TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.556 | Formula: C26H30N6O
H donors: 1 H acceptors: 4 LogP: 3.3 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(c(c1)N1CCN(CC1)c1nccnc1)NC(=O)c1cccnc1C1CC1)C
InChi: 1S/C26H30N6O/c1-18(2)20-7-8-22(30-26(33)21-4-3-9-29-25(21)19-5-6-19)23(16-20)31-12-14-32(15-13-31)24-17-27-10-11-28-24/h3-4,7-11,16-19H,5-6,12-15H2,1-2H3,(H,30,33)
InChiKey: YJIJLPSYKAQTIP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0207	0.0487	0.2615
Plasmodium vivax	pyruvate kinase 2, putative	0.0019	0.0004	0.003
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0207	0.0487	0.2615
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0036	0.0049	0.0049
Loa Loa (eye worm)	PDE1B protein	0.0207	0.0487	0.0487
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0057	0.0057
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0057	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0742	0.1862	0.5238
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0057	0.0014
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0049	0.0049
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0207	0.0487	0.2615
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0207	0.0487	0.0487
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0207	0.0487	0.137
Trypanosoma brucei	glucosidase, putative	0.0039	0.0057	0.016
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0487	0.0487
Echinococcus granulosus	geminin	0.0184	0.0429	0.2301
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0004	0.0022
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0289	0.0289
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0031	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.0487	0.0809
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	0.0014
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0207	0.0487	0.137
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0207	0.0487	0.2615
Schistosoma mansoni	alpha-glucosidase	0.0152	0.0347	0.0347
Echinococcus multilocularis	lamin dm0	0.0029	0.0031	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.0535	0.1332	0.2369
Echinococcus granulosus	lysosomal alpha glucosidase	0.0177	0.041	0.2203
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0742	0.1862	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0057	0.0306
Leishmania major	hypothetical protein, conserved	0.0207	0.0487	0.137
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0207	0.0487	0.2615
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0207	0.0487	0.0809
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.1401	0.3556	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Loa Loa (eye worm)	hypothetical protein	0.0029	0.003	0.003
Plasmodium falciparum	GAF domain-related protein, putative	0.0535	0.1332	1
Trypanosoma brucei	GAF domain/TIP41-like family, putative	0.1401	0.3556	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0057	0.0057
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0289	0.0289
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0057	0.016
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Toxoplasma gondii	hypothetical protein	0.0535	0.1332	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0057	0.0304
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.012	0.0645
Echinococcus granulosus	lysine specific demethylase 5A	0.0064	0.012	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0031	0.0031
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0207	0.0487	0.2615
Plasmodium falciparum	pyruvate kinase	0.0036	0.0049	0.037
Echinococcus granulosus	pyruvate kinase	0.0019	0.0004	0.0022
Leishmania major	hypothetical protein, conserved	0.1401	0.3556	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0207	0.0487	0.137
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.012	0.0645
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Schistosoma mansoni	hypothetical protein	0.0184	0.0429	0.0429
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.3657
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.0487	0.137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0177	0.041	0.041
Onchocerca volvulus		0.0102	0.0219	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.0487	0.137
Mycobacterium tuberculosis	Conserved hypothetical protein	0.1401	0.3556	0.7183
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0057	0.016
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0207	0.0487	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0057	0.0014
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0057	0.0014
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.012	0.012
Entamoeba histolytica	hypothetical protein	0.0039	0.0057	0.9864
Schistosoma mansoni	alpha glucosidase	0.0039	0.0057	0.0057
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.0487	0.137
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0004	0.0022
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1607	0.4086	0.7459
Schistosoma mansoni	pyruvate kinase	0.0036	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0039	0.0057	0.0057
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0207	0.0487	0.0487
Toxoplasma gondii	hypothetical protein	0.0535	0.1332	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0207	0.0487	0.2615
Brugia malayi	jmjC domain containing protein	0.0064	0.012	0.012
Echinococcus granulosus	lamin	0.0029	0.0031	0.0169
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0207	0.0487	0.0809
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0207	0.0487	0.0487
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.041	0.2203
Plasmodium vivax	hypothetical protein, conserved	0.0535	0.1332	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0057	0.0304
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0177	0.041	0.041
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0049	0.0049
Leishmania major	hypothetical protein, conserved	0.0207	0.0487	0.137
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.0487	0.137
Echinococcus granulosus	pyruvate kinase	0.0036	0.0049	0.0264
Entamoeba histolytica	hypothetical protein	0.0039	0.0057	0.9864
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0207	0.0487	0.3657
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0207	0.0487	0.0487
Trypanosoma brucei	pyruvate kinase 1, putative	0.0036	0.0049	0.0139
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0049	0.095
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.0809
Mycobacterium leprae	conserved hypothetical protein	0.0535	0.1332	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0207	0.0487	0.2615
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Trypanosoma brucei	hypothetical protein, conserved	0.0207	0.0487	0.137
Echinococcus granulosus	pyruvate kinase	0.0036	0.0049	0.0264
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	0.0014
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0207	0.0487	0.0809
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0742	0.1862	0.5238
Trichomonas vaginalis	conserved hypothetical protein	0.0535	0.1332	0.2369
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0742	0.1862	0.5238
Trypanosoma brucei	pyruvate kinase 1	0.0036	0.0049	0.0139
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0742	0.1862	0.5238
Toxoplasma gondii	pyruvate kinase PyKII	0.0019	0.0004	0.003
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0049	0.095
Loa Loa (eye worm)	hypothetical protein	0.3908	1	1
Plasmodium falciparum	phosphodiesterase delta, putative	0.0207	0.0487	0.3657
Echinococcus granulosus	intermediate filament protein	0.0029	0.0031	0.0169
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.012	0.012
Plasmodium vivax	phosphodiesterase gamma, putative	0.0207	0.0487	0.3657
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0207	0.0487	0.137
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0207	0.0487	0.137
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0057	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0535	0.1332	0.2369
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0049	0.095
Brugia malayi	jmjC domain containing protein	0.0064	0.012	0.012
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0742	0.1862	0.335
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0036	0.0049	0.0139
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.1936	0.4931	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0057	0.016
Entamoeba histolytica	hypothetical protein	0.0039	0.0057	0.9864
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0036	0.0049	0.0139
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.0809
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0742	0.1862	0.335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0207	0.0487	0.0487
Echinococcus granulosus	pyruvate kinase	0.0019	0.0004	0.0022
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Plasmodium falciparum	pyruvate kinase 2	0.0019	0.0004	0.003
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0207	0.0487	0.2615
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.3657
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0742	0.1862	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0207	0.0487	0.0809
Schistosoma mansoni	jumonji domain containing protein	0.0064	0.012	0.012
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0207	0.0487	0.137
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0031	0.0031
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0207	0.0487	0.137
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0487	0.0487
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.3657
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	0.0014
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.0487	0.137
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.1401	0.3556	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.3657
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0057	0.0428
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0207	0.0487	0.3657
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.0487	0.0809
Echinococcus multilocularis	lamin	0.0029	0.0031	0.0169
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0207	0.0487	0.0487
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0021	0.0021
Leishmania major	pyruvate kinase	0.0036	0.0049	0.0139
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0057	0.0306
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.3657
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0207	0.0487	0.2615
Giardia lamblia	hypothetical protein	0.0207	0.0487	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0057	0.0014
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0742	0.1862	0.1862
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.0809
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0742	0.1862	0.5238
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0207	0.0487	0.2615
Brugia malayi	hypothetical protein	0.0039	0.0057	0.0057
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0207	0.0487	0.3657
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Giardia lamblia	Hypothetical protein	0.0207	0.0487	1
Toxoplasma gondii	pyruvate kinase PyK1	0.0036	0.0049	0.037
Plasmodium vivax	pyruvate kinase, putative	0.0036	0.0049	0.037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	0.0014
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0057	1
Echinococcus granulosus	lamin dm0	0.0029	0.0031	0.0169
Brugia malayi	intermediate filament protein	0.0029	0.0031	0.0031
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0049	0.0264
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0207	0.0487	0.137
Schistosoma mansoni	alpha-glucosidase	0.0152	0.0347	0.0347
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Echinococcus granulosus	pyruvate kinase	0.0019	0.0004	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0487	0.0487
Schistosoma mansoni	lamin	0.0029	0.0031	0.0031
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0207	0.0487	0.0809
Giardia lamblia	Pyruvate kinase	0.0036	0.0049	0.0937
Echinococcus multilocularis	geminin	0.0184	0.0429	0.2301
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0742	0.1862	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.0025	0.0021	0.0021
Schistosoma mansoni	pyruvate kinase	0.0036	0.0049	0.0049
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.0809
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.2142	0.5462	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0742	0.1862	0.1862
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.2142	0.5462	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0207	0.0487	0.137
Entamoeba histolytica	hypothetical protein	0.0039	0.0057	0.9864
Schistosoma mansoni	pyruvate kinase	0.0019	0.0004	0.0004
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.2142	0.5462	1
Mycobacterium ulcerans	putative regulatory protein	0.0535	0.1332	0.2627
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.3908	1	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.1936	0.4931	1
Schistosoma mansoni	lamin	0.0029	0.0031	0.0031
Schistosoma mansoni	hypothetical protein	0.0184	0.0429	0.0429
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Echinococcus multilocularis	musashi	0.0029	0.0031	0.0169
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1607	0.4086	0.7459
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0031	0.0031
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0207	0.0487	0.2615
Echinococcus multilocularis	pyruvate kinase	0.0029	0.003	0.0159
Chlamydia trachomatis	pyruvate kinase	0.0036	0.0049	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0031	0.0031
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.0487	0.137
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0742	0.1862	1
Brugia malayi	MH2 domain containing protein	0.0129	0.0289	0.0289
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0036	0.0049	0.0049
Echinococcus multilocularis	lysine specific demethylase 5A	0.0064	0.012	0.0645
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0207	0.0487	0.0809
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0207	0.0487	0.0487
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0049	0.0264
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0004	0.0022
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.041	0.2203
Trichomonas vaginalis	conserved hypothetical protein	0.0535	0.1332	0.2369
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0742	0.1862	0.335
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0207	0.0487	0.3657
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	0.0014
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0535	0.1332	0.2627
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0742	0.1862	0.335
Loa Loa (eye worm)	hypothetical protein	0.0535	0.1332	0.1332
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0207	0.0487	0.0487
Leishmania major	pyruvate kinase	0.0036	0.0049	0.0139
Trichomonas vaginalis	conserved hypothetical protein	0.2142	0.5462	1
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0049	0.0049
Toxoplasma gondii	hypothetical protein	0.0535	0.1332	1
Mycobacterium ulcerans	putative regulatory protein	0.0535	0.1332	0.2627
Toxoplasma gondii	GAF domain-containing protein	0.0535	0.1332	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0207	0.0487	0.137

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	= 21 uM	Cytotoxicity against human HuH7 cells after 3 days by MTS assay	ChEMBL.	24900232

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2011039

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1637036