Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | peptidase, M28 family protein | 0.037 | 0.0287 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.037 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.0287 | 0.0287 |
Onchocerca volvulus | Fxna peptidase homolog | 0.037 | 0.0287 | 0.0287 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.037 | 0.0287 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.037 | 0.0287 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2325 | 1 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.0287 | 0.0287 |
Brugia malayi | leucyl aminopeptidase | 0.037 | 0.0287 | 0.0287 |
Leishmania major | hypothetical protein, conserved | 0.037 | 0.0287 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.037 | 0.0287 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.037 | 0.0287 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2325 | 1 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2325 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.0287 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.037 | 0.0287 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.037 | 0.0287 | 0.0287 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.037 | 0.0287 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2325 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.0287 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.0287 | 0.0287 |
Toxoplasma gondii | hypothetical protein | 0.037 | 0.0287 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.037 | 0.0287 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.037 | 0.0287 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.037 | 0.0287 | 0.5 |
Brugia malayi | nicalin | 0.037 | 0.0287 | 0.0287 |
Onchocerca volvulus | 0.037 | 0.0287 | 0.0287 | |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.0287 | 0.0287 |
Brugia malayi | FXNA | 0.037 | 0.0287 | 0.0287 |
Onchocerca volvulus | Fxna peptidase homolog | 0.037 | 0.0287 | 0.0287 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.0287 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 nM | Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluorescence polarization assay | ChEMBL. | 24900346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.