Detailed information for compound 1649360

Basic information

Technical information
  • TDR Targets ID: 1649360
  • Name: 1-(2,4-dimethoxyphenyl)diselanyl-2,4-dimethox ybenzene
  • MW: 432.232 | Formula: C16H18O4Se2
  • H donors: 0 H acceptors: 0 LogP: 3.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1[Se][Se]c1ccc(cc1OC)OC
  • InChi: 1S/C16H18O4Se2/c1-17-11-5-7-15(13(9-11)19-3)21-22-16-8-6-12(18-2)10-14(16)20-4/h5-10H,1-4H3
  • InChiKey: WEEVNOXMHRQLEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,4-dimethoxyphenyl)diselanyl-2,4-dimethoxy-benzene
  • NSC632606
  • NCI60_010714
  • Bis(2,4-dimethoxyphenyl)diselenide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Putative transporter 0.0014 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus granulosus General substrate transporter 0.0088 0.193 0.851
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Mycobacterium ulcerans sugar transporter 0.0014 0.0217 0.5239
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0597 0.2583
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3734 0.5643
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0612 0.0925
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0016 0.0468
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0217 0.0327
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0414 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Onchocerca volvulus 0.0014 0.0217 0.5
Schistosoma mansoni protein kinase 0.0031 0.0611 0.2648
Toxoplasma gondii protein kinase, putative 0.0288 0.6617 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0597 0.2583
Trypanosoma brucei glucose transporter 2A 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei sugar transporter, putative 0.0014 0.0217 0.303
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0217 0.0201
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Toxoplasma gondii sugar transporter ST3 0.0014 0.0217 0.0327
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0597 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0016 0.0377
Plasmodium falciparum hexose transporter 0.0102 0.2266 0.2253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3734 0.3724
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0621 0.274
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0597 0.2634
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0031 0.0611 0.2648
Onchocerca volvulus 0.0014 0.0217 0.5
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0612 0.0925
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0134 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0715 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.5
Onchocerca volvulus 0.0014 0.0217 0.5
Trypanosoma brucei glucose transporter 1E 0.0032 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 0.5587
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0414 0.6932
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0612 0.0597
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0414 0.1826
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0016 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni glucose transport protein 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis General substrate transporter 0.0088 0.193 0.851
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0621 0.868
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0715 0.0701
Giardia lamblia Sugar-proton symporter 0.0014 0.0217 0.346
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.5
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Leishmania major hypothetical protein, conserved 0.0014 0.0217 0.303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0217 0.5239
Plasmodium vivax hexose transporter 0.0102 0.2266 0.2253
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0612 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major glucose transporter, lmgt2 0.0032 0.0621 0.868
Onchocerca volvulus 0.0014 0.0217 0.5
Entamoeba histolytica protein kinase, putative 0.0031 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0217 0.0894
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3734 0.3724
Loa Loa (eye worm) sugar transporter 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0894
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0894
Toxoplasma gondii sugar transporter ST2 0.0014 0.0217 0.0327
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Toxoplasma gondii sugar transporter ST1 0.0014 0.0217 0.0327
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0715 0.1081
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0611 0.2648
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0611 0.2648
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0025 0.0463 0.1987
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0611 0.2648
Schistosoma mansoni glucose transporter 0.0014 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0612 0.0597
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.5
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0611 0.2648
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0612 0.0597
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0414 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0217 0.6499
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Onchocerca volvulus 0.0014 0.0217 0.5
Leishmania major glucose transporter, lmgt1 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0031 0.0611 0.2648
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2266 1
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2266 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0217 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Plasmodium falciparum protein kinase 7 0.0288 0.6617 0.6612
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trypanosoma cruzi hexose transporter 0.0032 0.0621 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0611 0.2648
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0566 0.2448
Loa Loa (eye worm) sugar transporter 0.0102 0.2266 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0175 0.0709
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Schistosoma mansoni glucose transport protein 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Leishmania major protein kinase, putative 0.0031 0.0611 0.855
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0031 0.0611 0.2648
Schistosoma mansoni hypothetical protein 0.0102 0.2266 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0597 0.2583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0217 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0217 0.303
Entamoeba histolytica hypothetical protein 0.0023 0.0414 0.6679
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Brugia malayi Sugar transporter family protein 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0611 0.855
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0217 0.303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0566 0.2448
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0016 0.0024
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0217 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0715 0.0701
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0217 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0217 0.5239
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Schistosoma mansoni glucose transport protein 0.0102 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.2583
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0612 0.0597
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0612 0.0597
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0597 1
Brugia malayi Cam kinase protein 1 0.0031 0.0611 0.2648
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0414 0.6849
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0597 0.2583
Entamoeba histolytica protein kinase, putative 0.0031 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.2583
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0715 1
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0414 0.0625
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0016 0.0024
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0414 0.1769
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0134 0.2978
Plasmodium vivax sugar transporter, putative 0.0014 0.0217 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0023 0.0414 0.1769
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0217 0.6499
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0414 0.0399
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0621 0.274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0286 0.3994
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0611 0.2699
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2266 0.3424
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0414 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0621 0.274
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0217 0.303
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0348 0.1536
Onchocerca volvulus 0.0014 0.0217 0.5
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0016 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major glucose transporter, lmgt3 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0333 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0612 0.0597
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0597 0.2583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0612 0.0597
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0612 0.0597
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Giardia lamblia Hexose transporter 0.0014 0.0217 0.346
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0597 0.9752
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0597 0.2583
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0612 0.0925
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0134 0.3243

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.758 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.7 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.629 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.619 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.615 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.544 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.534 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.343 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.105 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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