Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis familiaris | Transient receptor potential M8 protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1108 aa | 25.5 % |
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1114 aa | 24.9 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential M8 protein | 1104 aa | 1075 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0034 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | fatty acid synthase | 0.0052 | 0.4277 | 0.4318 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0053 | 0.4361 | 0.581 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0053 | 0.4361 | 0.4361 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0021 | 0.061 | 0.0817 |
Mycobacterium ulcerans | polyketide synthase | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.0044 | 0.3311 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0035 | 0.2228 | 0.2981 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0043 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | thioesterase TesA | 0.0044 | 0.3311 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0053 | 0.4361 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0042 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0056 | 0.4752 | 0.6357 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0095 | 0.9416 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0051 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0051 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0049 | 0.3948 | 0.528 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0056 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0042 | 0.3131 | 0.4188 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.003 | 0.1644 | 0.2199 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0044 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0018 | 0.0229 | 0.0306 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0042 | 0.3131 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0079 | 0.7476 | 1 |
Onchocerca volvulus | 0.0092 | 0.9025 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0035 | 0.2228 | 0.2941 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0017 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0079 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0044 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0079 | 0.7476 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0056 | 0.4752 | 0.6337 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0079 | 0.7476 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0056 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0053 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0056 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0049 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0035 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.4752 | 0.6357 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0038 | 0.2547 | 0.3708 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0017 | 0.0042 | 0.0056 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.3948 | 0.3948 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0038 | 0.2588 | 0.3461 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0056 | 0.4752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.8643 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0053 | 0.4361 | 0.5834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.065 uM | Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured every 5 mins by FLIPR assay | ChEMBL. | 22421018 |
Inhibition (functional) | Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ release at 10 uM measured for 5 mins by FLIPR assay | ChEMBL. | 22421018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.