Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0097 | 0.1235 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0097 | 0.1235 | 0.1235 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0097 | 0.1235 | 0.1235 |
Brugia malayi | RNA, U transporter 1 | 0.0095 | 0.1214 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1235 | 0.1235 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0152 | 0.1232 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0097 | 0.1235 | 0.1235 |
Brugia malayi | leucyl aminopeptidase | 0.0097 | 0.1235 | 0.1235 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0097 | 0.1235 | 0.1235 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0607 | 1 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0607 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0097 | 0.1235 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0097 | 0.1235 | 0.1235 |
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0.0043 | 0.035 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.035 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0097 | 0.1235 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0097 | 0.1235 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0034 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1235 | 0.1235 |
Brugia malayi | Importin beta-1 subunit | 0.0034 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.027 | 0.4204 | 0.4204 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0607 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0097 | 0.1235 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0034 | 0.0152 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0097 | 0.1235 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0097 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0043 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0097 | 0.1235 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0097 | 0.1235 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0358 | 0.5727 | 0.5727 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1235 | 0.1235 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0607 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0358 | 0.5727 | 0.5727 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0358 | 0.5727 | 0.5727 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.035 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0097 | 0.1235 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0034 | 0.0152 | 0.1232 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.035 |
Echinococcus granulosus | importin subunit beta 1 | 0.0034 | 0.0152 | 0.0152 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0097 | 0.1235 | 0.5 |
Brugia malayi | nicalin | 0.0097 | 0.1235 | 0.1235 |
Plasmodium vivax | importin-beta 2, putative | 0.0034 | 0.0152 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0097 | 0.1235 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0097 | 0.1235 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0358 | 0.5727 | 0.5727 |
Mycobacterium ulcerans | hypothetical protein | 0.0097 | 0.1235 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0152 | 0.1232 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0097 | 0.1235 | 0.1235 |
Brugia malayi | FXNA | 0.0097 | 0.1235 | 0.1235 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0043 | 0.035 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0097 | 0.1235 | 0.1235 |
Schistosoma mansoni | nicalin (M28 family) | 0.0097 | 0.1235 | 0.1235 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0097 | 0.1235 | 0.1235 |
Brugia malayi | follicle stimulating hormone receptor | 0.027 | 0.4204 | 0.4204 |
Schistosoma mansoni | importin beta-1 | 0.0034 | 0.0152 | 0.0152 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0097 | 0.1235 | 1 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0097 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1235 | 0.1235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.464 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.895 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.873 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.638 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.632 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.578 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.576 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.54 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.488 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.447 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.309 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.