Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.8661 | 0.8661 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0356 | 1 | 1 |
Onchocerca volvulus | 0.0312 | 0.8661 | 0.8661 | |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0057 | 0.0763 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0057 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0057 | 0.0763 | 0.0763 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0057 | 0.0763 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0763 | 0.0763 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0057 | 0.0763 | 0.0763 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0057 | 0.0763 | 0.0763 |
Onchocerca volvulus | 0.0057 | 0.0763 | 0.0763 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0763 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0057 | 0.0763 | 0.0763 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0057 | 0.0763 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0356 | 1 | 1 |
Brugia malayi | nicalin | 0.0057 | 0.0763 | 0.0763 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0057 | 0.0763 | 0.0763 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0057 | 0.0763 | 0.0763 |
Mycobacterium tuberculosis | Conserved protein | 0.0057 | 0.0763 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0057 | 0.0763 | 0.0763 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0763 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0763 | 0.5 |
Schistosoma mansoni | nicalin (M28 family) | 0.0057 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0057 | 0.0763 | 0.0763 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0356 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.0763 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0057 | 0.0763 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0057 | 0.0763 | 0.0763 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0057 | 0.0763 | 0.0763 |
Mycobacterium ulcerans | hypothetical protein | 0.0057 | 0.0763 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0057 | 0.0763 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0763 | 0.0763 |
Brugia malayi | FXNA | 0.0057 | 0.0763 | 0.0763 |
Brugia malayi | leucyl aminopeptidase | 0.0057 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0763 | 0.0763 |
Brugia malayi | hypothetical protein | 0.0312 | 0.8661 | 0.8661 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0763 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0057 | 0.0763 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0057 | 0.0763 | 0.0763 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0057 | 0.0763 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0763 | 0.0763 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0057 | 0.0763 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluorescence polarization assay | ChEMBL. | 24900346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.