Detailed information for compound 1650024

Basic information

Technical information
  • TDR Targets ID: 1650024
  • Name: 2,4-diaminobutanoic acid hydrochloride
  • MW: 154.595 | Formula: C4H11ClN2O2
  • H donors: 3 H acceptors: 2 LogP: -3.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(C(=O)O)CCN.Cl
  • InChi: 1S/C4H10N2O2.ClH/c5-2-1-3(6)4(7)8;/h3H,1-2,5-6H2,(H,7,8);1H
  • InChiKey: BFPDKDOFOZVSLY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,4-diaminobutyric acid hydrochloride
  • DL-2,4-Diaminobutyric acid dihydrochloride
  • D3758_SIGMA

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0468 0.1616
Loa Loa (eye worm) hypothetical protein 0.0053 0.1003 0.2612
Schistosoma mansoni protein kinase 0.0032 0.0494 0.1725
Trypanosoma brucei glucose transporter 1E 0.0032 0.0493 0.4778
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0468 0.1057
Trypanosoma brucei glucose transporter 2A 0.0032 0.0493 0.4778
Loa Loa (eye worm) sugar transporter 0.0102 0.2158 0.5748
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0493 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Leishmania major glucose transporter, lmgt2 0.0032 0.0493 0.4778
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0493 0.1973
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.025 0.1943
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.025 0.1943
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0588 0.0509
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.8713
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0495 0.0415
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0493 0.4778
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.094 0.2441
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.025 0.0802
Trichomonas vaginalis CMGC family protein kinase 0.005 0.094 0.4129
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.025 0.0802
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.094 0.4129
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0495 0.0415
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0468 0.1855
Entamoeba histolytica protein kinase, putative 0.0032 0.0494 0.3541
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Toxoplasma gondii protein kinase, putative 0.0288 0.6575 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.094 0.2441
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.025 0.1943
Giardia lamblia Kinase, CMGC GSK 0.005 0.094 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Loa Loa (eye worm) hypothetical protein 0.0032 0.0494 0.123
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0495 0.0415
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0283 0.0307
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0493 0.4778
Echinococcus multilocularis General substrate transporter 0.0087 0.1819 0.8364
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.3723 1
Leishmania major glucose transporter, lmgt1 0.0032 0.0493 0.4778
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0974 0.4295
Leishmania major protein kinase, putative 0.0032 0.0494 0.4796
Entamoeba histolytica protein kinase domain containing protein 0.005 0.094 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.3723 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0495 0.0415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0974 0.3742
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0468 0.4493
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.025 0.0802
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.094 0.0864
Echinococcus granulosus General substrate transporter 0.0087 0.1819 0.8364
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0084 0.0114
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0468 0.1855
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0495 0.0633
Brugia malayi Sugar transporter family protein 0.0102 0.2158 0.5699
Schistosoma mansoni hypothetical protein 0.0102 0.2158 0.8713
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.094 0.0864
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.8713
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Entamoeba histolytica protein kinase, putative 0.0032 0.0494 0.3541
Schistosoma mansoni protein kinase 0.0032 0.0494 0.1725
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0153 0.0815
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.2464 0.6541
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.025 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0494 0.198
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0493 0.1973
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0283 1
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.8713
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0974 0.4295
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0084 0.2954
Toxoplasma gondii exonuclease III APE 0.0021 0.025 0.0256
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0494 0.123
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.1003 0.4433
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.1003 0.2527
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0588 0.5894
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0468 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 1 1
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0438 0.1707
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0974 0.2534
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0588 0.5894
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2158 1
Echinococcus granulosus GPCR family 2 0.0053 0.1003 0.4433
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0493 0.4778
Brugia malayi Cam kinase protein 1 0.0032 0.0494 0.1129
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0468 0.1057
Schistosoma mansoni hypothetical protein 0.0053 0.1003 0.3863
Entamoeba histolytica protein kinase, putative 0.005 0.094 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0495 0.0415
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0495 0.0415
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.094 0.1319
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Onchocerca volvulus 0.005 0.094 1
Echinococcus granulosus protein kinase shaggy 0.005 0.094 0.4129
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0283 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.005 0.094 0.4129
Entamoeba histolytica hypothetical protein 0.0023 0.0283 0.0477
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0202 0.71
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Entamoeba histolytica protein kinase domain containing protein 0.005 0.094 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0495 0.0633
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.025 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2158 0.3196
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0468 0.1855
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0283 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0283 0.3046
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0084 0.2954
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0494 0.4796
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0283 0.2328
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0283 0.2328
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0974 0.4295
Schistosoma mansoni hypothetical protein 0.0053 0.1003 0.3863
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0283 0.0548
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0084 0.2954
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0588 0.5894
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3656 0.3602
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0495 0.0415
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.1003 0.4433
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Brugia malayi intracellular kinase 0.005 0.094 0.2353
Schistosoma mansoni protein kinase 0.0032 0.0494 0.1725
Trypanosoma cruzi hexose transporter 0.0032 0.0493 0.4778
Loa Loa (eye worm) hypothetical protein 0.0023 0.0283 0.0656
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.1003 0.4433
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0283 0.2328
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Giardia lamblia Kinase, CMGC GSK 0.005 0.094 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Schistosoma mansoni hypothetical protein 0.0053 0.1003 0.3863
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0974 0.2448
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0202 0.71
Plasmodium falciparum hexose transporter 0.0102 0.2158 0.2092
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0468 0.3164
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.094 0.3597
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0588 0.0509
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0468 0.1616
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.025 0.1943
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0493 0.4778
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.3723 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0494 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0493 0.1973
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0494 0.198
Schistosoma mansoni hypothetical protein 0.0053 0.1003 0.3863
Schistosoma mansoni ap endonuclease 0.0021 0.025 0.0699
Loa Loa (eye worm) hypothetical protein 0.0025 0.0333 0.0791
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0588 0.5894
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0283 0.0961
Brugia malayi Latrophilin receptor protein 2 0.0053 0.1003 0.2527
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.025 0.0802
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0283 0.2328
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.025 0.1943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0974 0.3742
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0217 0.0641
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0494 0.1129
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0283 0.0961
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0493 0.4778
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2158 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0974 0.4295
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.025 0.0457
Plasmodium falciparum protein kinase 7 0.0288 0.6575 0.6546
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3656 0.5503
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0493 0.4778
Mycobacterium ulcerans sugar transporter 0.0014 0.0084 0.2954
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.025 1
Schistosoma mansoni hypothetical protein 0.0115 0.2464 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.094 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0495 0.0415
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0494 0.123
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0283 0.0837
Leishmania major glucose transporter, lmgt3 0.0032 0.0493 0.4778
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0283 0.0961
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0495 0.0415
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0494 0.198
Trypanosoma brucei protein kinase, putative 0.005 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.2464 0.658
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3656 0.3602
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0438 0.1707
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0588 0.5894
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0283 0.0837
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0588 0.0778
Plasmodium vivax hexose transporter 0.0102 0.2158 0.2092
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0493 0.1973
Loa Loa (eye worm) sugar transporter 0.0014 0.0084 0.0114
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.025 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0974 0.3742
Loa Loa (eye worm) hypothetical protein 0.0031 0.0468 0.1159
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.094 0.4129
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0493 0.1973
Echinococcus multilocularis protein kinase shaggy 0.005 0.094 0.4129
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.025 0.0168
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.094 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.025 0.8836
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.1003 0.4433
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.1003 0.2612
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0493 0.4778
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.4778
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0493 0.1973
Schistosoma mansoni ap endonuclease 0.0021 0.025 0.0699
Loa Loa (eye worm) hypothetical protein 0.0031 0.0468 0.1159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Echinococcus multilocularis GPCR, family 2 0.0053 0.1003 0.4433
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0168 0.3723 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.025 0.0566
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0495 0.0633

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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