Detailed information for compound 1633436

Basic information

Technical information
  • TDR Targets ID: 1633436
  • Name: methyl 5-oxo-1-[phenyl-(3,4,5-trimethoxypheny l)methyl]pyrrolidine-2-carboxylate
  • MW: 399.437 | Formula: C22H25NO6
  • H donors: 0 H acceptors: 2 LogP: 2.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1CCC(=O)N1C(c1cc(OC)c(c(c1)OC)OC)c1ccccc1
  • InChi: 1S/C22H25NO6/c1-26-17-12-15(13-18(27-2)21(17)28-3)20(14-8-6-5-7-9-14)23-16(22(25)29-4)10-11-19(23)24/h5-9,12-13,16,20H,10-11H2,1-4H3
  • InChiKey: UWZLSLHQRNSPOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-oxo-1-[phenyl-(3,4,5-trimethoxyphenyl)methyl]-2-pyrrolidinecarboxylic acid methyl ester
  • 5-keto-1-[phenyl-(3,4,5-trimethoxyphenyl)methyl]pyrrolidine-2-carboxylic acid methyl ester
  • AIDS036719
  • DL-Proline, 5-oxo-1-[phenyl(3,4,5-trimethoxyphenyl)methyl]-, methyl ester
  • AIDS-036719
  • NCI60_026083
  • NSC673623

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0009 0.0009
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.2427 0.2614 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0037 0.0769
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.001 0.0003
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2799 0.302 0.3014
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0479 0.0486 1
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0009 0.0009
Plasmodium falciparum phosphodiesterase delta, putative 0.0372 0.0369 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0372 0.0369 0.036
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.0444 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1203 0.1276 0.127
Echinococcus multilocularis geminin 0.0205 0.0186 0.0177
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0372 0.0369 0.7603
Trypanosoma brucei hypothetical protein, conserved 0.0372 0.0369 0.8301
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Loa Loa (eye worm) hypothetical protein 0.006 0.0028 0.0028
Brugia malayi nuclear receptor NHR-88 0.0043 0.0009 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0009 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0009 0.0002
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0372 0.0369 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0009 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0009 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0009 0.0002
Brugia malayi Cytochrome P450 family protein 0.0138 0.0113 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0138 0.0113 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0009 0.0002
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0479 0.0486 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0009 0.0002
Toxoplasma gondii hypothetical protein 0.0068 0.0037 0.0124
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2427 0.2614 0.2607
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0372 0.0369 0.0362
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.2799 0.302 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0009 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0369 0.8301
Loa Loa (eye worm) hypothetical protein 0.0365 0.0361 0.0361
Loa Loa (eye worm) hyaluronidase 0.919 1 1
Loa Loa (eye worm) hypothetical protein 0.2799 0.302 0.302
Schistosoma mansoni coup transcription factor 0.0043 0.0009 0.0002
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.041 0.0411 0.8464
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.919 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0037 0.0769
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 0.7603
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.044 0.0444 0.0436
Loa Loa (eye worm) hypothetical protein 0.0493 0.0501 0.0501
Echinococcus granulosus bifunctional protein NCOAT 0.919 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Brugia malayi MH2 domain containing protein 0.0144 0.012 0.0113
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0372 0.0369 0.036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0028 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0009 0.0009
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.041 0.0411 0.8464
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0372 0.0369 0.8301
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0009 0.0002
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.044 0.0444 0.9139
Schistosoma mansoni Hyaluronidase 0.919 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0372 0.0369 0.7603
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0372 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0009 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0369 0.7603
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.044 0.0444 0.0435
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0016 0.0016
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0372 0.0369 0.8301
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0372 0.0369 0.036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Brugia malayi ecdysteroid receptor 0.0043 0.0009 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0009 0.0002
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0372 0.0369 0.8301
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0372 0.0369 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0009 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0009 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0009 0.0009
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0406 0.0406 0.8372
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 0.7603
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.012 0.012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0009 0.0002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0406 0.0406 0.837
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0406 0.0406 0.0398
Mycobacterium leprae conserved hypothetical protein 0.0034 0 0.5
Echinococcus granulosus geminin 0.0205 0.0186 0.0177
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0016 0.0016
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0372 0.0369 0.8301
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0372 0.0369 0.0362
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0372 0.0369 0.0362
Loa Loa (eye worm) hypothetical protein 0.3904 0.4227 0.4227
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0406 0.0406 0.0398
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0009 0.0002
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0009 0.0002
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0493 0.0501 0.0494
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Loa Loa (eye worm) hypothetical protein 0.0831 0.087 0.087
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0369 0.8301
Trypanosoma brucei cAMP-specific phosphodiesterase 0.044 0.0444 1
Echinococcus multilocularis bifunctional protein NCOAT 0.919 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.0186 0.0179
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0493 0.0501 0.0494
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0406 0.0406 0.837
Brugia malayi nuclear hormone receptor 0.0043 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.1203 0.1276 0.1276
Brugia malayi hypothetical protein 0.0365 0.0361 0.0354
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0028 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0009 0.0002
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0406 0.0406 0.9151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0372 0.0369 0.7603
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0372 0.0369 0.8301
Loa Loa (eye worm) hypothetical protein 0.0372 0.0369 0.0369
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0072 0.0042 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0372 0.0369 1
Entamoeba histolytica hypothetical protein 0.0043 0.001 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0372 0.0369 0.036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0009 0.0002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0406 0.0406 0.0399
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.044 0.0444 0.9139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0009 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0009 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0009 0.0002
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0372 0.0369 0.0362
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Loa Loa (eye worm) hypothetical protein 0.0041 0.0008 0.0008
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 0.8301
Leishmania major hypothetical protein, conserved 0.0372 0.0369 0.8301
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0372 0.0369 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0009 0.0002
Brugia malayi hypothetical protein 0.0043 0.001 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0369 0.8301
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.0444 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.0016 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0009 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0009 0.0002
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0372 0.0369 0.0362
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2427 0.2614 0.2607
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2799 0.302 0.3014
Leishmania major cAMP-specific phosphodiesterase, putative 0.0372 0.0369 0.8301
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0009 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0009 0.0002
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0028 0.0028
Plasmodium falciparum phosphodiesterase gamma, putative 0.0372 0.0369 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.2427 0.2614 0.2614
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.0444 1
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0369 0.8301
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0016 0.0254
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0406 0.0406 0.837
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.044 0.0444 0.0435
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 0.8301
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0009 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0009 0.0002
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0372 0.0369 0.8301
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0372 0.0369 0.0362
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0406 0.0406 0.8372
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0369 0.8301
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0372 0.0369 0.0362
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0016 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.012 0.012
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 0.7603
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 1
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0016 0.0254
Leishmania major cytochrome p450-like protein 0.0048 0.0016 0.0254
Schistosoma mansoni hypothetical protein 0.0043 0.001 0.0003
Trypanosoma brucei cAMP-specific phosphodiesterase 0.044 0.0444 1
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0369 0.7603
Brugia malayi Cytochrome P450 family protein 0.0048 0.0016 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0009 0.0002
Entamoeba histolytica hypothetical protein 0.0043 0.001 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0372 0.0369 0.0362
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.001 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0016 0.0254
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.2799 0.302 0.3015
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 0.7603
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0479 0.0486 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.2799 0.302 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0372 0.0369 0.036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0372 0.0369 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0369 0.8301
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0009 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0037 0.0769
Loa Loa (eye worm) PDE1B protein 0.0372 0.0369 0.0369
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Entamoeba histolytica hypothetical protein 0.0043 0.001 0.5
Brugia malayi steroid hormone receptor 0.0043 0.0009 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0016 0.375
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2799 0.302 0.3014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Leishmania major hypothetical protein, conserved 0.0372 0.0369 0.8301
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0372 0.0369 0.036
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.0444 0.9139
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0372 0.0369 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0009 0.0009
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0072 0.0042 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0479 0.0486 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0372 0.0369 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0372 0.0369 0.7603
Onchocerca volvulus 0.0365 0.0361 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0372 0.0369 0.8301
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.044 0.0444 0.9139
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0372 0.0369 0.0362
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2799 0.302 0.3014
Schistosoma mansoni hypothetical protein 0.0205 0.0186 0.0179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0372 0.0369 0.1222
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0005 0.1084
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0372 0.0369 0.0362
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0043 0.001 0.5

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.662 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.532 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.259 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.214 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.205 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.158 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.094 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.003 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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