Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0368 | 0.3149 | 0.9458 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0042 | 0.0206 | 0.0367 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0368 | 0.3149 | 0.9458 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0182 | 0.1476 | 1 |
Trypanosoma cruzi | reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0368 | 0.3149 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0042 | 0.0206 | 0.0113 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0368 | 0.3149 | 1 |
Plasmodium falciparum | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.0321 | 0.0745 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0141 | 0.1099 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0368 | 0.3149 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0141 | 0.1099 | 0.3289 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0065 | 0.0418 | 0.0681 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Leishmania major | oxidoreductase-like protein | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | p450 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0141 | 0.1099 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0368 | 0.3149 | 0.9458 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0042 | 0.0206 | 0.0368 |
Mycobacterium tuberculosis | Probable reductase | 0.0124 | 0.0953 | 0.8562 |
Brugia malayi | flavodoxin family protein | 0.0368 | 0.3149 | 0.5615 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0441 | 0.0434 |
Echinococcus granulosus | methionine synthase reductase | 0.0227 | 0.1879 | 0.5376 |
Chlamydia trachomatis | sulfite reductase | 0.0227 | 0.1879 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.0321 | 0.0745 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.0321 | 0.0745 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0292 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0441 | 0.035 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0141 | 0.1099 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.5608 | 0.5567 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.0321 | 0.0573 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0292 | 0.0158 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0141 | 0.1099 | 0.3289 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0227 | 0.1879 | 0.1802 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.0321 | 0.0745 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0042 | 0.0206 | 0.0367 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0292 | 0.0275 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0068 | 0.0441 | 0.0753 |
Leishmania major | trypanothione reductase | 0.0055 | 0.0321 | 0.0745 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0321 | 0.0371 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.0321 | 0.1646 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.0321 | 0.023 |
Leishmania major | reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0138 | 0.1078 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0368 | 0.3149 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0141 | 0.1099 | 0.3289 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0368 | 0.3149 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0227 | 0.1879 | 0.3096 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0042 | 0.0206 | 0.0812 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0326 | 0.2771 | 0.8764 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0124 | 0.0953 | 0.8562 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0068 | 0.0441 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.5608 | 0.5567 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0292 | 0.0275 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0321 | 0.0371 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0292 | 0.0158 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.3149 | 0.3084 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0185 | 0.1501 | 0.2398 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0141 | 0.1099 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.0321 | 0.1322 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0068 | 0.0441 | 0.0753 |
Leishmania major | cytochrome P450 reductase, putative | 0.0326 | 0.2771 | 0.8764 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0141 | 0.1099 | 0.5 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | nitrate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0472 | 0.4094 | 0.4038 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0368 | 0.3149 | 0.5447 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0124 | 0.0953 | 0.8562 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.0321 | 0.023 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Echinococcus multilocularis | methionine synthase reductase | 0.0227 | 0.1879 | 0.5376 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0182 | 0.1476 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0182 | 0.1476 | 0.2351 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0124 | 0.0953 | 0.8562 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0138 | 0.1078 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0068 | 0.0441 | 0.0785 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0368 | 0.3149 | 1 |
Treponema pallidum | flavodoxin | 0.0141 | 0.1099 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0368 | 0.3149 | 0.5615 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0441 | 0.0434 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0326 | 0.2771 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0368 | 0.3149 | 0.572 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0141 | 0.1099 | 0.3289 |
Schistosoma mansoni | hypothetical protein | 0.0386 | 0.3318 | 0.576 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0368 | 0.3149 | 0.9458 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0042 | 0.0206 | 0.0113 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0138 | 0.1078 | 1 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0042 | 0.0206 | 0.0812 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0368 | 0.3149 | 1 |
Onchocerca volvulus | 0.0068 | 0.0441 | 0.0523 | |
Brugia malayi | flavodoxin family protein | 0.0141 | 0.1099 | 0.1959 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0368 | 0.3149 | 1 |
Echinococcus multilocularis | geminin | 0.0386 | 0.3318 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0068 | 0.0441 | 0.0753 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0368 | 0.3149 | 0.3084 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.064 | 0.5608 | 1 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0141 | 0.1099 | 0.5 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Brugia malayi | FAD binding domain containing protein | 0.0227 | 0.1879 | 0.335 |
Trichomonas vaginalis | set domain proteins, putative | 0.0538 | 0.4683 | 1 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0042 | 0.0206 | 0.0367 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0141 | 0.1099 | 0.1014 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0326 | 0.2771 | 0.4667 |
Plasmodium vivax | hypothetical protein, conserved | 0.0141 | 0.1099 | 0.3289 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0368 | 0.3149 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0368 | 0.3149 | 1 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0094 | 0.0168 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0138 | 0.1078 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0292 | 0.0158 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0441 | 0.0434 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0042 | 0.0206 | 0.0367 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0292 | 0.052 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0141 | 0.1099 | 0.3289 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0368 | 0.3149 | 1 |
Giardia lamblia | Hypothetical protein | 0.0326 | 0.2771 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | p450 reductase, putative | 0.0368 | 0.3149 | 1 |
Plasmodium falciparum | ferredoxin--NADP reductase | 0.0042 | 0.0206 | 0.0367 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0068 | 0.0441 | 0.2507 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.0321 | 0.0745 |
Schistosoma mansoni | hypothetical protein | 0.0386 | 0.3318 | 0.576 |
Leishmania major | nitrate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0141 | 0.1099 | 0.3289 |
Brugia malayi | glutathione reductase | 0.0055 | 0.0321 | 0.0573 |
Plasmodium vivax | SET domain protein, putative | 0.0068 | 0.0441 | 0.1134 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0124 | 0.0953 | 0.8562 |
Leishmania major | p450 reductase, putative | 0.0368 | 0.3149 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0292 | 0.0275 |
Brugia malayi | diaphorase | 0.0042 | 0.0206 | 0.0368 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0042 | 0.0206 | 0.0367 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.0321 | 0.0745 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0124 | 0.0953 | 0.8562 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0292 | 0.02 |
Onchocerca volvulus | 0.0538 | 0.4683 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0472 | 0.4094 | 0.73 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.064 | 0.5608 | 1 |
Echinococcus granulosus | geminin | 0.0386 | 0.3318 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.