Detailed information for compound 1626512

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 559.077 | Formula: C27H31ClN4O5S
  • H donors: 3 H acceptors: 7 LogP: 3.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CS(=O)(=O)O.O=C(Nc1ccc2c(c1)c(C)nc(n2)N1CCC(CC1)(O)C1CC1)/C=C/c1ccc(cc1)Cl
  • InChi: 1S/C26H27ClN4O2.CH4O3S/c1-17-22-16-21(29-24(32)11-4-18-2-7-20(27)8-3-18)9-10-23(22)30-25(28-17)31-14-12-26(33,13-15-31)19-5-6-19;1-5(2,3)4/h2-4,7-11,16,19,33H,5-6,12-15H2,1H3,(H,29,32);1H3,(H,2,3,4)/b11-4+;
  • InChiKey: MIHQPFFIJBIESF-SODSUQDMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0101 0.3024 0.3024
Plasmodium falciparum multidrug resistance protein 1 0.0317 1 1
Loa Loa (eye worm) hypothetical protein 0.0317 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0101 0.3024 0.0425
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0101 0.3024 0.3024
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0101 0.3024 0.2791
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0249 0.782 1
Schistosoma mansoni multidrug resistance protein 0.0101 0.3024 0.3024
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0101 0.3024 0.3005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0034 0.0841 0.0841
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0317 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0222 0.6934 0.6934
Trypanosoma brucei multidrug resistance protein E 0.0101 0.3024 0.2791
Echinococcus multilocularis ATP binding cassette sub family B 0.0101 0.3024 0.3024
Leishmania major pentamidine resistance protein 1 0.0101 0.3024 0.2102
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0034 0.0841 0.0841
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0034 0.0841 0.0841
Schistosoma mansoni smdr1 0.0101 0.3024 0.3024
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0317 1 1
Entamoeba histolytica P-glycoprotein-2 0.0317 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.0705 0.0705
Echinococcus multilocularis multidrug resistance protein 1 0.0317 1 1
Echinococcus granulosus tyrosine kinase 0.003 0.0735 0.0735
Brugia malayi ABC transporter transmembrane region family protein 0.0101 0.3024 0.3024
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0044 0.1168 0.0297
Brugia malayi ABC transporter 0.0101 0.3024 0.3024
Trypanosoma brucei ATP-binding cassette protein, putative 0.0249 0.782 1
Brugia malayi ABC transporter 0.0095 0.2821 0.2821
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0317 1 1
Loa Loa (eye worm) ABC transporter 0.0101 0.3024 0.2558
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0311 0.9796 0.9796
Echinococcus multilocularis ATP binding cassette sub family B 0.0311 0.9796 0.9796
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0317 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0317 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0101 0.3024 0.2102
Trypanosoma cruzi ABC transporter, putative 0.0044 0.1168 0.0297
Loa Loa (eye worm) multidrug resistance protein 3 0.0317 1 1
Brugia malayi ABC transporter family protein 0.0101 0.3024 0.3024
Trichomonas vaginalis ABC transporter, putative 0.0317 1 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.0893 0.0893
Entamoeba histolytica P-glycoprotein-5 0.0317 1 1
Onchocerca volvulus 0.0317 1 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.003 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0095 0.2821 0.234
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0841 0.0841
Entamoeba histolytica P-glycoprotein-2, putative 0.0095 0.2821 0.234
Echinococcus granulosus ATP binding cassette sub family B 0.0101 0.3024 0.3024
Loa Loa (eye worm) ABC transporter 0.0212 0.6611 0.6384
Echinococcus multilocularis ATP binding cassette sub family B 0.0101 0.3024 0.3024
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0317 1 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0317 1 0.5
Entamoeba histolytica P-glycoprotein 5, putative 0.0095 0.2821 0.234
Echinococcus granulosus ATP binding cassette sub family G 0.0249 0.782 0.782
Plasmodium vivax ABC transporter G family member 2, putative 0.0249 0.782 0.6875
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.0705 0.0705
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0101 0.3024 0.3005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0841 0.0841
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0317 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0317 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0249 0.782 0.782
Trypanosoma cruzi ABC transporter, putative 0.0249 0.782 1
Echinococcus granulosus ATP binding cassette sub family G 0.0249 0.782 0.782
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0317 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0101 0.3024 0.2558
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0101 0.3024 0.2102
Plasmodium falciparum ABC transporter G family member 2 0.0249 0.782 0.6875
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0101 0.3024 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0101 0.3024 0.3024
Entamoeba histolytica ATP-binding cassette protein, putative 0.0101 0.3024 0.2558
Entamoeba histolytica P-glycoprotein 6, putative 0.0101 0.3024 0.2558
Giardia lamblia ABC transporter, putative 0.0101 0.3024 0.0425
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0206 0.6407 0.6024
Brugia malayi hypothetical protein 0.0101 0.3024 0.3024
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0101 0.3024 0.3005
Echinococcus multilocularis ATP binding cassette sub family G 0.0249 0.782 0.782
Echinococcus granulosus ATP binding cassette sub family B 0.0101 0.3024 0.3024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.3024 0.2558
Loa Loa (eye worm) hypothetical protein 0.0101 0.3024 0.2558
Trichomonas vaginalis abcb9, putative 0.0317 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0101 0.3024 0.3024
Toxoplasma gondii ABC transporter family protein 0.0101 0.3024 0.2102
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0101 0.3024 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0841 0.0841
Entamoeba histolytica P-glycoprotein-2 0.0317 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0317 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Schistosoma mansoni multidrug resistance protein 0.0101 0.3024 0.3024
Echinococcus granulosus multidrug resistance protein 1 0.0317 1 1
Echinococcus multilocularis 0.0101 0.3024 0.3024
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0101 0.3024 0.228
Loa Loa (eye worm) SRC-1 0.0034 0.0841 0.0229
Trichomonas vaginalis ABC transporter, putative 0.0317 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0101 0.3024 0.2102
Echinococcus multilocularis tyrosine protein kinase Srms 0.003 0.0735 0.0735
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0317 1 1
Schistosoma mansoni hypothetical protein 0.0206 0.6407 0.6407
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0317 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0841 0.0841
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0101 0.3024 0.3005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0101 0.3024 0.0284
Entamoeba histolytica P-glycoprotein-2, putative 0.0317 1 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0101 0.3024 1
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0044 0.1168 0.0297
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0317 1 1
Schistosoma mansoni multidrug resistance protein 0.0101 0.3024 0.3024
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0249 0.782 0.7532
Entamoeba histolytica ATP-binding cassette sub-family G1, putative 0.0037 0.0964 0.036
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0101 0.3024 0.3024
Schistosoma mansoni tyrosine kinase 0.0034 0.0841 0.0841
Schistosoma mansoni smdr2 0.0317 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0095 0.2821 0.2821
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0317 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Trichomonas vaginalis taga, putative 0.0317 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0249 0.782 1
Brugia malayi protein-tyrosine kinase 0.003 0.0735 0.0735
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0095 0.2821 0.2821
Echinococcus multilocularis tyrosine protein kinase Blk 0.003 0.0735 0.0735
Entamoeba histolytica P-glyco protein 6, putative 0.0317 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0222 0.6934 0.6934
Trypanosoma cruzi multidrug resistance protein E, putative 0.0101 0.3024 0.3005
Toxoplasma gondii ABC transporter, putative 0.0101 0.3024 0.2102
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0101 0.3024 0.2102
Brugia malayi RE11181p 0.0037 0.0964 0.0964
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0101 0.3024 0.2102
Brugia malayi P-glycoprotein-like protein 0.0101 0.3024 0.3024
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0101 0.3024 0.2102
Giardia lamblia Multidrug resistance-associated protein 1 0.0101 0.3024 0.0425
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0101 0.3024 0.3005
Echinococcus multilocularis tyrosine protein kinase HCK 0.0027 0.0627 0.0627
Giardia lamblia ABC transporter 0.0243 0.7616 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0101 0.3024 0.3005
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0101 0.3024 0.2102
Schistosoma mansoni ABC transporter 0.0212 0.6611 0.6611
Loa Loa (eye worm) hypothetical protein 0.0101 0.3024 0.2558
Brugia malayi ABC transporter transmembrane region family protein 0.0095 0.2821 0.2821
Loa Loa (eye worm) hypothetical protein 0.0317 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0034 0.0841 0.0841
Trypanosoma brucei p-glycoprotein 0.0101 0.3024 0.2791
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0101 0.3024 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0317 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0249 0.782 0.7532
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0101 0.3024 0.2102
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Brugia malayi ABC transporter family protein 0.0101 0.3024 0.3024
Schistosoma mansoni ABC transporter 0.0037 0.0964 0.0964
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0841 0.0841
Echinococcus granulosus multidrug resistance protein 1 0.0222 0.6934 0.6934
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0101 0.3024 0.2102
Echinococcus granulosus tyrosine protein kinase Blk 0.003 0.0735 0.0735
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0101 0.3024 0.2102
Brugia malayi hypothetical protein 0.0037 0.0964 0.0964
Schistosoma mansoni multidrug resistance protein 0.0317 1 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0317 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0317 1 1
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0101 0.3024 0.2102
Schistosoma mansoni tyrosine kinase 0.0034 0.0841 0.0841
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0034 0.0841 0.0841
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0249 0.782 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0964 0.036
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0317 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Trichomonas vaginalis abcb9, putative 0.0317 1 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0101 0.3024 0.3005
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0249 0.782 0.7532
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1168 0.0297
Entamoeba histolytica ATP-binding cassette protein, putative 0.0101 0.3024 0.2558
Schistosoma mansoni multidrug resistance protein 0.0095 0.2821 0.2821
Loa Loa (eye worm) hypothetical protein 0.0037 0.0964 0.036
Brugia malayi ABC transporter family protein 0.0317 1 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0317 1 1
Brugia malayi ABC transporter family protein 0.0212 0.6611 0.6611
Schistosoma mansoni multidrug resistance protein 0.0101 0.3024 0.3024
Loa Loa (eye worm) ABC transporter 0.0101 0.3024 0.2558
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0249 0.782 0.782
Schistosoma mansoni multidrug resistance protein 0.0317 1 1
Loa Loa (eye worm) hypothetical protein 0.0311 0.9796 0.9783
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0222 0.6934 0.573
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0249 0.782 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0034 0.0841 0.0841
Echinococcus multilocularis multidrug resistance protein 1 0.0317 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0101 0.3024 0.2558
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0841 0.0841
Giardia lamblia MRP-like ABC transporter 0.0101 0.3024 0.0425
Echinococcus granulosus tyrosine protein kinase HCK 0.0027 0.0627 0.0627
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0101 0.3024 0.3005
Brugia malayi SRC-1 0.0034 0.0841 0.0841
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0317 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0101 0.3024 0.2102
Schistosoma mansoni multidrug resistance protein 0.0101 0.3024 0.3024
Schistosoma mansoni multidrug resistance protein 0.0317 1 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0317 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.0101 0.3024 0.2558
Entamoeba histolytica P-glycoprotein 6, putative 0.0101 0.3024 0.2558
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.2821 0.234
Echinococcus granulosus multidrug resistance protein 1 0.0317 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0841 0.0841
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0101 0.3024 0.2791
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0101 0.3024 0.228
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0317 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0101 0.3024 0.3024
Trichomonas vaginalis abcb9, putative 0.0317 1 1
Loa Loa (eye worm) ABC transporter 0.0101 0.3024 0.2558
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0841 0.0841
Echinococcus multilocularis multidrug resistance associated protein 7 0.0101 0.3024 0.3024
Echinococcus granulosus tyrosine protein kinase Src64B 0.0034 0.0841 0.0841
Leishmania major ABC-thiol transporter 0.0101 0.3024 0.2102
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0034 0.0841 0.0841
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1168 0.0297
Loa Loa (eye worm) hypothetical protein 0.0037 0.0964 0.036
Trypanosoma brucei ABC transporter, putative 0.0249 0.782 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0317 1 1
Leishmania major p-glycoprotein 0.0317 1 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0101 0.3024 0.2558
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0101 0.3024 0.2791
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0101 0.3024 0.3005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0317 1 1
Loa Loa (eye worm) TK protein kinase 0.003 0.0735 0.0116
Trichomonas vaginalis ABC transporter, putative 0.0317 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Entamoeba histolytica ABC transporter, putative 0.0249 0.782 0.7674
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0101 0.3024 0.2791
Echinococcus granulosus multidrug resistance associated protein 1 0.0101 0.3024 0.3024
Entamoeba histolytica hypothetical protein 0.0101 0.3024 0.2558
Entamoeba histolytica ABC transporter, putative 0.0101 0.3024 0.2558
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0034 0.0841 0.0841
Entamoeba histolytica P-glycoprotein 5, putative 0.0317 1 1
Leishmania major p-glycoprotein e 0.0101 0.3024 0.2102
Trichomonas vaginalis ABC transporter, putative 0.0317 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0317 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0101 0.3024 0.2102
Entamoeba histolytica P-glycoprotein-1 0.0317 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0101 0.3024 0.2102
Echinococcus multilocularis ATP binding cassette sub family G 0.0249 0.782 0.782
Brugia malayi multidrug resistance related protein 1 0.0101 0.3024 0.3024
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0893 0.0284
Echinococcus granulosus ATP binding cassette sub family G 0.0249 0.782 0.782
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0735 0.0735
Echinococcus multilocularis multidrug resistance associated protein 1 0.0101 0.3024 0.3024
Brugia malayi ABC transporter family protein 0.0101 0.3024 0.3024

Activities

Activity type Activity value Assay description Source Reference
Fu (ADMET) = 0.2 % Unbound fraction in in mouse plasma ChEMBL. 22497763

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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