinase Blk 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0082 0.2116 0.3552
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.2116 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.3374 0.4823
Loa Loa (eye worm) hypothetical protein 0.0038 0.0846 0.1421
Loa Loa (eye worm) N-myristoyltransferase 2 0.0216 0.5956 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0846 0.1046
Trichomonas vaginalis N-myristoyl transferase, putative 0.0216 0.5956 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.2116 1
Brugia malayi Probable ClpP-like protease 0.0082 0.2116 0.3552
Loa Loa (eye worm) thioredoxin reductase 0.005 0.1182 0.1985
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0846 0.0846
Echinococcus granulosus c src tyrosine kinase 0.0009 0.0005 0.0005
Leishmania major N-myristoyl transferase, putative 0.0216 0.5956 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0846 0.0921
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0568 0.1708
Echinococcus multilocularis tyrosine protein kinase Blk 0.0009 0.0005 0.0005
Brugia malayi SH2 domain containing protein 0.0009 0.0005 0.0008
Schistosoma mansoni N-myristoyltransferase 0.0216 0.5956 1
Loa Loa (eye worm) glutathione reductase 0.005 0.1182 0.1985
Schistosoma mansoni tyrosine kinase 0.0009 0.0005 0.0008
Giardia lamblia CDC72 0.0216 0.5956 1
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0216 0.5956 1
Trypanosoma brucei N-myristoyltransferase 0.0216 0.5956 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0846 0.1421
Echinococcus granulosus tyrosine protein kinase Src42A 0.0009 0.0005 0.0005

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.4 uM Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior substrate addition measured after 50 mins by streptavidin-coated scintillation proximity assay ChEMBL. 22148754

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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