Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0018 | 0.0267 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0189 | 0.0197 |
Loa Loa (eye worm) | transmembrane cell adhesion receptor mua-3 | 0.0019 | 0.0318 | 0.0331 |
Onchocerca volvulus | 0.0024 | 0.0531 | 0.0413 | |
Brugia malayi | notch-like transmembrane receptor | 0.0248 | 0.9604 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0267 | 0.0278 |
Brugia malayi | EGF-like domain containing protein | 0.0024 | 0.0531 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.9604 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0026 | 0.0585 | 0.0609 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0123 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0267 | 0.0278 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0258 | 1 | 1 |
Echinococcus granulosus | notch | 0.0031 | 0.0798 | 0.0684 |
Schistosoma mansoni | notch | 0.0104 | 0.3771 | 1 |
Echinococcus multilocularis | notch | 0.0031 | 0.0798 | 0.0684 |
Loa Loa (eye worm) | Notch2 | 0.0162 | 0.6112 | 0.6365 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0123 | 0.0128 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0026 | 0.0585 | 0.0609 |
Brugia malayi | EGF-like domain containing protein | 0.0136 | 0.507 | 0.5279 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0189 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0123 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0531 | 0.0553 |
Toxoplasma gondii | microneme protein MIC12 | 0.0019 | 0.0318 | 0.5983 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0585 | 0.0609 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0189 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0585 | 0.0609 |
Onchocerca volvulus | 0.0024 | 0.0531 | 0.0413 | |
Toxoplasma gondii | notch (dsl) domain-containing protein | 0.0024 | 0.0531 | 1 |
Schistosoma mansoni | notch | 0.0031 | 0.0798 | 0.1852 |
Loa Loa (eye worm) | notch protein | 0.0026 | 0.0585 | 0.0609 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0016 | 0.0189 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0506 | 0.0527 |
Toxoplasma gondii | sushi domain (scr repeat) domain-containing protein | 0.0024 | 0.0531 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0024 | 0.0531 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0123 | 0.0128 |
Onchocerca volvulus | 0.0018 | 0.0267 | 0.0146 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0267 | 0.0278 |
Toxoplasma gondii | sushi domain (scr repeat) domain-containing protein | 0.0024 | 0.0531 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0531 | 0.1119 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0258 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0016 | 0.0189 | 0.0067 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0042 | 0.1261 | 0.1152 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.235 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.