Detailed information for compound 1638302

Basic information

Technical information
  • TDR Targets ID: 1638302
  • Name: (Z)-N-tert-butyl-N-(furan-3-ylmethyl)-3-pheny lsulfinylprop-2-enamide
  • MW: 331.429 | Formula: C18H21NO3S
  • H donors: 1 H acceptors: 2 LogP: 3.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C(C)(C)C)Cc1cocc1)/C=C\[S+](c1ccccc1)[O-]
  • InChi: 1S/C18H21NO3S/c1-18(2,3)19(13-15-9-11-22-14-15)17(20)10-12-23(21)16-7-5-4-6-8-16/h4-12,14H,13H2,1-3H3/b12-10-
  • InChiKey: MKDWGGNLDHEQMB-BENRWUELSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (Z)-N-tert-butyl-N-(3-furylmethyl)-3-phenylsulfinyl-prop-2-enamide
  • (Z)-N-tert-butyl-N-(3-furylmethyl)-3-phenylsulfinylprop-2-enamide
  • (Z)-N-tert-butyl-N-(3-furylmethyl)-3-phenylsulfinyl-acrylamide
  • (Z)-N-tert-butyl-N-(furan-3-ylmethyl)-3-phenylsulfinyl-prop-2-enamide
  • NSC705337

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0022 0.0207 0.0207
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.004 0.0637 0.0629
Loa Loa (eye worm) beta-lactamase 0.0022 0.0207 0.0199
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0653 0.0653
Onchocerca volvulus 0.0022 0.0207 0.0199
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0376 0.8977 0.8977
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.0248 0.0779
Loa Loa (eye worm) hypothetical protein 0.0076 0.1538 0.1531
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0318 1
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0015 0.0026 0.0423
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0207 0.091
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.2189 0.6864
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0014 0.0008 0.0026
Entamoeba histolytica hypothetical protein 0.0031 0.0414 1
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.0207 0.6508
Echinococcus granulosus beta LACTamase domain containing family member 0.0022 0.0207 0.0207
Mycobacterium tuberculosis Probable reductase 0.0092 0.1934 0.6065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0653 0.2049
Mycobacterium ulcerans hypothetical protein 0.0022 0.0207 0.6508
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0207 0.0207
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0027 0.0318 1
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0207 0.0207
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0026 0.0026
Onchocerca volvulus 0.004 0.0637 0.0629
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0015 0.0026 0.0392
Echinococcus multilocularis lamin dm0 0.004 0.0637 0.0637
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0077 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0022 0.0207 0.0199
Brugia malayi intermediate filament protein 0.004 0.0637 0.0637
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0318 0.7627
Mycobacterium tuberculosis Conserved protein 0.0022 0.0207 0.0649
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0207 0.3167
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0414 0.0414
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0318 0.0318
Brugia malayi T-complex protein 1, beta subunit 0.0015 0.0026 0.0026
Brugia malayi hypothetical protein 0.0258 0.6043 0.6043
Loa Loa (eye worm) hypothetical protein 0.0417 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0318 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0265
Brugia malayi beta-lactamase 0.0022 0.0207 0.0207
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0019 0.0128 0.0128
Brugia malayi latrophilin 2 splice variant baaae 0.0052 0.0942 0.0942
Plasmodium vivax glutathione reductase, putative 0.004 0.0653 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0022 0.0207 0.0649
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.1934 0.6065
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0318 0.4866
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0022 0.0207 0.0199
Plasmodium falciparum T-complex protein 1 subunit beta 0.0015 0.0026 0.0392
Brugia malayi Calcitonin receptor-like protein seb-1 0.0076 0.1538 0.1538
Leishmania major trypanothione reductase 0.004 0.0653 0.0653
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0041 0.0676 0.0676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0026
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0318 0.0318
Schistosoma mansoni lamin 0.004 0.0637 0.0637
Trichomonas vaginalis chaperonin, putative 0.0015 0.0026 0.0805
Brugia malayi cytoplasmic intermediate filament protein 0.0021 0.018 0.018
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0417 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.025 0.025
Brugia malayi beta-lactamase family protein 0.0022 0.0207 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0077 0.1551 0.1544
Brugia malayi hypothetical protein 0.0031 0.0414 0.0414
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.025 0.025
Brugia malayi T-complex protein 1, beta subunit 0.0015 0.0026 0.0026
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0015 0.0026 0.0805
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0318 0.0318
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0417 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.0207 0.0207
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0024 0.0248 0.11
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.0207 0.0207
Mycobacterium tuberculosis Probable lipase LipD 0.0022 0.0207 0.0649
Schistosoma mansoni inositol monophosphatase 0.0027 0.0318 0.0318
Toxoplasma gondii ABC1 family protein 0.0022 0.0207 0.3167
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0077 0.1551 0.1551
Schistosoma mansoni hypothetical protein 0.0024 0.025 0.025
Brugia malayi Thioredoxin reductase 0.004 0.0653 0.0653
Mycobacterium ulcerans hypothetical protein 0.0014 0.0008 0.0265
Loa Loa (eye worm) hypothetical protein 0.0052 0.0942 0.0934
Toxoplasma gondii thioredoxin reductase 0.004 0.0653 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.2189 1
Trichomonas vaginalis esterase, putative 0.0022 0.0207 0.6508
Onchocerca volvulus 0.0022 0.0207 0.0199
Onchocerca volvulus 0.0022 0.0207 0.0199
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0318 0.0318
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0015 0.0026 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0008 0.0008
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0019 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.004 0.0637 0.0629
Mycobacterium tuberculosis Probable esterase LipL 0.0022 0.0207 0.0649
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0021 0.018 0.0172
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0265
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0102
Trypanosoma brucei trypanothione reductase 0.004 0.0653 0.0653
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.1934 0.8833
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0318 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0008 0.0265
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0143 0.3189 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0417 1 1
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0318 0.0318
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.025 0.025
Loa Loa (eye worm) inositol-1 0.0027 0.0318 0.031
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0015 0.0026 0.0026
Brugia malayi glutathione reductase 0.004 0.0653 0.0653
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.0207 0.6508
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0417 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0414 0.0414
Entamoeba histolytica hypothetical protein 0.0031 0.0414 1
Echinococcus granulosus lamin 0.004 0.0637 0.0637
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0417 1 1
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0417 1 1
Echinococcus multilocularis lysosomal protective protein 0.0417 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0014 0.0008 0.0265
Schistosoma mansoni lamin 0.004 0.0637 0.0637
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.0207 0.6508
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0008 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.025 0.0242
Loa Loa (eye worm) hypothetical protein 0.0022 0.0207 0.0199
Mycobacterium ulcerans beta-lactamase 0.0022 0.0207 0.6508
Brugia malayi Latrophilin receptor protein 2 0.0024 0.025 0.025
Schistosoma mansoni inositol monophosphatase 0.0027 0.0318 0.0318
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0417 1 1
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0376 0.8977 0.8977
Mycobacterium leprae Probable lipase LipE 0.0022 0.0207 0.091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0077 0.1551 0.1551
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.1934 0.6065
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0417 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0414 0.0414
Loa Loa (eye worm) T-complex protein 1 0.0015 0.0026 0.0017
Loa Loa (eye worm) glutathione reductase 0.004 0.0653 0.0645
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0318 0.0318
Mycobacterium ulcerans esterase/lipase LipP 0.0022 0.0207 0.6508
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.0039 0.0619 0.0611
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0022 0.0207 0.0207
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.1934 0.6065
Brugia malayi follicle stimulating hormone receptor 0.0173 0.393 0.393
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.1934 0.6065
Entamoeba histolytica hypothetical protein 0.0031 0.0414 1
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0417 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0077 0.1551 0.1551
Echinococcus multilocularis geminin 0.022 0.5104 0.5104
Entamoeba histolytica hypothetical protein 0.0031 0.0414 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0022 0.0207 0.0649
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0022 0.0207 0.0649
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0076 0.1538 0.1531
Brugia malayi Intermediate filament tail domain containing protein 0.004 0.0637 0.0637
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0008 0.0008
Mycobacterium ulcerans lipase LipD 0.0022 0.0207 0.6508
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0417 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.2189 0.6864
Trichomonas vaginalis penicillin-binding protein, putative 0.0022 0.0207 0.6508
Loa Loa (eye worm) hypothetical protein 0.0258 0.6043 0.604
Leishmania major hypothetical protein, conserved 0.0022 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0207 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0052 0.0942 0.0942
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0015 0.0026 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0173 0.393 0.3925
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0414 0.0414
Toxoplasma gondii t-complex protein beta subunit 0.0015 0.0026 0.0392
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0015 0.0026 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0265
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0024 0.025 0.025
Trichomonas vaginalis penicillin-binding protein, putative 0.0022 0.0207 0.6508
Loa Loa (eye worm) hypothetical protein 0.0024 0.025 0.0242
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0014 0.0008 0.0265
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0102
Schistosoma mansoni hypothetical protein 0.0024 0.025 0.025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0022 0.0207 0.6508
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0417 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0022 0.0207 0.0207
Mycobacterium tuberculosis Conserved protein 0.0022 0.0207 0.0649
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.012
Echinococcus granulosus GPCR family 2 0.0024 0.025 0.025
Plasmodium falciparum glutathione reductase 0.004 0.0653 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0008 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0653 0.0653
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0653 0.0645
Echinococcus granulosus intermediate filament protein 0.004 0.0637 0.0637
Onchocerca volvulus 0.004 0.0637 0.0629
Schistosoma mansoni hypothetical protein 0.022 0.5104 0.5104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0076 0.1538 0.1538
Echinococcus multilocularis musashi 0.004 0.0637 0.0637
Onchocerca volvulus 0.0258 0.6043 0.604
Mycobacterium tuberculosis Probable lipase LipE 0.0022 0.0207 0.0649
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0207 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.1551 0.1551
Echinococcus granulosus lamin dm0 0.004 0.0637 0.0637
Echinococcus granulosus lysosomal protective protein 0.0417 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0022 0.0207 0.0649
Plasmodium falciparum thioredoxin reductase 0.004 0.0653 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0077 0.1551 0.1551
Echinococcus granulosus geminin 0.022 0.5104 0.5104
Treponema pallidum NADH oxidase 0.0014 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.1551 0.1551
Mycobacterium tuberculosis Conserved protein 0.0022 0.0207 0.0649
Schistosoma mansoni hypothetical protein 0.022 0.5104 0.5104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.025 0.025
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.2189 0.6864
Loa Loa (eye worm) hypothetical protein 0.0022 0.0207 0.0199
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.025 0.025
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0653 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.1551 0.1551
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0318 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0015 0.0026 0.0026
Leishmania major T-complex protein 1, beta subunit, putative 0.0015 0.0026 0.0026
Loa Loa (eye worm) intermediate filament protein 0.004 0.0637 0.0629
Echinococcus multilocularis lamin 0.004 0.0637 0.0637
Schistosoma mansoni intermediate filament proteins 0.004 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0022 0.0207 0.0199
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.025 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0207 0.0207
Giardia lamblia TCP-1 chaperonin subunit beta 0.0015 0.0026 1
Brugia malayi Inositol-1 0.0027 0.0318 0.0318
Echinococcus multilocularis GPCR, family 2 0.0024 0.025 0.025
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.1934 0.6065

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.939 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.902 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.895 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.891 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.839 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.825 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.68 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.677 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.587 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.