Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | P2X receptor subunit | 0.0957 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0957 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0018 | 0.0105 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0206 | 1 |
Echinococcus multilocularis | ras-related protein rab-5 | 0.0028 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0085 | 0.0814 | 0.1069 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0206 | 0.0206 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0331 | 0.3399 | 0.3399 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.1192 | 0.1192 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0206 | 0.0153 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0652 | 0.6786 | 0.6786 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0647 | 0.674 | 0.674 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0028 | 0.0206 | 0.5 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0028 | 0.0206 | 1 |
Brugia malayi | RAB, member of RAS oncogene family-like 5 | 0.0028 | 0.0206 | 0.0252 |
Schistosoma mansoni | P2X receptor subunit | 0.0957 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0206 | 0.0153 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0028 | 0.0206 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0028 | 0.0206 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0206 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0206 | 0.0153 |
Onchocerca volvulus | 0.0028 | 0.0206 | 0.5 | |
Schistosoma mansoni | P2X receptor subunit | 0.0957 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0085 | 0.0814 | 0.1159 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0647 | 0.674 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0957 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0121 | 0.1192 | 0.1192 |
Brugia malayi | Protein kinase domain containing protein | 0.0647 | 0.674 | 1 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0028 | 0.0206 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0957 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0206 | 1 |
Echinococcus multilocularis | GTP binding protein Parf | 0.0028 | 0.0206 | 0.0206 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0331 | 0.3399 | 0.3399 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0206 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0957 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0206 | 0.0252 |
Echinococcus granulosus | GTP binding protein Parf | 0.0028 | 0.0206 | 0.0206 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0028 | 0.0206 | 1 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0028 | 0.0206 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0206 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0085 | 0.0814 | 0.1069 |
Brugia malayi | Ras-related protein ypt4 | 0.0028 | 0.0206 | 0.0252 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0331 | 0.3399 | 0.3399 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.1192 | 0.1192 |
Echinococcus granulosus | geminin | 0.0121 | 0.1192 | 0.1192 |
Echinococcus granulosus | rab protein 3 | 0.0028 | 0.0206 | 0.0206 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0105 | 0.01 |
Echinococcus multilocularis | rab protein 3 | 0.0028 | 0.0206 | 0.0206 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0206 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0206 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0957 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0957 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0331 | 0.3399 | 0.3399 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0206 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.