Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase D1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.097 | 0.3565 | 0.5736 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0065 | 0.0105 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0771 | 0.2777 | 0.3452 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0174 | 0.0417 | 0.0518 |
Brugia malayi | MIR domain containing protein | 0.0174 | 0.0417 | 0.0417 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0937 | 0.3432 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0411 | 0.1353 | 0.1681 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0019 | 0.0031 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0771 | 0.2777 | 0.2777 |
Schistosoma mansoni | protein kinase C mu | 0.0083 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0019 | 0.0031 |
Echinococcus granulosus | expressed protein | 0.0417 | 0.1377 | 0.1712 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0771 | 0.2777 | 0.3452 |
Onchocerca volvulus | 0.0174 | 0.0417 | 1 | |
Loa Loa (eye worm) | ryanodine receptor | 0.0613 | 0.2153 | 0.3463 |
Schistosoma mansoni | ryanodine receptor related | 0.2598 | 1 | 1 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0174 | 0.0417 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1641 | 0.6216 | 0.7726 |
Onchocerca volvulus | 0.0085 | 0.0065 | 0.1561 | |
Schistosoma mansoni | hypothetical protein | 0.0641 | 0.2262 | 0.2262 |
Onchocerca volvulus | 0.0074 | 0.0019 | 0.046 | |
Loa Loa (eye worm) | hypothetical protein | 0.1641 | 0.6216 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0316 | 0.098 | 0.098 |
Leishmania major | hypothetical protein, conserved | 0.0637 | 0.2246 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.2104 | 0.8045 | 1 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0174 | 0.0417 | 0.067 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0083 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.098 | 0.1576 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.2104 | 0.8045 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0411 | 0.1353 | 0.1681 |
Schistosoma mansoni | lipoxygenase | 0.0287 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0055 | 0.0089 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0083 | 0.0056 | 0.0091 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0174 | 0.0417 | 0.0417 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0069 | 0 | 0.5 |
Brugia malayi | cation channel family protein | 0.1111 | 0.412 | 0.412 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0074 | 0.002 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.1602 | 0.2578 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.03 | 0.0914 | 0.0914 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0937 | 0.3432 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0794 | 0.2869 | 0.2869 |
Schistosoma mansoni | lipoxygenase | 0.0411 | 0.1353 | 0.1353 |
Brugia malayi | C1-like domain containing protein | 0.0083 | 0.0056 | 0.0056 |
Echinococcus multilocularis | expressed protein | 0.0417 | 0.1377 | 0.1712 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1641 | 0.6216 | 0.7726 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0174 | 0.0417 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.1683 | 0.2708 |
Onchocerca volvulus | 0.0083 | 0.0055 | 0.1326 | |
Entamoeba histolytica | MIR domain protein | 0.0174 | 0.0417 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8 uM | Inhibition of protein kinase C (PKC) using histone III S protein | ChEMBL. | No reference |
IC50 (binding) | = 8 uM | Inhibition of protein kinase C (PKC) using histone III S protein | ChEMBL. | No reference |
IC50 (binding) | = 210 uM | Inhibition of c-AMP dependent kinase (PKA) using histone II A protein | ChEMBL. | No reference |
IC50 (binding) | = 210 uM | Inhibition of c-AMP dependent kinase (PKA) using histone II A protein | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.