TDR Targets

Basic information

Technical information

TDR Targets ID: 1636823
Name: 4-(1H-pyrazol-4-yl)quinoline
MW: 195.22 | Formula: C12H9N3
H donors: 1 H acceptors: 2 LogP: 2.11 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: n1[nH]cc(c1)c1ccnc2c1cccc2
InChi: 1S/C12H9N3/c1-2-4-12-11(3-1)10(5-6-13-12)9-7-14-15-8-9/h1-8H,(H,14,15)
InChiKey: PJKFKLYKZFIEHG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

Peakdale1_002057
ZINC01502382

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.004	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0181	0.0163
Echinococcus multilocularis	tyrosine protein kinase HCK	0.004	0.0101	0.1223
Echinococcus multilocularis	raf serine:threonine protein kinase	0.004	0.0101	0.1223
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0267	0.0267
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Onchocerca volvulus		0.0065	0.0623	0.1245
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0623	0.1133
Entamoeba histolytica	serine/threonine kinase, putative	0.004	0.0101	0.078
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.0101	0.5
Schistosoma mansoni	tyrosine kinase	0.0065	0.0623	0.8832
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0065	0.0623	0.0623
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Schistosoma mansoni	hypothetical protein	0.004	0.0101	0.1428
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus multilocularis	epidermal growth factor receptor	0.004	0.0101	0.1223
Schistosoma mansoni	metabotropic glutamate receptor	0.0051	0.033	0.468
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.004	0.0101	0.5
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Trypanosoma cruzi	protein kinase, putative	0.004	0.0101	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.004	0.0101	0.0101
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	activated cdc42 kinase 1	0.004	0.0101	0.1223
Echinococcus granulosus	tyrosine kinase	0.0065	0.0623	0.0623
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.0101	0.5
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus granulosus	retinal guanylyl cyclase 2	0.004	0.0101	0.0101
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0061	0.0534	0.0954
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0267	0.0422
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0043	0.0172	0.0172
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.004	0.0101	0.1428
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0065	0.0623	0.0623
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0065	0.0623	0.7567
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0065	0.0623	0.7567
Brugia malayi	hypothetical protein	0.004	0.0101	0.0088
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0043	0.0172	0.2086
Brugia malayi	ephrin receptor 1 precursor	0.004	0.0101	0.0088
Toxoplasma gondii	protein kinase	0.004	0.0101	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0065	0.0623	0.7567
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Schistosoma mansoni	tyrosine kinase	0.0065	0.0623	0.8832
Brugia malayi	integrin-linked kinase	0.004	0.0101	0.0088
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.004	0.0101	0.1223
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0065	0.0623	0.0623
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0623	0.1133
Echinococcus granulosus	tyrosine protein kinase HCK	0.004	0.0101	0.0101
Schistosoma mansoni	serine/threonine RGC	0.004	0.0101	0.1428
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.004	0.0101	0.0101
Schistosoma mansoni	tyrosine protein kinase	0.004	0.0101	0.1428
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0043	0.0172	0.023
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.004	0.0101	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Echinococcus granulosus	protein kinase	0.004	0.0101	0.0101
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	protein tyrosine kinase	0.004	0.0101	0.1223
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.004	0.0101	0.0101
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0101	0.1428
Toxoplasma gondii	STE kinase	0.004	0.0101	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.004	0.0101	0.1223
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	epidermal growth factor receptor	0.004	0.0101	0.0101
Echinococcus multilocularis	tyrosine protein kinase shark	0.0065	0.0623	0.7567
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.004	0.0101	0.1223
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0623	0.1133
Onchocerca volvulus		0.0046	0.0219	0.0281
Echinococcus granulosus	tyrosine protein kinase csk	0.004	0.0101	0.0101
Giardia lamblia	Kinase, NEK	0.004	0.0101	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.004	0.0101	0.0101
Schistosoma mansoni	tyrosine kinase	0.0046	0.0219	0.3099
Onchocerca volvulus		0.0065	0.0623	0.1245
Loa Loa (eye worm)	TK/ROR protein kinase	0.0043	0.0172	0.0143
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Brugia malayi	SH2 domain containing protein	0.0065	0.0623	0.1133
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.004	0.0101	0.1428
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.004	0.0101	0.078
Plasmodium vivax	protein kinase, putative	0.004	0.0101	0.5
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Entamoeba histolytica	receptor protein kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0267	0.0336
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	0.0101	0.1223
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0065	0.0623	0.0623
Brugia malayi	SH2 domain containing protein	0.0065	0.0623	0.1133
Giardia lamblia	Kinase	0.004	0.0101	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.004	0.0101	0.078
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.004	0.0101	0.0088
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Leishmania major	protein kinase, putative	0.004	0.0101	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus granulosus	tyrosine protein kinase pr2	0.004	0.0101	0.0101
Plasmodium falciparum	tyrosine kinase-like protein	0.004	0.0101	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0823	0.1458
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0046	0.0219	0.2655
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.004	0.0101	0.1223
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	roundabout 2	0.0044	0.0181	0.2203
Echinococcus multilocularis	activin receptor type	0.004	0.0101	0.1223
Trypanosoma brucei	Flagellum attachment zone protein 20	0.004	0.0101	0.5
Schistosoma mansoni	tyrosine kinase	0.0046	0.0219	0.3099
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Entamoeba histolytica	serine/threonine kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus granulosus	tyrosine protein kinase shark	0.0065	0.0623	0.0623
Entamoeba histolytica	ankyrin repeat protein	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Leishmania major	hypothetical protein, conserved	0.004	0.0101	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0065	0.0623	0.7567
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.004	0.0101	0.5
Plasmodium falciparum	protein kinase, putative	0.004	0.0101	0.5
Echinococcus granulosus	activin receptor type	0.004	0.0101	0.0101
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0065	0.0623	0.0623
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.004	0.0101	0.0101
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.0623	0.0623
Trypanosoma brucei	Pseudokinase, putative	0.004	0.0101	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0282	0.5056	1
Entamoeba histolytica	receptor protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0267	0.3789
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.004	0.0101	0.1428
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Echinococcus multilocularis	c src tyrosine kinase	0.0065	0.0623	0.7567
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.004	0.0101	0.1223
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0065	0.0623	0.7567
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Onchocerca volvulus	Tyrosine kinase homolog	0.0245	0.4296	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0267	0.0267
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0065	0.0623	0.7567
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	0.0101	0.1223
Entamoeba histolytica	ankyrin repeat protein	0.004	0.0101	0.078
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.004	0.0101	0.0088
Entamoeba histolytica	serine/threonine kinase, putative	0.004	0.0101	0.078
Onchocerca volvulus		0.0201	0.3405	0.7875
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.004	0.0101	0.0101
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0623	0.1133
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Schistosoma mansoni	hypothetical protein	0.0038	0.0057	0.0802
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Entamoeba histolytica	hypothetical protein, conserved	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.0623	0.0623
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus granulosus	retinal guanylyl cyclase 2	0.004	0.0101	0.0101
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.004	0.0101	0.078
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0267	0.3789
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Leishmania major	protein kinase, putative	0.004	0.0101	0.5
Giardia lamblia	Protein 21.1	0.004	0.0101	0.5
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	tyrosine protein kinase	0.004	0.0101	0.1223
Echinococcus multilocularis	insulin receptor	0.004	0.0101	0.1223
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Plasmodium falciparum	protein kinase, putative	0.004	0.0101	0.5
Echinococcus granulosus	integrin linked protein kinase	0.004	0.0101	0.0101
Echinococcus multilocularis	protein kinase	0.004	0.0101	0.1223
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.004	0.0101	0.1223
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.004	0.0101	0.0101
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Brugia malayi	bone morphogenetic protein type 1 receptor	0.004	0.0101	0.0088
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0065	0.0623	0.7567
Schistosoma mansoni	tyrosine kinase	0.0065	0.0623	0.8832
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0267	0.3247
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0219	0.0238
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.004	0.0101	0.1223
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Schistosoma mansoni	tyrosine kinase	0.0052	0.0353	0.5005
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.0101	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.004	0.0101	0.0101
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.004	0.0101	0.0101
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.004	0.0101	0.1223
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Loa Loa (eye worm)	hypothetical protein	0.004	0.011	0.0019
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	0.0101	0.1223
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0075	0.0823	0.0823
Echinococcus multilocularis	tyrosine kinase	0.0046	0.0219	0.2655
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0055	0.0416	0.0718
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0219	0.0238
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	protein kinase	0.0046	0.0219	0.3099
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0219	0.0238
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0101	0.1428
Echinococcus granulosus	insulin receptor	0.004	0.0101	0.0101
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	0.0101	0.1223
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0065	0.0623	0.7567
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.004	0.0101	0.1223
Echinococcus granulosus	receptor type guanylyl cyclase	0.0046	0.0219	0.0219
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.004	0.0101	0.1428
Echinococcus granulosus	tyrosine kinase	0.0065	0.0623	0.0623
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0051	0.033	0.401
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.004	0.0101	0.0088
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0623	0.1054
Echinococcus multilocularis	FL cytokine receptor	0.004	0.0101	0.1223
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Echinococcus multilocularis	transfer RNA-Thr	0.004	0.0101	0.1223
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0057	0.0057
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Onchocerca volvulus		0.0065	0.0623	0.1245
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0057	0.0687
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Brugia malayi	hypothetical protein	0.004	0.0101	0.0088
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.004	0.0101	0.1223
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.004	0.0101	0.0088
Echinococcus granulosus	kinase suppressor of Ras 1	0.004	0.0101	0.0101
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	kinase suppressor of Ras 1	0.004	0.0101	0.1223
Echinococcus multilocularis	integrin linked protein kinase	0.004	0.0101	0.1223
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.004	0.0101	0.1223
Echinococcus granulosus	natriuretic peptide receptor 1	0.004	0.0101	0.0101
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0623	0.7567
Brugia malayi	Tyrosine-protein kinase abl-1	0.0065	0.0623	0.1133
Schistosoma mansoni	protein tyrosine kinase	0.004	0.0101	0.1428
Echinococcus granulosus	tyrosine protein kinase	0.004	0.0101	0.0101
Echinococcus multilocularis	protein kinase	0.004	0.0101	0.1223
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Onchocerca volvulus		0.0065	0.0623	0.1245
Entamoeba histolytica	tyrosin kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	epidermal growth factor receptor	0.004	0.0101	0.0101
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Echinococcus granulosus	retinal guanylyl cyclase 2	0.004	0.0101	0.0101
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0623	0.7567
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	Raf kinase	0.004	0.0101	0.0088
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	tyrosine protein kinase pr2	0.004	0.0101	0.1223
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0065	0.0623	0.0623
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0065	0.0623	0.7567
Loa Loa (eye worm)	TK protein kinase	0.0065	0.0623	0.1054
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.004	0.0101	0.1223
Mycobacterium ulcerans	hypothetical protein	0.016	0.2561	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Entamoeba histolytica	serine/threonine kinase, putative	0.004	0.0101	0.078
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.016	0.2561	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0101	0.1428
Schistosoma mansoni	tyrosine kinase	0.0065	0.0623	0.8832
Brugia malayi	hypothetical protein	0.0065	0.0623	0.1133
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0065	0.0623	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Schistosoma mansoni	cell adhesion molecule	0.004	0.011	0.1564
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0181	0.0163
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.004	0.0101	0.1428
Schistosoma mansoni	ephrin receptor	0.004	0.0101	0.1428
Echinococcus granulosus	roundabout 2	0.0044	0.0181	0.0181
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0219	0.0238
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Plasmodium falciparum	protein kinase, putative	0.004	0.0101	0.5
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.016	0.2561	0.5
Brugia malayi	SRC-1	0.0065	0.0623	0.1133
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0267	0.3247
Echinococcus multilocularis	natriuretic peptide receptor 1	0.004	0.0101	0.1223
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.0065	0.0623	0.8832
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Echinococcus granulosus	tyrosine protein kinase csk	0.004	0.0101	0.0101
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0065	0.0623	0.7567
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.004	0.0101	0.0088
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0065	0.0623	0.0623
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0065	0.0623	0.8832
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0051	0.033	0.033
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Entamoeba histolytica	cysteine surface protein, putative	0.004	0.0101	0.078
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.0623	0.0623
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Brugia malayi	protein-tyrosine kinase	0.0065	0.0623	0.1133
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Loa Loa (eye worm)	SRC-1	0.0065	0.0623	0.1054
Schistosoma mansoni	tyrosine kinase	0.0065	0.0623	0.8832
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Echinococcus multilocularis	epidermal growth factor receptor	0.004	0.0101	0.1223
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.004	0.0101	0.0101
Brugia malayi	Guanylyl cyclase protein 23	0.0046	0.0219	0.0324
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.004	0.0101	0.0101
Plasmodium vivax	tyrosine kinase-like protein, putative	0.004	0.0101	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.004	0.0101	0.1428
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.004	0.0101	0.0088
Echinococcus multilocularis	tyrosine kinase	0.0065	0.0623	0.7567
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0065	0.0623	0.7567
Entamoeba histolytica	tyrosin kinase, putative	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.004	0.0101	0.1223
Onchocerca volvulus		0.0065	0.0623	0.1245
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0046	0.0219	0.0281
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0623	0.7567
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase Srms	0.0065	0.0623	0.0623
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.004	0.0101	0.1223
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Brugia malayi	Furin-like cysteine rich region family protein	0.004	0.0101	0.0088
Giardia lamblia	Kinase, NEK	0.004	0.0101	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.016	0.2561	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0267	0.3789
Toxoplasma gondii	protein kinase domain-containing protein	0.004	0.0101	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0065	0.0623	0.7567
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0069	0.0705	1
Loa Loa (eye worm)	TK protein kinase	0.0043	0.0172	0.0143
Schistosoma mansoni	ephrin receptor	0.004	0.0101	0.1428
Echinococcus multilocularis	ephrin type A receptor 4 A	0.004	0.0101	0.1223
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Brugia malayi	Receptor family ligand binding region containing protein	0.0046	0.0219	0.0324
Entamoeba histolytica	hypothetical protein	0.004	0.0101	0.078
Brugia malayi	Tyrosine-protein kinase PR2	0.004	0.0101	0.0088
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0057	0.0802
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.016	0.2561	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.004	0.0101	0.5
Echinococcus granulosus	protein tyrosine kinase	0.004	0.0101	0.0101
Onchocerca volvulus		0.0065	0.0623	0.1245
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0623	0.7567
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0065	0.0623	0.0623
Echinococcus granulosus	activated cdc42 kinase 1	0.004	0.0101	0.0101
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0282	0.5056	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.004	0.0101	0.0101
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Loa Loa (eye worm)	glutamate receptor	0.0061	0.0534	0.0873
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.004	0.0101	0.0101
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0065	0.0623	0.0623
Echinococcus granulosus	tyrosine kinase	0.0046	0.0219	0.0219
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Schistosoma mansoni	tyrosine kinase	0.004	0.0101	0.1428
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Trypanosoma brucei	protein kinase, putative	0.004	0.0101	0.5
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Mycobacterium tuberculosis	Probable aminotransferase	0.016	0.2561	0.5
Entamoeba histolytica	protein kinase, putative	0.004	0.0101	0.078
Echinococcus multilocularis	heat shock protein 70	0.004	0.0101	0.1223
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.004	0.0101	0.0101
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Schistosoma mansoni	protein kinase	0.004	0.0101	0.1428
Entamoeba histolytica	tyrosine kinase, putative	0.004	0.0101	0.078
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.004	0.0101	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.004	0.0101	0.078
Loa Loa (eye worm)	TK/ABL protein kinase	0.0065	0.0623	0.1054
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0075	0.0823	1
Echinococcus granulosus	c src tyrosine kinase	0.0065	0.0623	0.0623
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0623	0.1133
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Echinococcus granulosus	tyrosine protein kinase Blk	0.0065	0.0623	0.0623
Echinococcus granulosus	tyrosine protein kinase csk	0.004	0.0101	0.0101
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	0.0101	0.078
Echinococcus granulosus	activated cdc42 kinase 1	0.004	0.0101	0.0101
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0101	0.078
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088
Plasmodium falciparum	tyrosine kinase-like protein	0.004	0.0101	0.5
Brugia malayi	C-terminal src kinase protein 1	0.004	0.0101	0.0088
Loa Loa (eye worm)	TK/FER protein kinase	0.0065	0.0623	0.1054
Trypanosoma cruzi	protein kinase, putative	0.004	0.0101	0.5
Brugia malayi	Protein kinase domain containing protein	0.004	0.0101	0.0088

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 10000 nM	Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization by FLIPR analysis	ChEMBL.	22465637
Emax (binding)	= 6 %	Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization by FLIPR analysis relative to PHCCC	ChEMBL.	22465637

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2022868

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1636823