Detailed information for compound 1618327

Basic information

Technical information
  • TDR Targets ID: 1618327
  • Name: 1-chloro-2,7-dimethylphenothiazin-3-one
  • MW: 275.753 | Formula: C14H10ClNOS
  • H donors: 0 H acceptors: 1 LogP: 3.6 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)sc1c(n2)c(Cl)c(c(=O)c1)C
  • InChi: 1S/C14H10ClNOS/c1-7-3-4-9-11(5-7)18-12-6-10(17)8(2)13(15)14(12)16-9/h3-6H,1-2H3
  • InChiKey: JZMVJSFLFSCAEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-chloro-2,7-dimethyl-phenothiazin-3-one
  • 1-chloro-2,7-dimethyl-3-phenothiazinone
  • NSC641157
  • NCI60_013818
  • AIDS-051022
  • AIDS051022
  • 1-Chloro-2,7-dimethyl-phenothiazone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.043 0.0045
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0566 0.2324
Schistosoma mansoni hypothetical protein 0.0017 0.0416 0.0538
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0116 0.007
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0706 0.0408
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0706 0.0332
Echinococcus granulosus tyrosine kinase 0.0067 0.2787 0.388
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0116 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.1254 0.1039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0116 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0116 0.0052
Schistosoma mansoni tyrosine kinase 0.0074 0.3128 0.4768
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0023 0.0706 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0116 0.0052
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0159 0.7188 1
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0023 0.0706 0.0009
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0159 0.7188 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.1254 0.1039
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0322 0.0348
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.211 0.2932
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1326 0.1812
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0706 0.0332
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0322 0.0378
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.07 0.1945
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0706 0.4425
Loa Loa (eye worm) hypothetical protein 0.0017 0.043 0.0503
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0566 0.1654
Onchocerca volvulus 0.0034 0.1254 0.6381
Schistosoma mansoni hypothetical protein 0.0036 0.1326 0.1957
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0322 0.0392
Echinococcus multilocularis tyrosine protein kinase Srms 0.0067 0.2787 0.388
Echinococcus granulosus tyrosine protein kinase Blk 0.0067 0.2787 0.388
Toxoplasma gondii exonuclease III APE 0.002 0.0566 0.3008
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0706 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0116 0.0083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0116 0.007
Loa Loa (eye worm) hypothetical protein 0.0034 0.1254 0.1684
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0116 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0416 0.0482
Entamoeba histolytica protein kinase, putative 0.0059 0.2437 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0182
Schistosoma mansoni tyrosine kinase 0.0009 0.0079 0.0014
Brugia malayi beta-lactamase family protein 0.0034 0.1254 0.171
Loa Loa (eye worm) hypothetical protein 0.0023 0.07 0.089
Loa Loa (eye worm) hypothetical protein 0.0034 0.1254 0.1684
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0116 0.0083
Loa Loa (eye worm) hypothetical protein 0.0036 0.1326 0.1786
Mycobacterium ulcerans hypothetical protein 0.0159 0.7188 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Schistosoma mansoni tyrosine kinase 0.0074 0.3128 0.4768
Brugia malayi steroid hormone receptor 0.001 0.0116 0.0083
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0566 0.4944
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0116 0.0052
Schistosoma mansoni nuclear hormone receptor 0.001 0.0116 0.007
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0012 0.0206 0.0182
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0322 0.0348
Brugia malayi AMP-binding enzyme family protein 0.0023 0.07 0.0919
Schistosoma mansoni egf-like domain protein 0.0012 0.0206 0.0211
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0116 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0116 0.0083
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0025 0.0796 0.1055
Loa Loa (eye worm) hypothetical protein 0.0023 0.07 0.089
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0706 0.0898
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.07 0.04
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0706 0.0408
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.042 0.0518
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0116 0.0052
Echinococcus multilocularis muscleblind protein 1 0.0157 0.7057 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.1254 0.0903
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0322 0.0348
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0566 0.0727
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.1254 0.1039
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.042 0.0545
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0116 0.0083
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0116 0.0052
Echinococcus granulosus Aminotransferase class III 0.0023 0.0706 0.0898
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0116 0.0083
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0706 0.0408
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.07 0.04
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0566 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0116 0.0052
Echinococcus multilocularis tyrosine protein kinase Blk 0.0067 0.2787 0.388
Loa Loa (eye worm) hypothetical protein 0.0017 0.043 0.0503
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0012 0.0221 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0116 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0034 0.1254 1
Echinococcus granulosus GPCR family 2 0.0017 0.0416 0.0482
Echinococcus granulosus tyrosine protein kinase Src42A 0.0064 0.2689 0.374
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.07 0.04
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0116 0.0052
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0706 0.0898
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0566 0.0698
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0116 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0023 0.07 0.0919
Loa Loa (eye worm) SRC-1 0.0074 0.3128 0.4369
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.043 0.0503
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0074 0.3128 0.4369
Entamoeba histolytica hypothetical protein 0.0038 0.142 0.5826
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0025 0.0796 0.1027
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0706 0.0408
Onchocerca volvulus 0.0048 0.1921 1
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.1254 0.1039
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0116 0.0197
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.07 0.04
Schistosoma mansoni adapter molecule crk 0.0015 0.0322 0.0392
Schistosoma mansoni hypothetical protein 0.0038 0.142 0.2104
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.1254 0.0903
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.07 0.2873
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0706 0.0408
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.1254 0.1846
Brugia malayi Protein kinase domain containing protein 0.0009 0.0079 0.0031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.1254 0.122
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.1254 0.1684
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0566 0.0202
Schistosoma mansoni hypothetical protein 0.0017 0.0416 0.0538
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.027 0.0305
Schistosoma mansoni nck2/grb4 0.0015 0.0322 0.0392
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0067 0.2787 0.388
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.1254 0.0903
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0074 0.3128 0.4369
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0116 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0116 0.0083
Brugia malayi SRC-1 0.0074 0.3128 0.4386
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Brugia malayi Protein kinase domain containing protein 0.0009 0.0079 0.0031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.07 0.04
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0116 0.0052
Brugia malayi ecdysteroid receptor 0.001 0.0116 0.0083
Brugia malayi Protein kinase domain containing protein 0.0009 0.0079 0.0031
Loa Loa (eye worm) TK protein kinase 0.0059 0.2437 0.3379
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.211 0.291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0116 0.0052
Echinococcus granulosus tyrosine protein kinase Lyn 0.0074 0.3146 0.4396
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.1254 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.07 0.1945
Schistosoma mansoni tyrosine kinase 0.0009 0.0079 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.142 0.1921
Brugia malayi Fibulin-1 precursor 0.0013 0.027 0.0305
Echinococcus granulosus FTZ F1 alpha 0.001 0.0116 0.0052
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.042 0.0488
Brugia malayi beta-lactamase 0.0034 0.1254 0.171
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0706 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0416 0.0512
Echinococcus multilocularis tyrosine protein kinase HCK 0.0059 0.2437 0.3379
Onchocerca volvulus Arrow homolog 0.0025 0.0796 0.3891
Brugia malayi nuclear hormone receptor 0.001 0.0116 0.0083
Brugia malayi nuclear receptor NHR-88 0.001 0.0116 0.0083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0116 0.0052
Echinococcus multilocularis Tolloid protein 1 0.0012 0.0206 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0116 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0182
Mycobacterium leprae conserved hypothetical protein 0.0034 0.1254 0.0854
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0706 0.0898
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.07 0.0326
Mycobacterium ulcerans hypothetical protein 0.0023 0.07 0.04
Leishmania major hypothetical protein, conserved 0.0034 0.1254 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0074 0.3128 0.4369
Echinococcus granulosus laminin 0.0013 0.027 0.0274
Echinococcus granulosus tyrosine protein kinase Fyn 0.0074 0.3128 0.4369
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.6483 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0116 0.0083
Brugia malayi Calcium binding EGF domain containing protein 0.0048 0.1921 0.2663
Onchocerca volvulus 0.0034 0.1254 0.6381
Schistosoma mansoni coup transcription factor 0.001 0.0116 0.007
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0322 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0116 0.0083
Mycobacterium tuberculosis Probable aminotransferase 0.0159 0.7188 0.7075
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0706 0.0991
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0416 0.0482
Echinococcus granulosus tyrosine protein kinase Src64B 0.0074 0.3128 0.4369
Brugia malayi Protein kinase domain containing protein 0.0009 0.0079 0.0031
Loa Loa (eye worm) TK protein kinase 0.0067 0.2787 0.388
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0116 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0116 0.007
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0012 0.0206 0.0211
Brugia malayi Protein kinase domain containing protein 0.0009 0.0079 0.0031
Loa Loa (eye worm) hypothetical protein 0.0157 0.7057 1
Brugia malayi G2F domain containing protein 0.001 0.0122 0.0092
Entamoeba histolytica hypothetical protein 0.0038 0.142 0.5826
Schistosoma mansoni thyroid hormone receptor 0.001 0.0116 0.007
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.07 0.1945
Loa Loa (eye worm) hypothetical protein 0.0034 0.1254 0.1684
Brugia malayi Protein kinase domain containing protein 0.0144 0.6483 0.918
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0706 0.0332
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0116 0.007
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0416 0.0512
Brugia malayi beta-lactamase family protein 0.0034 0.1254 0.171
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0706 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.1254 0.0903
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0116 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0116 0.007
Onchocerca volvulus 0.001 0.0116 0.0197
Trichomonas vaginalis esterase, putative 0.0034 0.1254 0.1039
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.07 0.04
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0706 0.3345
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0061
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0159 0.7188 1
Toxoplasma gondii ABC1 family protein 0.0034 0.1254 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1254 0.1684
Loa Loa (eye worm) hypothetical protein 0.0034 0.1254 0.1684
Loa Loa (eye worm) beta-lactamase 0.0034 0.1254 0.1684
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0116 0.0052
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0116 0.0052
Echinococcus granulosus tyrosine protein kinase Fyn 0.0074 0.3128 0.4369
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.1254 0.0903
Echinococcus granulosus tyrosine protein kinase Src42A 0.0074 0.3128 0.4369
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0064 0.2689 0.374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0116 0.0052
Schistosoma mansoni hypothetical protein 0.0017 0.0416 0.0538
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.1254 0.122
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0116 0.0197
Echinococcus granulosus muscleblind protein 0.0157 0.7057 1
Schistosoma mansoni hypothetical protein 0.0017 0.0416 0.0538
Echinococcus multilocularis fibrillin 1 0.0013 0.027 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0116 0.0083
Echinococcus multilocularis GPCR, family 2 0.0017 0.0416 0.0482
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.07 0.2873
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.042 0.0488
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.1254 0.171
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.211 0.2932
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.1254 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0059 0.2437 0.3379
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.07 0.04
Loa Loa (eye worm) hypothetical protein 0.0017 0.043 0.0503
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.142 0.1921
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.3128 0.4369
Mycobacterium ulcerans hypothetical protein 0.0034 0.1254 0.122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0416 0.0482
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0566 0.0698
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0116 0.0083
Echinococcus multilocularis laminin 0.0013 0.027 0.0274
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0074 0.3128 0.4369
Loa Loa (eye worm) hypothetical protein 0.0157 0.7057 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.07 0.089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0116 0.007
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0322 0.0378
Schistosoma mansoni ap endonuclease 0.002 0.0566 0.0773
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.1254 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0074 0.3128 0.4369
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.1254 0.0903
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0116 0.0197
Loa Loa (eye worm) hypothetical protein 0.0038 0.1431 0.1937
Loa Loa (eye worm) hypothetical protein 0.0052 0.211 0.291
Echinococcus multilocularis muscleblind protein 0.0157 0.7057 1
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0706 0.0898
Onchocerca volvulus 0.0034 0.1254 0.6381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0116 0.0052
Loa Loa (eye worm) hypothetical protein 0.0034 0.1254 0.1684
Loa Loa (eye worm) hypothetical protein 0.0012 0.0206 0.0182
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0159 0.7188 0.7075
Echinococcus granulosus NCK adaptor protein 0.0015 0.0322 0.0348
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0116 0.0052
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0048 0.1921 0.264
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0144 0.6483 0.9177
Brugia malayi AMP-binding enzyme family protein 0.0023 0.07 0.0919
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.1254 0.1684
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0566 0.0187
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0706 0.0332
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0074 0.3128 0.4369
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0116 0.007
Brugia malayi hypothetical protein 0.0038 0.142 0.1947
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0067 0.2787 0.388
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0416 0.0482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.1254 0.1846
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.3128 0.4369
Schistosoma mansoni thyroid hormone receptor 0.001 0.0116 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0286 0.0296
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0322 0.0378
Brugia malayi SH2 domain containing protein 0.0009 0.0079 0.0031
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0013 0.027 0.0274
Onchocerca volvulus 0.0023 0.07 0.3372
Loa Loa (eye worm) hypothetical protein 0.0017 0.043 0.0503
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.142 0.2104
Schistosoma mansoni ap endonuclease 0.002 0.0566 0.0773
Brugia malayi protein-tyrosine kinase 0.0067 0.2787 0.3899
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0322 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0116 0.0083
Entamoeba histolytica hypothetical protein 0.0038 0.142 0.5826
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0322 0.0348
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0566 0.0698
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0322 0.0392
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0023 0.0706 0.0009
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0074 0.3128 0.4369
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0116 0.0052
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0009 0.0079 0.0325
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0116 0.0052
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0074 0.3128 0.4369
Mycobacterium ulcerans lipase LipD 0.0034 0.1254 0.122
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.1254 0.1039
Mycobacterium tuberculosis Conserved protein 0.0034 0.1254 0.0903
Schistosoma mansoni tyrosine kinase 0.0017 0.042 0.0545
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0052
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0074 0.3128 0.4369
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.042 0.0488
Schistosoma mansoni tyrosine kinase 0.0017 0.042 0.0545
Entamoeba histolytica hypothetical protein 0.0038 0.142 0.5826
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.07 0.2873
Echinococcus granulosus Tolloid protein 1 0.0012 0.0206 0.0182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0416 0.0482
Brugia malayi SH2 domain containing protein 0.0009 0.0079 0.0031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0116 0.0052
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.3128 0.4369
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0116 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.07 0.0326
Brugia malayi hypothetical protein 0.0009 0.0079 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0116 0.0052
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0566 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.042 0.0488
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0116 0.007
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.1254 0.0903
Loa Loa (eye worm) hypothetical protein 0.0015 0.0322 0.0348
Mycobacterium ulcerans beta-lactamase 0.0034 0.1254 0.122
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0706 0.0927
Mycobacterium leprae Probable lipase LipE 0.0034 0.1254 0.0854
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.1254 0.1684
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0116 0.0052
Mycobacterium tuberculosis Conserved protein 0.0034 0.1254 0.0903
Loa Loa (eye worm) hypothetical protein 0.0026 0.086 0.1119
Loa Loa (eye worm) hypothetical protein 0.0017 0.0435 0.0509
Brugia malayi Muscleblind-like protein 0.0157 0.7057 1
Mycobacterium tuberculosis Conserved protein 0.0034 0.1254 0.0903
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0416 0.0482
Echinococcus granulosus c src tyrosine kinase 0.0017 0.042 0.0488
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0706 0.0408

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.578 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.28 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.22 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.194 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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