Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0271 | 0.1057 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0053 | 0.0447 | 0.1662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.013 | 0.133 | 0.5156 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0271 | 0.1057 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0081 | 0.0775 | 0.2722 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.0447 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0296 | 0.0983 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0032 | 0.0217 | 0.0193 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0016 | 0.0029 | 0.0011 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.0447 | 0.1531 |
Onchocerca volvulus | 0.0053 | 0.0447 | 0.7697 | |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0032 | 0.0217 | 0.0698 |
Brugia malayi | brahma associated protein 60 kDa | 0.0032 | 0.0217 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0296 | 0.0983 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.0081 | 0.0775 | 0.2722 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0258 | 0.2783 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0217 | 0.0698 |
Onchocerca volvulus | 0.0032 | 0.0217 | 0.3508 | |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0032 | 0.0217 | 0.0475 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0029 | 0.0016 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.0447 | 0.1662 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0032 | 0.0217 | 0.0698 |
Onchocerca volvulus | 0.0064 | 0.0573 | 1 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0468 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0468 | 0.1608 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0459 | 0.1577 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0015 | 0.0024 | 0.0095 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0239 | 0.2567 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0019 | 0.0065 | 0.0255 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0081 | 0.0775 | 0.2722 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.013 | 0.133 | 0.4731 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0053 | 0.0447 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0029 | 0.0004 |
Echinococcus multilocularis | tumor protein p63 | 0.0371 | 0.4079 | 0.4064 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.0573 | 0.1989 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.013 | 0.133 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0135 | 0.1386 | 0.4933 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0032 | 0.0217 | 0.0475 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0081 | 0.0775 | 0.2612 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0053 | 0.0447 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0016 | 0.0029 | 0.0011 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.0447 | 0.1531 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0239 | 0.2567 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.0447 | 0.1531 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0217 | 0.0698 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.013 | 0.133 | 0.4731 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0258 | 0.2783 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0217 | 0.0799 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0015 | 0.0024 | 0.0095 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0239 | 0.2567 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.013 | 0.133 | 0.4731 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0081 | 0.0775 | 0.3021 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0015 | 0.0024 | 0.0095 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0015 | 0.0024 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0296 | 0.0983 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0032 | 0.0217 | 0.0698 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0015 | 0.0024 | 0.0095 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0032 | 0.0217 | 0.0193 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0258 | 0.2783 | 0.2766 |
Onchocerca volvulus | 0.0054 | 0.0468 | 0.8081 | |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0015 | 0.0024 | 0.0095 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0258 | 0.2783 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0371 | 0.4079 | 1 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0019 | 0.0065 | 0.0161 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0271 | 0.1057 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0039 | 0.0296 | 0.0847 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.0258 | 0.2783 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0032 | 0.0217 | 0.0698 |
Chlamydia trachomatis | SWIB complex protein | 0.0032 | 0.0217 | 0.0557 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0015 | 0.0024 | 0.0095 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0239 | 0.2567 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.0447 | 0.1531 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0081 | 0.0775 | 0.1852 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0258 | 0.2783 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0039 | 0.0296 | 0.1067 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0459 | 0.1577 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0121 | 0.1221 | 0.4338 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0015 | 0.0024 | 0.0095 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0053 | 0.0447 | 0.1662 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0016 | 0.0029 | 0.0004 |
Brugia malayi | CXXC zinc finger family protein | 0.0064 | 0.0573 | 0.1989 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0081 | 0.0775 | 0.0753 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0258 | 0.2783 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0053 | 0.0447 | 0.1662 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Toxoplasma gondii | cathepsin CPC1 | 0.013 | 0.133 | 0.4731 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0293 | 0.0974 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) | 0.0028 | 0.0163 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0447 | 0.1531 |
Echinococcus multilocularis | cpg binding protein | 0.0067 | 0.0615 | 0.0592 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.0073 | 0.0049 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0086 | 0.0826 | 0.3218 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0039 | 0.0293 | 0.0663 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0039 | 0.0293 | 0.0974 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0032 | 0.0217 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0293 | 0.0974 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0258 | 0.2783 | 0.6805 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.013 | 0.133 | 0.4731 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.0447 | 0.1662 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0258 | 0.2783 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0039 | 0.0293 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0447 | 0.1531 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0064 | 0.0573 | 0.1989 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.0447 | 0.1531 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0039 | 0.0293 | 0.0974 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0258 | 0.2783 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0032 | 0.0217 | 0.0698 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0296 | 0.0983 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0015 | 0.0024 | 0.0095 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0271 | 0.1057 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0032 | 0.0217 | 0.0698 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.007 | 0.0166 |
Loa Loa (eye worm) | brahma associated protein | 0.0032 | 0.0217 | 0.0698 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0258 | 0.2783 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0293 | 0.0974 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0032 | 0.0217 | 0.0193 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit beta | 0.0028 | 0.0163 | 0.0544 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0081 | 0.0775 | 0.2722 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.0296 | 0.1152 |
Mycobacterium leprae | conserved hypothetical protein | 0.0019 | 0.0065 | 0.0161 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.0028 | 0.0163 | 0.0502 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.013 | 0.133 | 0.4731 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0015 | 0.0024 | 0.0095 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0053 | 0.0447 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0447 | 0.1531 |
Echinococcus granulosus | cpg binding protein | 0.0067 | 0.0615 | 0.1456 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.0081 | 0.0775 | 0.2722 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0053 | 0.0447 | 0.1662 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.0217 | 0.0698 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0039 | 0.0293 | 0.0974 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0015 | 0.0024 | 0.0095 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.0073 | 0.012 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0053 | 0.0447 | 0.1662 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0293 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0296 | 0.0983 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0258 | 0.2783 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0239 | 0.2567 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0039 | 0.0293 | 0.027 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0073 | 0.0683 | 0.2386 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0028 | 0.0163 | 0.0502 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0217 | 0.0698 |
Brugia malayi | Kringle domain containing protein | 0.0039 | 0.0293 | 0.0974 |
Brugia malayi | ribonucleotide reductase 2 | 0.0081 | 0.0775 | 0.2722 |
Loa Loa (eye worm) | histone methyltransferase | 0.002 | 0.0073 | 0.0176 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.0447 | 0.1531 |
Schistosoma mansoni | cpg binding protein | 0.0067 | 0.0615 | 0.2139 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0053 | 0.0447 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0081 | 0.0775 | 0.2722 |
Schistosoma mansoni | cpg binding protein | 0.0067 | 0.0615 | 0.2139 |
Plasmodium vivax | ribonucleotide reductase small subunit, putative | 0.0028 | 0.0163 | 0.0502 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.0447 | 0.1741 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0081 | 0.0775 | 0.3021 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.0296 | 0.0983 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0258 | 0.2783 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0032 | 0.0217 | 0.0698 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.013 | 0.133 | 0.4731 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0015 | 0.0024 | 0.0095 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.0296 | 0.0983 |
Onchocerca volvulus | 0.0039 | 0.0293 | 0.4898 | |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0081 | 0.0775 | 0.2722 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0015 | 0.0024 | 0.0045 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0032 | 0.0217 | 0.0557 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0032 | 0.0217 | 0.0698 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0053 | 0.0447 | 0.1741 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.0447 | 0.1662 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0032 | 0.0217 | 0.0698 |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0293 | 0.0974 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8000 nM | Inhibitory potency against Herpes Simplex virus ribonucleotide reductase | ChEMBL. | No reference |
IC50 (binding) | = 11000 nM | Inhibitory potency against Varicella zoster virus ribonucleotide reductase | ChEMBL. | No reference |
IC50 (binding) | = 15 uM | Inhibitory activity was determined against HSV-1 Ribonucleoside diphosphate reductase | ChEMBL. | 2153825 |
IC50 (binding) | = 60 uM | Inhibitory activity against HSV-1 Ribonucleoside diphosphate reductase was determined | ChEMBL. | 2153825 |
Relative inhibition (binding) | = 400 % | Relative inhibition of Ribonucleoside diphosphate reductase by the compound compared to HSV-R2-(329-337) | ChEMBL. | 2153825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.