Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.1592 | 0.0745 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.036 | 0.2588 | 0.3461 |
Onchocerca volvulus | 0.0871 | 0.9025 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0403 | 0.3131 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0331 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0748 | 0.7476 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0905 | 0.9446 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0356 | 0.2547 | 0.1586 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0331 | 0.2228 | 0.2981 |
Loa Loa (eye worm) | fatty acid synthase | 0.0494 | 0.4277 | 0.391 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0331 | 0.2228 | 0.2941 |
Entamoeba histolytica | protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0905 | 0.9446 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0532 | 0.4752 | 0.6337 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0905 | 0.9446 | 0.9446 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0403 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0417 | 0.3311 | 0.443 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.05 | 0.4361 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0417 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | thioesterase | 0.0417 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0748 | 0.7476 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0409 | 0.3214 | 0.4299 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 0.8643 | 0.9054 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0468 | 0.3948 | 0.3521 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0532 | 0.4752 | 0.4276 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.05 | 0.4361 | 0.581 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0905 | 0.9446 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0157 | 0.0042 | 0.0056 |
Trypanosoma brucei | aurora B kinase | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0202 | 0.061 | 0.0817 |
Mycobacterium ulcerans | thioesterase TesA | 0.0417 | 0.3311 | 0.443 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0905 | 0.9446 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0157 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0532 | 0.4752 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0902 | 0.9416 | 1 |
Schistosoma mansoni | protein kinase | 0.0905 | 0.9446 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0325 | 0.2149 | 0.1101 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0748 | 0.7476 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0485 | 0.4168 | 0.5576 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.05 | 0.4361 | 0.581 |
Giardia lamblia | Aurora kinase | 0.0905 | 0.9446 | 0.5 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.05 | 0.4361 | 0.4361 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0905 | 0.9446 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0905 | 0.9446 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0468 | 0.3948 | 0.528 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0532 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0532 | 0.4752 | 0.6357 |
Entamoeba histolytica | protein kinase , putative | 0.0905 | 0.9446 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0748 | 0.7476 | 1 |
Leishmania major | protein kinase, putative | 0.0905 | 0.9446 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0905 | 0.9446 | 0.9446 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0532 | 0.4752 | 0.6337 |
Toxoplasma gondii | aurora kinase | 0.0905 | 0.9446 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.05 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0285 | 0.1644 | 0.2199 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0172 | 0.0229 | 0.0306 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.05 | 0.4361 | 0.5834 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0905 | 0.9446 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0468 | 0.3948 | 0.3948 |
Loa Loa (eye worm) | AUR protein kinase | 0.0905 | 0.9446 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.05 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | AUR protein kinase | 0.0905 | 0.9446 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0532 | 0.4752 | 0.6357 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0905 | 0.9446 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0485 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0403 | 0.3131 | 0.4188 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0905 | 0.9446 | 0.9446 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0905 | 0.9446 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0905 | 0.9446 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.874 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.805 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.801 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.653 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.545 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.409 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.35 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.331 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.168 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.112 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.046 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.847 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.