Detailed information for compound 1628424

Basic information

Technical information
  • TDR Targets ID: 1628424
  • Name: 1-[2-(3,4-dimethoxyphenyl)ethyl]-3-[(1,3-diox oinden-2-ylidene)methyl]thiourea
  • MW: 396.46 | Formula: C21H20N2O4S
  • H donors: 2 H acceptors: 2 LogP: 3.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNC(=S)NC=C2C(=O)c3c(C2=O)cccc3)ccc1OC
  • InChi: 1S/C21H20N2O4S/c1-26-17-8-7-13(11-18(17)27-2)9-10-22-21(28)23-12-16-19(24)14-5-3-4-6-15(14)20(16)25/h3-8,11-12H,9-10H2,1-2H3,(H2,22,23,28)
  • InChiKey: DJZWZFBSAIOBPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[2-(3,4-dimethoxyphenyl)ethyl]-3-[(1,3-dioxoindan-2-ylidene)methyl]thiourea
  • 1-[2-(3,4-dimethoxyphenyl)ethyl]-3-[(1,3-dioxo-2-indanylidene)methyl]thiourea
  • 3-[(1,3-diketoindan-2-ylidene)methyl]-1-[2-(3,4-dimethoxyphenyl)ethyl]thiourea
  • AIDS-142039
  • AIDS142039
  • N-(2-(3,4-Dimethoxyphenyl)ethyl)-N'-((1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thiourea
  • NSC658791
  • NCI60_020674

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0024 0.0024
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0856 0.1872 0.3384
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0856 0.1872 0.5222
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0068 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0068 0.0068
Echinococcus multilocularis musashi 0.0024 0.0022 0.0119
Schistosoma mansoni lamin 0.0024 0.0022 0.0022
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0238 0.0499 0.0856
Onchocerca volvulus 0.0024 0.0022 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0029 0.0034 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Loa Loa (eye worm) hypothetical protein 0.0031 0.0036 0.0036
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0238 0.0499 0.0499
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0238 0.0499 0.0499
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0238 0.0499 0.0856
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0238 0.0499 0.2663
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0238 0.0499 0.0499
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1855 0.4094 0.7472
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0238 0.0499 0.2663
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0022 0.0022
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.006 0.0319
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0238 0.0499 0.0499
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0856 0.1872 0.5222
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2473 0.5467 1
Loa Loa (eye worm) PDE1B protein 0.0238 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0618 0.1342 0.1342
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0024 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.006 0.0319
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0238 0.0499 0.2663
Plasmodium falciparum GAF domain-related protein, putative 0.0618 0.1342 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0068 0.0068
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0856 0.1872 1
Trichomonas vaginalis conserved hypothetical protein 0.2473 0.5467 1
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.0499 0.0856
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Mycobacterium ulcerans putative regulatory protein 0.0618 0.1342 0.2683
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2473 0.5467 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.2235 0.4937 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.4512 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Echinococcus multilocularis lamin dm0 0.0024 0.0022 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.0499 0.0856
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1855 0.4094 0.7472
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0238 0.0499 0.1341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.006 0.006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.0499 0.1341
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0238 0.0499 0.1341
Echinococcus multilocularis neuropeptide receptor A26 0.0416 0.0894 0.4773
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.0499 0.1341
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0238 0.0499 0.1341
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0238 0.0499 0.0856
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0856 0.1872 0.1872
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Giardia lamblia Hypothetical protein 0.0238 0.0499 0.5
Echinococcus multilocularis expressed protein 0.003 0.0035 0.0187
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0856 0.1872 1
Echinococcus granulosus X box binding protein 1 0.0258 0.0542 0.2895
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0029 0.0034 0.0027
Echinococcus granulosus intermediate filament protein 0.0024 0.0022 0.0119
Loa Loa (eye worm) hypothetical protein 0.0238 0.0499 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.0618 0.1342 0.2409
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0856 0.1872 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.006 0.006
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Toxoplasma gondii hypothetical protein 0.0618 0.1342 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0856 0.1872 0.1872
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.4512 1 1
Toxoplasma gondii hypothetical protein 0.0618 0.1342 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0238 0.0499 0.1341
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0856 0.1872 0.5222
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Mycobacterium leprae conserved hypothetical protein 0.0618 0.1342 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2473 0.5467 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0238 0.0499 0.0499
Echinococcus granulosus expressed protein 0.003 0.0035 0.0187
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0238 0.0499 0.2663
Leishmania major hypothetical protein, conserved 0.0238 0.0499 0.1341
Trichomonas vaginalis conserved hypothetical protein 0.0618 0.1342 0.2409
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.0499 0.1341
Trichomonas vaginalis conserved hypothetical protein 0.0618 0.1342 0.2409
Toxoplasma gondii GAF domain-containing protein 0.0618 0.1342 1
Mycobacterium ulcerans putative regulatory protein 0.0618 0.1342 0.2683
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0238 0.0499 0.2663
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.2235 0.4937 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0238 0.0499 0.0499
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis rotamase, putative 0.003 0.0035 0.0003
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0238 0.0499 0.2663
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Leishmania major cAMP-specific phosphodiesterase, putative 0.0238 0.0499 0.1341
Giardia lamblia hypothetical protein 0.0238 0.0499 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0022 0.0022
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Echinococcus granulosus neuropeptide receptor A26 0.0416 0.0894 0.4773
Onchocerca volvulus 0.0024 0.0022 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0856 0.1872 0.5222
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Schistosoma mansoni hypothetical protein 0.0258 0.0542 0.0542
Brugia malayi Cytochrome P450 family protein 0.0025 0.0024 0.0024
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0238 0.0499 0.1341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.006 0.0319
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0238 0.0499 0.0856
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0238 0.0499 0.0856
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0238 0.0499 0.2663
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0238 0.0499 0.0856
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Loa Loa (eye worm) hypothetical protein 0.0045 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0031 0.0036 0.0036
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0238 0.0499 0.0499
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0238 0.0499 0.1341
Echinococcus multilocularis neuropeptide s receptor 0.0416 0.0894 0.4773
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0238 0.0499 0.2663
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0029 0.0034 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trypanosoma brucei hypothetical protein, conserved 0.0238 0.0499 0.1341
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0238 0.0499 0.2663
Plasmodium vivax hypothetical protein, conserved 0.0618 0.1342 1
Echinococcus granulosus neuropeptide s receptor 0.0416 0.0894 0.4773
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0036 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.1617 0.3564 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.006 0.0319
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Echinococcus multilocularis lamin 0.0024 0.0022 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Schistosoma mansoni lamin 0.0024 0.0022 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0856 0.1872 0.3384
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0238 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0238 0.0499 0.0499
Leishmania major hypothetical protein, conserved 0.1617 0.3564 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0238 0.0499 0.2663
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0238 0.0499 0.0856
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1617 0.3564 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0238 0.0499 0.0856
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.003 0.0035 0.0035
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0238 0.0499 0.2663
Echinococcus granulosus lamin 0.0024 0.0022 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0618 0.1342 0.2409
Brugia malayi Cytochrome P450 family protein 0.0025 0.0024 0.0024
Schistosoma mansoni intermediate filament proteins 0.0024 0.0022 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0238 0.0499 0.1341
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.003 0.0035 0.0035
Echinococcus multilocularis X box binding protein 1 0.0258 0.0542 0.2895
Toxoplasma gondii hypothetical protein 0.0618 0.1342 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0035 0.0003
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0034 0.5
Brugia malayi intermediate filament protein 0.0024 0.0022 0.0022
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0238 0.0499 0.0499
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0029 0.0034 0.0027
Echinococcus granulosus lamin dm0 0.0024 0.0022 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Leishmania major hypothetical protein, conserved 0.0238 0.0499 0.1341
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1617 0.3564 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0238 0.0499 0.1341
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.0499 0.1341
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.0499 0.1341
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0238 0.0499 0.1341
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0238 0.0499 0.0856
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0856 0.1872 0.3384
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0238 0.0499 0.1341
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.006 0.006
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0856 0.1872 0.5222
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0238 0.0499 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0238 0.0499 0.2663
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0238 0.0499 0.3554
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.0499 0.1341
Mycobacterium tuberculosis Conserved hypothetical protein 0.1617 0.3564 0.6179
Schistosoma mansoni rotamase 0.003 0.0035 0.0035
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0024 0.0024
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0856 0.1872 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0238 0.0499 0.0856
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.006 0.006

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.364 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.13 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.557 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.031 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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